18 research outputs found
Dr. Lester M. Emans: The Educational Transformation of Teachers in Eau Claire in the 1950s and 60s
No full textThe education of teachers is a study that does not receive enough attention in terms of historical and philosophical studies. Thus, in this paper the author will identify the shaping of pre-service education for teachers and note the large transformation of education in the 1950s and 1960s. The author will focus on Lester Emans, who was a crucial supporter and promoter of advancing education for teachers in training. Emans effort helped to transform the educational department at the University of Wisconsin-Eau Claire. Emans enhanced the standards within the curriculum taught at the University by implementing a lab school on campus, improving Wisconsin's values of teaching, restructuring the secondary education department and enhancing the student teaching program at Eau Claire. His determinations to develop the educational system for future teachers has proven, in more ways than one, beneficial to the education department at the University of Wisconsin-Eau Claire and still resonates today
The effects of a lean transition on process times, patients and employees
No full textPurpose - Treatment delays must be avoided, especially in oncology, to assure sustainable high-quality health care and increase the odds of survival. The purpose of this paper is to hypothesize that waiting times would decrease and patients and employees would benefit, when specific lean interventions are incorporated in an organizational improvement approach. Design/methodology/approach - In 2013, 15 lean interventions were initiated to improve flow in a single radiotherapy institute. Process/waiting times, patient satisfaction, safety, employee satisfaction, and absenteeism were evaluated using a mixed methods methodology (2010-2014). Data from databases, surveys, and interviews were analyzed by time series analysis, chi(2), multi-level regression, and t-tests. Findings - Median waiting/process times improved from 20.2 days in 2012 to 16.3 days in 2014 (p Originality/value - Combining specific lean interventions with an organizational improvement approach improved waiting times, patient safety, employee satisfaction, and absenteeism on the short term. Continuing evaluation of effects should study the improvements sustainability
Context Clues as an Aid to the Reader
No full textContext clues have been referred to as the most important single aid to word perception. The author proposes a simplified schema to organize context clues according to three categories for perception of printed words- meaning clues, language clues, and organization clues-and within each of the categories, describes a number of types of context clues and gives examples
The author as a new Hercules : self-reflection and mythological allusions in the work of Jean Paul
No full textSeverity of Diabetes Mellitus and Total Hip or Knee Replacement
No full textPermissions RESEARCH ARTICLE: OBSERVATIONAL STUDY Severity of Diabetes Mellitus and Total Hip or Knee Replacement A Population-Based Case–Control Study Nielen, Johannes T.H. MSc; Emans, Pieter J. PhD; Dagnelie, Pieter C. PhD; Boonen, Annelies PhD; Lalmohamed, Arief PhD; de Boer, Anthonius PhD; van den Bemt, Bart J.F. PhD; de Vries, Frank PhD Editor(s): Roever., Leonardo Author Information Medicine 95(20):p e3739, May 2016. | DOI: 10.1097/MD.0000000000003739 OPEN SDC Metrics Abstract It is generally thought that people with diabetes mellitus (DM) are more likely to suffer from osteoarthritis (OA) due to an increased body mass index (BMI), resulting in mechanical destruction of cartilage. However, previous studies have suggested a coexisting metabolic causality. To evaluate the risk of hip or knee replacement, as a proxy for severe OA, in patients with DM. We additionally evaluated the risk of total joint replacement (TJR) with various proxies for increased DM severity. A population-based case–control study was performed, using the Clinical Practice Research Datalink (CPRD). Cases (n = 94,609) were defined as patients >18 years who had undergone TJR between 2000 and 2012. Controls were matched by age, gender, and general practice. Conditional logistic regression was used to estimate the risk of total knee (TKR) and total hip replacement (THR) surgery associated with use of antidiabetic drugs (ADs). We additionally stratified current AD users by proxies for DM severity. Current AD use was significantly associated with a lower risk of TKR (OR = 0.86 (95% CI = 0.78–0.94)) and THR (OR = 0.90 (95% CI = 0.82–0.99)) compared to patients not using ADs. Moreover, risk of TKR and THR was decreased with increasing HbA1c. This study does not support the theory that DM patients are more likely to suffer from severe OA as compared to patients without diabetes. Moreover, risk of severe OA necessitating TJR decreases with increasing DM severity. This is possibly due to dissimilarities in methodology, a decrease in eligibility for surgery, or variability of OA phenotypes
