13,079 research outputs found
Father Andrew Mullen 1790-1818: a study in early nineteenth century spirituality
No full textThis thesis is laid out in three parts: Part I. The life and death of Andrew Mullen. The life is based, to a large extent, on a long letter to his mother, Catherine Mullen, dated 7 January 1810. The letter gives a definite insight into his spirituality based on his membership of the Archconfraternity of the Blessed Sacrament. There is a hint that he had a premonition of an early death. Part II. The burial of Andrew Mullen and the immediate cult to him This is based on documentary evidence. Part III. Most of this part is a catalogue of testimonies taken from 1993 onwards. Then there is the conclusion on the popular devotion to Andrew Mullen stressing the theological aspect of the subject. In the course of writing the thesis it was decided to separate the documentary evidence from the oral tradition. This was advantageous in developing the thesis, and the documents provided a secure basis for the oral tradition. Two pieces of information were found in March 1997. They are death notices: 2 January 1819, The Leinster Journal and 7 January 1819, The Car low Morning Post. There is a slight discrepancy between the two on the date of his death. Also this discrepancy shows a slight difference from the date of the tombstone
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Consumer-Driven Operations: Empirical and Experimental Studies in Demand Models
No full textThe new selling techniques enabled by information technologies in today's marketplaces, such as online sales channels, search portals, and review platforms, changed the consumer-driven demand in many ways. Unlike traditional retail competition, mostly driven by product attributes (e.g., quality, price, etc.), these selling techniques based on information technologies have become more important to consider customer behavior and its resulting effect in shaping demand, in order for firms to better plan their operational strategies. In this dissertation, we investigate different sources of demand uncertainty and obtain insights into operations of the firms competing in the current marketplace. We develop methods for more accurate estimations of demand in the presence of downstream customers' choice behavior or social interactions. We adopt the Markov Chain based model to understand customer demand and validate the model using human-subject experiment and field data. We also conduct empirical research to capture online browsing behavior of consumers and provide implications to operational managers.
This dissertation consists of three chapters.
- Chapter 1: The Effect of Social Information on Demand in Quality Competition. This is joint work with Professor Vishal Gaur and Professor Andrew Davis
- Chapters 2: Predicting Order Variability in Inventory Decisions: A Model of Forecast Anchoring. This is joint work with Professor Andrew Davis and Professor Li Chen
- Chapter 3: Predicting Purchase Propensity from Online Browsing Behavior. This is joint work with Professor Vishal Gaur
The three chapters are self-contained but are related to one another: Chapter 1 investigates the impact of social information on demand uncertainty using experimental work, Chapter 2 explores the sources of amplified demand uncertainty from the downstream buyers' inventory decisions, and Chapter 3 empirically explores the effect of online browsing behavior on demand prediction and is a work-in-progress. All these chapters commonly focus on the behavioral sources of demand endogeneity. Therefore, this dissertation aims to contribute to improve the accuracy of demand estimation by incorporating those behavioral factors into the models in Operations
Propositions in the Making Experiments in a Whiteheadian Laboratory
No full textPropositions in the Making articulates the newest reaches of Whiteheadian propositions for a postmodern world. It does so by activating interdisciplinary lures of feeling, living, and co-creating the world anew. Rather than a “logical assertion,” Whitehead described a proposition as a “lure for feeling” for a collectivity to come. It cannot be reduced to the verbal content of logical justifications, but rather the feeling content of aesthetic valuations. In creatively expressing these propositions in wide relevance to existential, ethical, educational, theological, aesthetic, technological, and societal concerns, the contributors to this volume enact nothing short of “a Whiteheadian Laboratory.
Structure Of 18'-Epivinblastine
No full textMethyl {3aR-[3a-alpha,4-beta,5-beta,5a-beta,9(3R*,-5S*,7R*,9R*),10bR,13a-alpha]}-4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-lH-indolizino-[8,1-c,d]carbazole-5-carboxy?? late methanol solvate, C46H58N4O9.2CH3OH (1), M(r) = 875.07, monoclinic, P2(1), a = 10.2759 (12), b = 22.353 (3), c = 10.4051 (12) angstrom, beta = 106.502 (9)-degrees, V = 2291.6 (5) angstrom 3, Z = 2, D(x) = 1.27 g cm-3, Mo K-alpha radiation, lambda = 0.7107 angstrom, mu = 0.8397 cm-1, F(000) = 940, T = 198 K, R = 0.0470 for 2751 reflections, F(o) greater-than-or-equal-to 4-sigma-(F(o)). The C ring of the vindoline moiety is in the boat conformation with the hydroxy group and the tertiary N in the bowsprit positions resulting in a fairly short intramolecular hydrogen-bonding interaction. The relevant parameters for O3-H3...N9 are O...N 2.651 (6), H...N 1.94 (5) angstrom and O-H...N 147 (5)-degrees. The D and E rings are in the sofa and envelope conformations, respectively. The piperidine ring of the catharanthine portion of the molecule assumes the chair conformation while the conformation of the azacyclononene ring is a boat-chair. An intramolecular hydrogen bond between the indolino NH of the catharanthine moiety and methoxy O (O25) of the vindoline moiety is also observed. The relevant parameters for N16'-H16'...O25 are N...O 2.827 (6), H...N2.14 (6) angstrom and O-H...N 136 (5)-degrees.National Institutes of Health (GM 29801)ChemistryBiochemistr
Lead optimisation: what you should know!
