43,849 research outputs found
Seminário sobre aquacultura 14 a 16 de dezembro de 1983
No full textA necessidade de desenvolver a aquacultura em Portugal obriga à escolha das espécies mais indicadas para tal finalidade. A propósito o autor chama a atenção para as graves consequências que podem advir das introduções e/ou transferências de animais aquáticos, quer para as espécies locais e meio ambiente, como para a para a saúde pública.Concerning the need to choose the most convenient species to cultivate in order to implement aquaculture in Portugal, the author draws the attention to the deleterious consequences of introductions and transfers of aquatic animals.Caixa Geral de Depósito
Redox-Responsive Nanocapsules for the Spatiotemporal Release of Miltefosine in Lysosome: Protection against Leishmania
No full textLeishmaniasis, a vector-borne disease, is caused by intracellular parasite Leishmania donovani. Unlike most intracellular pathogens, Leishmania donovani are lodged in parasitophorous vacuoles and replicate within the phagolysosomes in macrophages. Effective vaccines against this disease are still under development, while the efficacy of the available drugs is being questioned owing to the toxicity for nonspecific distribution in human physiology and the reported drug-resistance developed by Leishmania donovani. Thus, a stimuli-responsive nanocarrier that allows specific localization and release of the drug in the lysosome has been highly sought after for addressing two crucial issues, lower drug toxicity and a higher drug efficacy. We report here a unique lysosome targeting polymeric nanocapsules, formed via inverse mini-emulsion technique, for stimuli-responsive release of the drug miltefosine in the lysosome of macrophage RAW 264.7 cell line. A benign polymeric backbone, with a disulfide bonding susceptible to an oxidative cleavage, is utilized for the organelle-specific release of miltefosine. Oxidative rupture of the disulfide bond is induced by intracellular glutathione (GSH) as an endogenous stimulus. Such a stimuli-responsive release of the drug miltefosine in the lysosome of macrophage RAW 264.7 cell line over a few hours helped in achieving an improved drug efficacy by 200 times as compared to pure miltefosine. Such a drug formulation could contribute to a new line of treatment for leishmaniasis.A. Das acknowledges SERB (India) Grants (CRG/2020/000492 and JCB/2017/000004) and DBT Grant (BT/PR22251/NNT/28/1274/2017) for supporting this research. N. Mukherjee acknowledges SERB (India) Grant PDF/2016/001437 and K. Das acknowledges the grant EMR/2015/001674 for supporting this research. Financial support from DST (DST/INSPIRE/03/2017/002477) is acknowledged by R.T. This manuscript bears CSMCRI registration no 7/2021.Pramanik, SK (corresponding author), CSIR Cent Salt & Marine Chem Res Inst, Bhavnagar 364002, Gujarat, India.
Mukherjee, N (corresponding author), CSIR Indian Inst Chem Biol, Canc Biol & Inflammatory Disorder Div, Kolkata 700032, India.
Chattopadhy, S (corresponding author), BITS Pilani, Pilani 403726, Goa, India.
Das, A (corresponding author), Indian Inst Sci Educ & Res Kolkata, Mohanpur 741246, W Bengal, India.
[email protected]; [email protected]; [email protected]
Interview with Indra Das
No full textIndra Das is most well-recognized as the author of The Devourers (2015), a novel that won the Lambda Literary Award for straddling the genres of sci-fi, speculative, and fantasy fiction alongside LGBT themes. Das’s short fiction is widely published is horror and sci-fi anthologies, as well as magazines like Tor.com, Strange Horizons, and Asimov’s Science Fiction. He spoke candidly with Alok Amatya over email about the current literary landscape, the work of writing transgressive genre fiction, and his own experiences as an upcoming global author
"PULS." - Ein Blog als Online-Magazin für Medizinstudierende der Goethe-Universität Frankfurt
No full textIm Herbst 2009 forderten Studierende im Rahmen landesweiter Proteste auch am Fachbereich Medizin/Zahnmedizin der Goethe-Universität Frankfurt mehr Transparenz und Kommunikation zu Angelegenheiten ihres Studiums. Einen innovativen Lösungsansatz, um diesen Forderungen nachzukommen, bietet eines der Web 2.0 Werkzeuge: ein auf einer Blog-Software basierendes Online-Magazin für Studierende und andere Mitglieder des Fachbereichs.