On the boundary semantics and differentiation forms
No full textThe article studies origin and transformation of the boundary notion, demonstrates the difficulty of its definition. The work provides a historical overview of boundary semantics change in German language, investigates the notion history. The author shows the differentiation act to be a source of the philosophical thought in Antiquity, and a source of the scientific one in Modern time. The article investigates the transformation of the boundary philosophical semantics from the Antiquity to the present days. Special attention is devoted to boundary cultural aspects
The Book as a landscape
No full textThere is a long tradition of regarding landscapes as texts and texts as landscapes. Characterizing visually experienced nature as a text implies stressing its meaningfulness, its character as a message or an expression. According to an old metaphor that was highly esteemed in medieval Christian culture as well as in early modem science, nature itself is a divine message addressed to mankind, analogously to the holy scriptures, revealing the will of God as the superior "author" to those who are able to decipher the signs. As a consequence of the process of secularization, art gains authority over the signs of nature, and it is the artist who creates messages by composing the elements of the visual world. The idea of interpreting texts as landscapes seems less evident at the first moment; it implies the notion of texts and landscapes as artificial products which depend on an individual human subject's intentions
E.T.A. Hoffmanns »Kater Murr«
No full textWith the ‘Lebens-Ansichten des Katers Murr nebst fragmentarischer Biographie des Kapellmeister Johannes Kreisler in zufälligen Makulaturblättern’ (1819/1921), E.T.A. Hoffmann, the author, composer, illustrator and legal scholar, created a piece of writing that can be considered one of the most groundbreaking novels of the 19th century. This volume assembles new readings that examine Hoffmann's Kater Murr from comparative, musicological and theatre theory perspectives. It also explores poetological (for Kater Murr that means consistently focusing on the materiality of its artistic production) as well as media-aesthetic and cultural studies approaches. With contributions by Prof. Dr. Lutz Ellrich, Prof. Dr. Achim Geisenhanslüke, Dr. Irmtraud Hnilica, Dr. Vanessa Höving, Prof. Dr. Claudia Liebrand, Prof. Dr. Christine Lubkoll, Prof. Dr. Frederike Middelhoff, Prof. Dr. Harald Neumeyer, Prof. Dr. Marion Schmaus, Prof. Dr. Monika Schmitz-Emans, Dagmar Wahl and Prof. Dr. Thomas Wortmann.PublishedE.T.A. Hoffmann, der Autor, Komponist, Zeichner und Jurist, hat mit den „Lebens-Ansichten des Katers Murr nebst fragmentarischer Biographie des Kapellmeister Johannes Kreisler in zufälligen Makulaturblättern“ (1819/1921) einen Text vorgelegt, der als einer der innovativsten Romanprojekte des 19. Jahrhunderts anzusehen ist. Der Band versammelt neue Lektüren, die Hoffmanns Kater Murr aus komparatistischer, musik- und theatertheoretischer Sicht in den Blick nehmen. Sowohl poetologische (das heißt für den Kater Murr immer auch auf die Materialität der künstlerischen Produktion zielende) als auch medienästhetische und kulturwissenschaftliche Zugänge werden erprobt. Mit Beiträgen von Prof. Dr. Lutz Ellrich, Prof. Dr. Achim Geisenhanslüke, Dr. Irmtraud Hnilica, Dr. Vanessa Höving, Prof. Dr. Claudia Liebrand, Prof. Dr. Christine Lubkoll, Prof. Dr. Frederike Middelhoff, Prof. Dr. Harald Neumeyer, Prof. Dr. Marion Schmaus, Prof. Dr. Monika Schmitz-Emans, Dagmar Wahl und Prof. Dr. Thomas Wortmann
Vesicular traffic in polarized epithelial cells : identification and characterization of general and epithelial specific factors