No full textLead Optimisation (LO) is a critical part of the drug discovery process as it is the part where all efforts that go into earlier parts of the process (Target Identification, HTS, Hit-to-Lead, Lead Identification) are crystallised into a single compound, the candidate drug. The optimisation phase is like a treasure hunt, and discovery projects can take many paths to discover their treasured molecule. In this chapter we have chosen to focus on the practicalities of how the LO project can be organised, and what different property issues the project may face as it attempts to find an efficient path forward to find a suitable candidate drug for development. This multiparameter optimisation dance can have many issues, often interconnected. We discuss approaches to many of these problems and offer advice on how project members should think about tackling issues in a holistic way. In this way we hope to support projects in understanding the right issues to tackle at the right time. We offer some tips, and examples, of successes, and suggest that identifying the issue to tackle is key to establishing robust hypotheses to test and so drive projects forward. Our goal in this chapter is to aid project thinking about the best way forward
Experimental Studies on Supply Chain Contracting
No full text217 pagesSupply chain contracting is a classic topic in operations management. While the traditional literature typically assumes a rational decision-maker, the behavioral operations management literature has shown that human decision-makers may exhibit behavioral biases and deviate from optimality. Given that many operational decisions are made by managers in practice, it is essential to understand the role of behavioral factors. This dissertation experimentally studies three problems in supply chain contracting, each of which is summarized as follows. The first chapter focuses on inventory sharing, comparing alternative inventory-sharing strategies in a two-tier supply chain with an upstream manufacturer and two downstream retailers. In one setting, retailers act as if they are centralized and use a single quantity to fulfill joint demand. In the other, retailers are decentralized and face separate demands, but they can transfer inventory after demands are realized. In the latter, decentralized scenario, whether the manufacturer or retailers have decision authority over the inventory transfer price is also considered. By conducting lab experiments, this work shows that when the retailers are decentralized and the manufacturer sets the transfer price, both retailers and the manufacturer earn higher profits than in the centralized retailer strategy, which runs counter to theory. This chapter is a joint work with Andrew Davis and Douglas Thomas (University of Virginia). The second chapter turns to supply chain finance and investigates a trade credit contract between a supplier and a financially distressed retailer. The supplier sets a wholesale price for the retailer, who begins with some initial capital and orders from the supplier. The retailer will purchase through trade credit if the initial capital is insufficient and repay the supplier after demand realization. The retailer will go bankrupt if the realized demand is too low. Experimental results suggest that when retailers' risk is medium or high, they significantly understock to maintain lower risk and suppliers offer lower prices (but not necessarily less risk) to retailers. When retailers' risk is very low, they slightly overstock, which brings them additional bankruptcy risk. This chapter is a joint work with Andrew Davis and Kyle Hyndman (University of Texas at Dallas). The third chapter studies management of responsible sourcing and reputation risk in a two-tier supply chain consisting of an upstream supplier and a downstream buyer. The supplier faces random cost shock which can be mitigated by exerting effort. The supplier's effort has two types which differ in cost and whether it complies with the buyer's responsible standards. A non-compliant effort will incur extra reputation loss for the buyer. The buyer offers a risk-sharing contract: a wholesale price and sharing some of the cost shock with the supplier. While the theory suggests that the supplier always prefers non-compliant effort, experimental results show that 25.82% of suppliers choose compliant effort. More surprisingly, the effort choice is driven only by the wholesale price but not by the cost-shock sharing, which is inconsistent with the theory. This chapter is a joint work with Andrew Davis and Li Chen
Reply to L. Marandino et al.
No full textAbstract not availableMartin R. Stockler, MBBS, MSc, and Andrew J. Martin, PhD, Haryana M. Dhillon, BSc, MA, PhD, Ian D. Davis, MBBS, PhD, Christopher J. Sweeney, MBB
sj-docx-1-gut-10.1177_26345161231188677 – Supplemental material for Survival Trends and Profiling of Gastric Mixed Adenoneuroendocrine Carcinoma (gMANEC) in the Current Era
No full textSupplemental material, sj-docx-1-gut-10.1177_26345161231188677 for Survival Trends and Profiling of Gastric Mixed Adenoneuroendocrine Carcinoma (gMANEC) in the Current Era by Shreya Gupta, James D. McDonald, Alexander J. Rossi, Jonathan M. Hernandez, Jeremy L. Davis and Andrew M. Blakely in Foregut</p
sj-pptx-2-gut-10.1177_26345161231188677 – Supplemental material for Survival Trends and Profiling of Gastric Mixed Adenoneuroendocrine Carcinoma (gMANEC) in the Current Era
No full textSupplemental material, sj-pptx-2-gut-10.1177_26345161231188677 for Survival Trends and Profiling of Gastric Mixed Adenoneuroendocrine Carcinoma (gMANEC) in the Current Era by Shreya Gupta, James D. McDonald, Alexander J. Rossi, Jonathan M. Hernandez, Jeremy L. Davis and Andrew M. Blakely in Foregut</p
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