1,053 research outputs found
Michael Rodriguez interviews author Paul Clemens
No full textAuthor Paul Clemens talks about his book "Made in Detroit," the genre of memoir, and writing about race. Clemens is interviewed by Michigan State University Librarian Michael Rodriguez for the MSU Libraries' Michigan Writers Series. Held in the MSU Main Library
Author Paul Clemens reads from his book "Made in Detroit" at the Michigan Writers Series
No full textAuthor Paul Clemens reads from his book "Made in Detroit" and answers questions from the audience. The event is convened by Peter Berg, head of the Michigan State University Libraries' Special Collections. Part of the MSU Libraries' Michigan Writers Series. Held in the MSU Main Library
Influence of a novel, versatile bifunctional chelator on theranostic properties of a minigastrin analogue.
Get PDFBACKGROUND: 6-[Bis(carboxymethyl)amino]-1,4-bis(carboxymethyl)-6-methyl-1,4-diazepane (AAZTA ) is a promising chelator with potential advantages over 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) for radiopharmaceutical applications. Its mesocyclic structure enables fast radiolabelling under mild conditions with trivalent metals including not only (68)Ga for positron emission tomography (PET) but also (177)Lu and (111)In for single-photon emission computed tomography (SPECT) and radionuclide therapy. Here, we describe the evaluation of a bifunctional AAZTA derivative conjugated to a model minigastrin derivative as a potential theranostic agent. METHODS: An AAZTA derivative with an aliphatic C9 chain as linker was coupled to a minigastrin, namely [AAZTA(0), D-Glu(1), desGlu(2-6)]-minigastrin (AAZTA-MG), and labelled with (68)Ga, (177)Lu and (111)In. The characterisation in vitro included stability studies in different media and determination of logD (octanol/PBS). Affinity determination (IC50) and cell uptake studies were performed in A431-CCK2R cells expressing the human CCK2 receptor. μPET/CT and ex vivo biodistribution studies were performed in CCK2 tumour xenograft-bearing nude mice and normal mice. RESULTS: AAZTA-MG showed high radiochemical yields for (68)Ga (>95 %), (177)Lu (>98 %) and (111)In (>98 %). The logD value of -3.7 for both [(68)Ga]- and [(177)Lu]-AAZTA-MG indicates a highly hydrophilic character. Stability tests showed overall high stability in solution with some degradation in human plasma for [(68)Ga]- and transchelation towards DTPA for and [(177)Lu]-AAZTA-MG. An IC50 value of 10.0 nM was determined, which indicates a high affinity for the CCK2 receptor. Specific cell uptake after 60 min was >7.5 % for [(68)Ga]-AAZTA-MG and >9.5 % for [(177)Lu]-AAZTA-MG, comparable to other DOTA-MG-analogues. μPET/CT studies in CCK2 receptor tumour xenografted mice not only revealed high selective accumulation in A431-CCK2R positive tumours of (68)Ga-labelled AAZTA-MG (1.5 % ID/g in 1 h post injection) but also higher blood levels as corresponding DOTA-analogues. The (111)In-labelled peptide had a tumour uptake of 1.7 % ID/g. Biodistribution in normal mice with the [(177)Lu]-AAZTA-MG showed a considerable uptake in intestine (7.3 % ID/g) and liver (1.5 % ID/g). CONCLUSION: Overall, AAZTA showed interesting properties as bifunctional chelator for peptides providing mild radiolabelling conditions for both (68)Ga and trivalent metals having advantages over the currently used chelator DOTA. Studies are ongoing to further investigate in vivo targeting properties and stability issues and the influence of spacer length on biodistribution of AAZTA
Clemens Setz — an Author of Popular Literature?
No full textThis essay show the references to the so-called Popliteratur in the work of the Austrian writer Clemens Setz. Although Setz does not fit into the assumed periodization of this movement, his texts seem to have an aesthetic of pop-literature that corresponds to both the early and later approaches of the trend. The creative handling of archives of folk culture, experimental writing and the media networks have a pop-literature effect. Many texts are reminiscent of language-critical, experimental cut-up texts by the Beat Generation authors. The thematic repertoire also shows characteristic pop literary writing: There is no processing of social, political problems and the Nazi past, but, for example, the processing of generational conflicts, the problems of growing up and sexuality. The media staging of the author intended by the publisher also shows well-recognized mechanisms of pop culture
Native language identification using a meta-classifier ensemble
No full textauthor: Clemens KolbMasterarbeit University of Innsbruck 202
Native language identification using a meta-classifier ensemble
No full textauthor: Clemens KolbMasterarbeit University of Innsbruck 202
Recommended from our members
Samuel L. Clemens, Journalist
Get PDFThe purposes of this thesis are two-fold-: 1) in light of the information which is now available, to record accurately the events of the long newspaper career of Samuel L. Clemens; and, 2) to attempt to assess the influence of his journalistic experiences on him as a man, as an observer of humanity, as a reporter fulfilling his assignments, as a developing artist, and as a future author of books
Landscape Architecture at TU Delft 1973-2011: Ter gelegenheid afscheid Prof. Dr. Clemens Steenbergen
No full textHet is haast onmogelijk om de werkzame jaren van Prof. Dr. Clemens Steenbergen hier op de TU Delft in het kort samen te vatten. Dit is een persoonlijk boek van collega's, medewerkers en studenten ter gelegenheid van zijn afscheid op 15. December 2011.UrbanismArchitectur
- …