Das öffentlich zugängliche Online-Magazin "PULS." (https://newsmagazin.puls.med.uni-frankfurt.de/wp/) wird mit einer freien Blog-Software (wordpress Version 3.1.3.) realisiert und von einer Online-Redakteurin konzipiert und geschrieben. Die Beiträge entstehen nach eigenen Recherchen sowie aus Anregungen und Gesprächen mit verschiedenen Personengruppen des Fachbereichs. Die datenschutzkonforme Auswertung der Zugriffe erfolgt über eine open-source Webanalyse-Software (Piwik). Zusätzlich werden jährlich mit dem Online-Umfrage-Tool Survey Monkey die Nutzer anonym befragt.
"PULS." ist seit dem 14.02.2010 ununterbrochen online und hat seitdem 806 Beiträge (Stand: 27.11.2012) publiziert und wird von ca. 2400 Besuchern monatlich gelesen. Das Themenspektrum ist zentriert auf die Anliegen der Frankfurter Medizin- und Zahnmedizinstudierenden. Die enge Zusammenarbeit mit verschiedenen Gruppierungen des Fachbereichs – Dekanat, Studierende und Lehrende – garantiert darüber hinaus ein fachbereichs-relevantes Themenspektrum. Das Online-Magazin begleitet komplexe Projekte und Entscheidungen mit Hintergrundinformationen und kommuniziert sie verständlich. Eine jährliche Nutzer-Evaluierung zeigt eine wachsende Leserzahl und eine sehr hohe Zustimmung für das Online-Magazin, seine Inhalte und seinen Stil. Das Web 2.0-Medium "Blog" und seine web-typische Sprache entsprechen dem Medienverhalten der Zielgruppe, d.h. den Studierenden des Fachbereichs Medizin.
"PULS." hat sich als ein geeignetes und strategisches Instrument erwiesen, um größere Transparenz, mehr Kommunikation und letztendlich eine stärkere Identifikation der Studierenden mit ihrem Fachbereich voranzutreiben
Die Türkei und das andere Europa : Phantasmen der Identität im Beitrittsdiskurs /
No full textDiese Studie analysiert das dialogische Zusammenspiel zwischen den europäischen und türkischen Diskursen um den möglichen EU-Beitritt der Türkei. Die Differenzen stellen in der Perspektive postkolonialer Theorien ein ambivalentes und formatives Moment für die Bildung einer europäischen Identität dar: Die Europäer nehmen die Beitrittsverhandlungen zum Anlass, über ihr Selbstverständnis zu reflektieren, wobei diverse Ost-West-Repräsentationen kommuniziert und strukturiert werden. Die muslimischen Migranten in Europa und die Minderheiten in der Türkei fungieren dabei als interne Symptome, die die Unvollständigkeit der europäischen bzw. türkischen Identitäten sichtbar machen.Diese Studie analysiert das dialogische Zusammenspiel zwischen den europäischen und türkischen Diskursen um den möglichen EU-Beitritt der Türkei. Die Differenzen stellen in der Perspektive postkolonialer Theorien ein ambivalentes und formatives Moment für die Bildung einer europäischen Identität dar: Die Europäer nehmen die Beitrittsverhandlungen zum Anlass, über ihr Selbstverständnis zu reflektieren, wobei diverse Ost-West-Repräsentationen kommuniziert und strukturiert werden. Die muslimischen Migranten in Europa und die Minderheiten in der Türkei fungieren dabei als interne Symptome, die die Unvollständigkeit der europäischen bzw. türkischen Identitäten sichtbar machen.Bülent Küçük (Dr. phil.) ist Soziologe und arbeitet im Forschungsprojekt "Eurosphere" an der Sabancà Universität in Istanbul. Seine Forschungsschwerpunkte sind Öffentlichkeits-, Diskurs- und Postkoloniale Theorien.Online resource; title from PDF title page (publisher's Web site, viewed October 7 2015).Includes bibliographical references.JSTO
Climate and anthropogenic change in aquatic environments: A cross ecosystem perspective
No full textThe chapter, "Climate and anthropogenic change in aquatic environments: A cross ecosystem perspective" was written by the listed authors including Jessica L. Clasen (Douglas College Faculty). The Ecological Dissertations in the Aquatic Sciences (Eco-DAS) symposia bring together 35-40 recent PhD recipients for one week in alternate years. Eco-DAS VIII was held in 2008. Eco-DAS is sponsored by the Center for Microbial Oceanography: Research and Education (C-MORE), the University of Hawai`i School of Ocean and Earth Science and Technology (SOEST) and its Department of Oceanography, and the Association for the Sciences of Limnology and Oceanography (ASLO). The Proceedings of Eco-DAS VIII includes nine chapters published in open access.
