1,721,228 research outputs found
Influence of bar diameter on low-cycle fatigue degradation of reinforcing bars
Get PDFThis paper reports the results of 120 low-cycle fatigue tests on steel reinforcing bars with varying slenderness ratios at varying strain amplitudes. The failure modes of the fractured bars were investigated through analysis of the fracture mechanisms of bars. The results of experimental testing were used to update empirical models of low-cycle fatigue life for such bars. The newly improved empirical models were then incorporated into a recently developed constitutive material model that accounts for bar buckling and fatigue. The experimental results show that the size effect is significant for short steel reinforcing bars where there is no buckling. The results also show that as the slenderness ratio of the steel reinforcing bars increases, the influence of the bar diameter on low-cycle fatigue reduces.</p
COMPLETE GENOME SEQUENCING OF A HUMAN B3 THYMOMA
No full textBackground: Molecular biology of thymomas is poorly understood. We sequenced the whole genome of one B3 thymoma and the matched normal DNA from blood sample of the same patient.
Methods: Frozen primary tumor and blood were collected from a Caucasian 53 female with B3/stage IVA thymoma after surgery. DNA and RNA were extracted using All Prep kit (Qiagen). Array Comparative genomic hybridization (CGH) was performed on 180K array (Agilent) and Agilent platform. Transcriptome sequencing was performed using 72bp paired-end sequencing and 2 flow cell lanes of genome analyzer II (Illumina). Whole genome sequencing (WGS) was performed on tumor and normal DNA using Complete Genomic Inc platform.
Results: In the WGS analysis, a total of 222.02 gigabases (Gb) of sequence were mapped (95.3% of genome called) for the tumor sample and 234.53 Gb (96.4% of genome called) for the matched normal control. Sequence reads were aligned to a human reference genome (NCBI Build 37) and a local de novo assembly was used to call and score variants. Both array CGH and copy number (CN) aberrations estimated from WGS showed CN imbalance patterns comparable with those previously described for B3 thymomas with CN gain of chromosomes 1q, 5, 7 and X and CN loss of 3p, 6, 11q42.2-qter and q13. We observed 3,096,049 single nucleotide variations (SNVs) in the tumor and 3,314,611 in the normal DNA. The transition/transversion ratio was 2.14 and 1.83 for germ line and somatic SNVs, respectively. Somatic SNVs were defined as those variations present in tumor but not normal matched DNA. We observed 5946 diploid somatic indels and 6530 SNVs, of which 43 and 83 were within exonic regions, respectively. 29 indels and 25 SNVs were not previously described as SNPs, nor in segmental duplication, or synonymous mutations. By comparison with the transcriptome sequencing data of the same tumor sample, we confirmed the expression of 6 mutated genes, while for 45 mutated genes there were not enough reads to confirm the calls.
Conclusion: WGS and accompanying transcriptome sequencing offer an unprecedented view of the genome of a thymoma cancer patient sample. We are actively engaged in determining the potential functional significance of the genomic variants in the context of transcriptome sequencing and copy number variation to gather clues as to the underlying biology driving this relatively rare tumor type
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Impact of corrosion on low-cycle fatigue degradation of reinforcing bars with the effect of inelastic buckling
Get PDFThe combined effect of inelastic buckling and chloride induced corrosion damage on low-cycle high amplitude fatigue life of embedded reinforcing bars in concrete is investigated experimentally. A total of forty eight low-cycle fatigue tests on corroded reinforcing bars varied in percentage mass loss, strain amplitudes and buckling lengths are conducted. The failure modes and crack propagation are investigated by fractography of fracture surfaces using scanning electron microscope. The results show that the inelastic buckling, percentage mass loss and nonuniform corrosion pattern are the main parameters affecting the low-cycle fatigue life of reinforcing bars. It was found that the fatigue life of corroded reinforcing bars combined with inelastic buckling has a significant path dependency. The results show that in some cases the number of cycles to failure of corroded bars under constant amplitude fatigue test is increased
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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