1,721,137 research outputs found
Il libraio patriota [dalla fondazione della Zanichelli con Nicola all’estromissione del figlio Cesare]
No full textSi ripercorrono le principali tappe della casa editrice fondata da Nicola Zanichelli e trasformata, dopo la sua morte, in Spa dal figlio Cesare. Nel primo Novecento questo nuovo assetto societario determinava anche un progressivo ridimensionamento del suo ruolo, che diveniva solo esecutivo
Nicola Zanichelli
No full textViene ricostruita sinteticamente l'intera attività di Nicola Zanichelli, prima libraio, poi tipografo ed editore. Nicola Zanichelli è stato il fondatore dell'omonima casa editrice tutt'ora esistente
Graphic novels e fumetti per la divulgazione storica. 2: la Prima guerra mondiale
No full textSi considerano le pubblicazioni riguardanti la Prima guerra mondiale uscite in forma di graphic novel durante il centenario. Varie case editrici, enti e associazioni hanno promosso titoli di questo genere per diffondere la memoria di quella enorme tragedia tra un più ampio pubblico di lettori
L'Astrogallo: piccola editoria di alta qualità
No full textViene analizzata la produzione dell'editrice L'Astrogallo di Ancona, fondata da Carlo Antognini. Le opere edite erano soprattutto libri d'artista che intendevano valorizzare e promuovere la cultura marchigiana
Oxidation and erythropoiesis
Full text linkPurpose of review Erythropoiesis is a complex multistep process going from committed erythroid progenitors to mature red cells. Although recent advances allow the characterization of some components of erythropoiesis, much still remains to be investigated particularly on stress erythropoiesis. This review summarizes recent progresses made to understand the impact of oxidative stress on normal and pathologic erythropoiesis. Recent findings During erythroid maturation, reactive oxygen species might function as second messenger through either transient oxidation of cysteine residues on signaling targets or modulation of intracellular signaling pathways. Thus, in erythropoiesis, efficient cytoprotective systems are required to limit possible reactive oxygen species-related toxic effects especially in stress erythropoiesis characterized by severe oxidation such as b-thalassemia. In addition, prolonged or severe oxidative stress impairs autophagy, which might contribute to the block of erythroid maturation in stress erythropoiesis. Understanding the functional role of cytoprotective systems such as peroxiredoxin-2 or classical molecular chaperones such as the heat shock proteins will contribute to develop innovative therapeutic strategies for ineffective erythropoiesis. Summary We provide an update on cytoprotective mechanisms against oxidation in normal and stress erythropoiesis. We discuss the role of oxidative sensors involved in modulation of intracellular signaling during erythroid maturation process in normal and stress erythropoiesis
Erythrocyte pyruvate kinase activation in red cell disorders.
No full textPurpose of the review. In red cells, pyruvate kinase (PK) is a key enzyme in the final step of glycolytic degradative process which generates a constant energy supply via ATP production. This commentary discusses recent findings on PK activators as new therapeutic option in hereditary red cell disorders such as thalassemic syndromes or sickle cell disease (SCD). Recent findings. Mitapivat and etavopivat are two oral PK activators. Studies in a mouse model for thalassemia have shown beneficial effects of mitapivat on both red cell survival and ineffective erythropoiesis, with an amelioration of iron homeostasis. This was confirmed in a proof-of-concept study in patients with non-transfusion-dependent thalassemias. Both mitapivat and etavopivat have been evaluated in mouse models for SCD, showing an increased 2-3DPG/ATP ratio and a reduction in hemolysis as well as in sickling. These data were confirmed in proof-of-concept clinical studies with both molecules carried in patients with SCD. Summary. Pre-clinical and clinical evidence indicate that PK activators represent new therapeutic option in hemoglobinopathies or SCD. Other red cell disorders such as hereditary spherocytosis or hereditary anemias characterized by defective erythropoiesis might represent additional areas to investigate the therapeutic impact of PK activators
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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