In an effort to foster collaboration among researchers across diverse ecosystems, a group of early career scientists whose interests span the aquatic sciences, convened at the University of Hawai’i to participate in the 2008 Eco-DAS symposium. During a break out session of the symposium in which participants were charged with discussing how to best approach mitigation of climate and anthropogenic threats to aquatic ecosystems, participants concluded that effective mitigation will depend upon prioritizing threats across ecosystems. These priorities were documented using a thought experiment in which participants defined their ecosystem of expertise, and then ranked the highest-priority threats to them. Results revealed that marine (open ocean, deep sea, coastal oceans, and rocky intertidal) researchers ranked climate-related impacts (i.e., temperature and ocean acidification) as the highest priority threats whereas estuarine, marsh, wetland, stream, and lake/reservoir researchers ranked the direct anthropogenic impacts of land-use change and nutrient inputs (eutrophication) highest. With such a diverse group, it became apparent that working across ecosystems is limited by issues rang- ing from a lack of large-scale, long-term monitoring to provide baseline data, to broader questions of how changes in one ecosystem cascade across interconnected ecosystems. Here we summarize the discussions, offer insight into the rankings for specific ecosystems, and propose ideas of how past, current, and future research can be used to support a cross-ecosystem perspective on climate and anthropogenic change.book chapterPublished
Testing boson rare decays with , , and in the NMSSM
No full textWe study the rare decay process of boson into photon, accompanied by a
CP-even or CP-odd scalar. We present the analytical delineation of the
processes through the model-independent parametrizations of the new physics
couplings and, finally, consider the Next-to-Minimal Supersymmetric Standard
Model to mark out the parameter space where the branching fraction can have the
maximum value. As a part of the necessary phenomenological and experimental
cross-checks, we aim to fit the anomalous magnetic moment of the muon and
boson mass anomaly through the supersymmetric contributions. We also find that
the decays can serve as an excellent
complementary test to . In fact, to facilitate
future searches, we unveil a few benchmark points that additionally satisfy the
deviation of from the SM value based on the recent
measurements of ATLAS and CMS. Future proposals such as ILC, CEPC, and FCC-ee
are anticipated to operate for multiple years, focusing on center-of-mass
energy near the pole. Consequently, these projects will be capable of
conducting experiments at the Giga- ( of bosons) and Tera-
( of bosons) phases, which may probe the aforesaid rare decay
processes, thus the model as well. These unconventional yet complementary
searches offer different routes to explore the supersymmetric models with
extended Higgs sectors like NMSSM.Comment: 38 pages, 4 figures, 3 tables, version to be published in EPJ
Light dark matter in the NMSSM: upper bounds on direct detection cross sections
No full text17 pages, 3 figuresInternational audienceIn the Next-to-Minimal Supersymmetric Standard Model, a bino-like LSP can be as light as a few GeV and satisfy WMAP constraints on the dark matter relic density in the presence of a light CP-odd Higgs scalar. We study upper bounds on the direct detection cross sections for such a light LSP in the mass range 2-20 GeV in the NMSSM, respecting all constraints from B-physics and LEP. The OPAL constraints on e^+ e^- -> \chi^0_1 \chi^0_i (i > 1) play an important role and are discussed in some detail. The resulting upper bounds on the spin-independent and spin-dependent nucleon cross sections are ~ 10^{-42} cm^{-2} and ~ 4\times 10^{-40} cm^{-2}, respectively. Hence the upper bound on the spin-independent cross section is below the DAMA and CoGeNT regions, but could be compatible with the two events observed by CDMS-II
