42 research outputs found
Cortical sources of resting state electroencephalographic rhythms in Parkinson's disease related dementia and Alzheimer's disease
No full text
Long-duration effect and the postsynaptic compartment: study using a dopamine agonist with a short half-life
No full textCOMBINATION OF TWO DIFFERENT DOPAMINE AGONISTS IN THE MANAGEMENT OF PARKINSON’S DISEASE.
No full textRobot-assisted gait training versus treadmill training in patients with Parkinson's disease: a kinematic evaluation with gait profile score
No full textFactors influencing psychological well-being in patients with Parkinson's disease.
No full textBackgroundBoth motor and non-motor symptoms could contribute to significant deterioration of psychological well-being in patients with Parkinson's disease (PD). However, its assessment has been only indirectly evaluated using tools based on health-related quality of life (HRQoL), such as the PDQ-39 scale.ObjectivesTo evaluate psychological well-being in PD using a specific tool of assessment, the Psychological Well-being Scale (PWS), and its clinical correlates.MethodsThis article reports data of patients' perception of health state, as measured by means of the PWS, from an epidemiological, cross-sectional study conducted in Italian PD patients (FORTE Study). We tested possible relationship between well-being and clinical characteristics including fatigue, depression, sleep disruption and HRQoL.Results272 patients completed the PWS questionnaire. Significant and clinically-relevant correlations were found between PWS total score and Parkinson's Fatigue Scale, Beck Depression Inventory, UPDRS Section I, PD Sleep Scale and PDQ-39 for HRQoL scores. Only clinically negligible correlations were found between PWS and motor scores.ConclusionsNon-motor symptoms have a significant impact on psychological well-being in PD patients
Effects of robot assisted gait training in progressive supranuclear palsy (PSP): a preliminary report
No full textBackground and Purpose: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease clinically characterized by prominent axial extrapyramidal motor symptoms with frequent falls. Over the last years the introduction of robotic technologies to recover lower limb function has been greatly employed in the rehabilitative practice. This observational trial is aimed at investigating the changes in the main spatiotemporal following end-effector robot training in people with PSP. Method: Pilot observational trial. Participants: Five cognitively intact participants with PSP and gait disorders. Interventions: Patients were submitted to a rehabilitative program of robot-assisted walking sessions for 45 min, 5 times a week for 4 weeks. Main outcome measures: The spatiotemporal parameters at the beginning (T0) and at the end of treatment (T1) were recorded by a gait analysis laboratory. Results: Robot training was feasible, acceptable and safe and all participants completed the prescribed training sessions. All patients showed an improvement in the gait spatiotemporal index (Mean velocity, Cadence, Step length, and Step width) (T0 vs. T1). Conclusions: Robot training is a feasible and safe form of rehabilitation for cognitively intact people with PSP. The lack of side effects and the positive results in the gait parameter index in all patients support the recommendation to extend the trials of this treatment. Further investigation regarding the effectiveness of robot training in time is necessary. Trial registration: ClinicalTrials.gov NCT01668407
The relation between Parkinson's disease and ageing-Comparison of the gait patterns of young Parkinson's disease subjects with healthy elderly subjects
No full textBACKGROUND:
The gait of healthy elderly and of subjects with Parkinson's disease (PD) displays some common features, suggesting that PD may be a model of ageing.
AIM:
The aim of the study was to quantify highlight the differences and similarities between the gait patterns of young PD and healthy elderly, to uncover if PD could be assumed as a model of ageing.
DESIGN:
An optoelectronic system was used for 3D gait analysis evaluation.
POPULATION AND METHODS:
We compared the gait parameters of 15 young PD (YPD) with the gait of 32 healthy elderly subjects (ES) and 21 healthy subjects age-matched with the PD subjects.
RESULTS:
Common features between YPD and ES were majorly found in the parameters that reflect the presence of an unstable, uncertain gait, and of corrective strategies employed to reduce instability. On the other side, typical features were present in the gait patterns of PD subjects. Conclusion. Our study helped identifying some typical characteristics of the onset disease, and to unravel the symptoms of ageing from those of PD by comparing young PD subjects to elderly healthy subjects. CLINICAL REHABILITATION
IMPACT:
This allows a deeper understanding of the mechanisms underlying the gait in ageing and PD
Cortical sources of resting state electroencephalographic rhythms in Parkinson's disease related dementia and Alzheimer's disease
No full textHere we test the hypothesis that cortical source mapping of resting state electroencephalographic (EEG) rhythms could characterize neurodegenerative disorders inducing cognitive impairment such as Parkinson's disease related dementia (PDD) and Alzheimer's disease (AD)
Prevalence of fatigue in Parkinson disease and its clinical correlates
No full textObjective: To assess in a noninterventional setting the prevalence and severity of fatigue in patients
with Parkinson disease (PD).
Methods: This was a cross-sectional study conducted in Italian patients with PD. Objectives
included the evaluation of the current prevalence and severity of fatigue in patients with PD
measured using the 16-item Parkinson Fatigue Scale (PFS-16), distressing fatigue (defined as
a PFS-16 mean score 3.3). Patients with distressing fatigue were older (p 5
0.044) and had a longer duration of PD (p , 0.0001) than those without distressing fatigue. The
presence of distressing fatigue was associated with higher total Unified Parkinson’s Disease
Rating Scale (UPDRS) scores, poorer quality of life (39-item Parkinson’s Disease Questionnaire
[PDQ-39]), worse social and psychological behaviors, a higher severity of depressive symptoms,
and a higher prevalence of sleep disorders (all p , 0.001). Logistic regression analyses revealed
that higher total UPDRS scores, female sex, depression, sleep disorders, as well as higher UPDRS
activities of daily living scores and PDQ-39 mobility scores increase the likelihood of distressing
fatigue in patients with PD.
Conclusions: Approximately one-third of patients with PD have distressing fatigue, which is significantly
associated with depression and sleep disorders. The fact that the presence of fatigue
worsens patient quality of life supports the need to better diagnose and treat this debilitating
symptom
