1,721,008 research outputs found
Libri incompiuti e testi senza confini: contraddizioni e paradossi della produzione testuale antica alla luce delle testimonianze papiracee
No full text
Le avventure di Eracle in un papiro tolemaico: per una riedizione di P.Lond.Lit. 190
No full textNew edition and commentary of P. Lond Lit. 190, an early 3rd century
B.C. tattered bookroll from a mummy cartonnage found in Medinet
Gurob by W.M. Flinders Petrie during the 1890 season of his excavations
in the Fayyum. On the few surviving fragments it is possible to read mentions
to some of Herakles’ adventures, and especially an account of the
fight between him and Hippocoon, who exiled from Sparta his brother
Tyndareos and took the power on the city for a short time. This text was
probably part of a longer mythographic work written around the 4th century
B.C., as pointed out by its diction
Age-related modifications in the regulation of the hypothalamic- pituitary-thyroid axis
No full textWe studied the hypothalamic-pituitary-thyroid function in two groups of healthy elderly subjects: group A (n = 23, age range 65-80 years), and group B (n = 11, age range 81-92 years), and in 32 controls, aged 20-60. A TRH test for TSH and prolactin was performed in all subjects, while the TSH circadian modulation was evaluated in elderly subjects only. Group B showed significantly lower fT3 and TSH, and higher fT4 levels with respect to controls (fT3: 4.4 +/- 0.2 vs. 5.2 +/- 0.2 pmol/l, p < 0.05; fT4: 13.1 +/- 0.9 vs. 11.4 +/- 0.4 pmol/l, p < 0.05; TSH: 1.07 +/- 0.21 vs. 1.46 +/- 0.13 mIU/l, p < 0.05). Morning TSH showed an inverse correlation with age (r = -0.42; p < 0.02) among the 34 elderly subjects, but not among controls. Evidence for TSH circadian modulation was found only in group A (nighttime TSH: 1.60 +/- 0.17, vs. daytime: 1.25 +/- 0.13 mIU/l, p < 0.001). The TRH-stimulated TSH peak was reduced among all elderly subjects with respect to controls (A: 6.26 +/- 0.64 mIU/l, p = 0.01; B: 5.02 +/- 0.58 mIU/l, p < 0.01). The maximal PRL response was also blunted (A: 25.7 +/- 2.6 micrograms/l, B: 27.7 +/- 5.2 micrograms/l, p < 0.0005). In conclusion, a resetting of the pituitary threshold of the TSH feedback suppression, along with complex alterations in peripheral thyroid hormone levels, may progressively develop in older people, becoming apparent only with extreme senescence. Moreover, the TSH nocturnal surge may be lost with increasing age, thus providing evidence also for hypothalamic dysfunction
- …