No full textPolarized epithelial cells are differentiated into apical and basolateral plasma membrane domains separated by tight junctions. The apical cell surface usually faces the external milieu, the basolateral domain provides cell-cell and cell-substratum contact and is surrounded by body fluids. In Madin-Darby canine kidney (MDCK) cells the unique protein and lipid composition of the two surface domains is generated by sorting in the trans-Golgi network (TGN) and selective delivery to the cell surface by a vesicular carrier mechanism. Sorting to the apical plasma membrane has been proposed to be mediated by a co-clustering of proteins and glycosphingolipids in the TGN. In order to identify the molecular machinery involved in sorting and transport of apically destined cargo I have characterized glycolipid-enriched, detergent-insoluble complexes from MDCK cells. Several proteins of the complexes were found to be components of immunoisolated apical and basolateral exocytic carrier vesicles thus representing prime candidates for the sorting machinery. By using preparative two-dimensional (2-D) gel electrophoresis and the information of 2-D gel databases I was able to identify and to purify several of these proteins for peptide microsequencing. Subsequently, I isolated the cDNAs encoding VIP36 (VesicularIntegral Membrane Protein of 36 kDa) and annexin XIIIb. VIP36 is a glycolipid raft component present in apical and basolateral vesicular carriers. The protein had a significant sequence similarity to leguminous plant lectins. VIP36 was shown to be an integral membrane protein localized to the Golgi apparatus and the cell surface, presumably recycling between them. The protein might bind to sugar residues of glycoproteins, glycolipids or glycosylphosphatidyl inositol-anchored proteins and provide a link between the luminal face of glycolipid rafts and the cytosolic vesiculation machinery. A mammalian homologue of VIP36 is localized to the early secretory pathway. This suggests that a new family of hitherto unknown animal lectins may be involved in the sorting of saccharide bearing molecules throughout the biosynthetic pathway. Annexin XIIIb is a component enriched in apical exocytic carrier vesicles and is a new member of an epithelial specific sub-family of annexins. Annexin XIIIb was localized to the apical cell surface and vesicular structures in MDCK cells. Annexins are implicated in membrane-membrane interactions and annexin XIIIb may be involved in delivery to the apical cell surface in MDCK cells. With the identification of these new, general and epithelial specific factors it will be possible to gain access to additional components of the epithelial sorting and targeting machinery to elucidate the molecular mechanisms responsible for protein and lipid sorting and vesicular transport
Measured vs simulated portal images for low MU fields on three accelerator types: Possible consequences for 2D portal dosimetry
No full textPurpose: As external beam treatment plans become more dynamic and the dose to normal tissue is further constrained, treatments may consist of a larger number of beams, each delivering smaller doses (or monitor units, MU), in, e.g., volumetric modulated arc therapy (VMAT). Electronic portal imaging devices (EPID) may be used to verify external beam treatments on integrated fractions as well as in a more time dependant manner such as field by field. For treatment verification performed during a fraction (e.g., individual fields or VMAT control points), the lower limit of EPID measurement capability becomes important. The authors quantified the signal and timing accuracy of EPID images for low MU intensity modulated radiotherapy (IMRT) and conformal fields. Methods: EPID images were collected from three different vendor's accelerators for low MU fields and compared to expected images. Simulations were performed to replicate the EPID acquisition pattern and to enhance the understanding of EPID readout schemes. Results: Large discrepancies between observed and predicted images were noted due to an under-response to single low MU fields. It is shown that a variability of up to 37% can be observed for low MU fields in clinically used EPID acquisition modes and that the majority of this variability can be accounted for by the readout scheme, integration, and timing of EPID acquisitions. Simulations have confirmed the causes of the discrepancies. The occurrence and extent of the variation has been estimated for clinical settings. Conclusions: Incorrect absolute EPID signals collected for low MU fields in external beam treatments will negatively affect quantitative applications such as individual field based EPID dosimetry, typically appearing as an underdose, unless corrections to currently employed EPID readout schemes are made