One-loop contribution to the neutrino mass matrix in the next-to-minimal supersymmetric standard model with right-handed neutrinos and tribimaximal mixing
No full text12 pages, 7 figuresInternational audienceNeutrino mass patterns and mixing have been studied in the context of next-to-minimal supersymmetric standard model (NMSSM) with three gauge singlet neutrino superfields. We consider the case with the assumption of R-parity conservation. The vacuum expectation value of the singlet scalar field of NMSSM induces the Majorana masses for the right-handed neutrinos as well as the usual -term. The contributions to the light neutrino mass matrix at the tree level as well as one-loop level are considered, consistent with the tri-bimaximal pattern of neutrino mixing. Light neutrino masses arise at the tree level through a TeV scale seesaw mechanism involving the right-handed neutrinos. Although all the three light neutrinos acquire non-zero masses at the tree-level, we show that the one-loop contributions can be comparable in size under certain conditions
The vulnerability of ecosystem trophic dynamics to anthropogenically induced environmental change: A comparative approach
No full textThe chapter, "The vulnerability of ecosystem trophic dynamics to anthropogenically induced environmental change: A comparative approach" was written by the listed authors including Jessica L. Clasen (Douglas College Faculty).
The Ecological Dissertations in the Aquatic Sciences (Eco-DAS) symposia bring together 35-40 recent PhD recipients for one week in alternate years. Eco-DAS VIII was held in 2008. Eco-DAS is sponsored by the Center for Microbial Oceanography: Research and Education (C-MORE), the University of Hawai`i School of Ocean and Earth Science and Technology (SOEST) and its Department of Oceanography, and the Association for the Sciences of Limnology and Oceanography (ASLO). The Proceedings of Eco-DAS VIII includes nine chapters published in open access.
We employed a comparative approach to review the vulnerability of the trophic interactions within aquatic systems to global threats associated with anthropogenic activities. The goal of this chapter was to identify and characterize mechanisms by which human-mediated environmental threats may modulate trophic dynamics across aquatic ecosystems. Trophic dynamics include some of the most obvious and pervasive factors influencing ecosystems and were used as a metric because of their importance and commonality across all aquatic environments. Our use of trophic dynamics proved to be insightful, illustrating that the flow of energy through aquatic food webs will be (or already has been) altered by invasive species, land-use change, nutrient loading, exposure to ultraviolet radiation, overharvesting, acidification, and increasing global temperatures. The response of trophic dynamics to these threats was often similar across oceans, estuaries, lakes, and rivers. This similarity proved to be interesting given the differences in both the level of concern expressed by scientists and the predicted variability in environment-specific responses. As the trophic interactions of an ecosystem are at the root of its function and structure, examining trophic dynamics could be an informative method for evaluating the response of aquatic environments to global threats. If future analyses validate the use of trophic dynamics as a metric, it is our hope that trophic dynamics can be used by scientists and politicians to mitigate the effects of human actions.book chapterPublished
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