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Carta del Dr. Dean A. Clark a Leloir
No full textCarta del Dr. Dean A. Clark, Director del Massachusetts General Hospital, institución asociada a la Escuela de Medicina de Harvard, en la que le propone a Leloir el puesto de Director del Biochemical Research Laboratories, para suceder en el cargo al Dr. Fritz Lipmann.original mecanografiadaFil: Clark, Dean A..2 páginas en papelLFL-PE. Correspondencia GeneralUnidad documental simplenul
Dean A. Lee
No full textDr. Dean A. Lee is Professor of Pediatrics and DiMarco Family Endowed Chair in Cell Based Therapy at Nationwide Children\u27s Hospital. He is the founding Director of the Cellular Therapy and Cancer Immunotherapy Program, a joint program between NCH and The Ohio State University James Cancer Hospital. Dr. Lee conducts clinical and translational research on natural killer (NK) cells and cancer immunotherapy. He was recruited to MD Anderson in 2006, where his laboratory identified a crucial role for IL-21 and STAT3 signaling in NK cell function, survival, metabolism, and proliferation. This enabled large-scale propagation of clinical-grade NK cells for adoptive immunotherapy and novel approaches for genetic modification to enhance functionality. NK cells expanded with this approach have been infused into hundreds of adult and pediatric patients with leukemia, brain tumors, and solid tumors in investigator-initiated Phase I/II trials. Dr. Lee has served on committees for various clinical trial consortiums, societies, and government agencies including the NIH RAC, Gene Transfer Safety Board, and NExTRAC Gene Drive Working Group. His work in cancer immunotherapy and cellular therapy is focused on genetic and non-genetic methods to enhance NK cell function including Cas9/RNP gene editing, AAV gene transfer, epigenetic imprinting, and NK-specific chimeric antigen receptors. His work is supported by NIH, DOD, FDA, and foundation grants with over 160 peer-reviewed publications, 300 filings across 40 patent families, commercial licenses, and biotech startups.https://openworks.mdanderson.org/kleinermanbios/1005/thumbnail.jp
[Letter from Dean A. Clark to L. M. Sellers - June 4, 1939]
No full textLetter from Dr. Dean A. Clark to Dr. L. M. Sellers regarding candidates for the general Jewish Relief Committee and the appointment of a non-Jewish doctor as the Chairman
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Geographic variation in morphology of Agosia chrysogaster, a Sonoran desert cyprinid fish
No full textMorphometric analyses of Agosia chrysogaster (Girard) indicated a northern morph native to Bill Williams, Gila, Sonoyta and de la Concepcion basins of Arizona, New Mexico and Sonora, and a southern form from Willcox Playa of Arizona and Rios Sonora, Yaqui, Mayo, Fuerte and Sinaloa of Sonora and Sinaloa, Mexico. The latter is smaller, and less sexually dimorphic, but has longer pre- and postdorsal body lengths. Populations in the geographically intermediate Rios Sonoyta and Sonora are morphologically intermediate. Males differ more between morphs than do females. Meristic characters show considerable overlap between morphs, but the northern form has higher mean lateral line scale counts. Highly tuberculate nuptial males, characteristic of the northern morph, were not found in the south, nor were "spawning" pits characteristic of breeding activities of the former.
Morphs differ on a multivariate axis on which temporal variation at single localities is also reflected. Distances among some intra-locality samples on this axis were greater than least inter-morph morphological distances. Measures of morphological dissimilarity were weakly correlated with inter-sample differences in elevation, latitude, and longitude, but more highly correlated with an index of hydrologic isolation among localities. Differentiation among basins thus appears to reflect hydrographic isolation, rather than ecological conditions.
Electrophoretic data on A. chrysogaster produced relationships patterns largely incongruent with results of the morphological analyses, and with unexpected geographic area relationships.Integrative Biolog
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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