387 research outputs found
Can we understand God\u27s justice? Is the word, Judgment a bad word? #God #Justice #Mercy #Theology
No full textProfessor Richard Davidson talks about justice and judgment and how God achieves justice and mercy. In addition, a prosecutor joins the deep discussion. This is one amazing talk
Bilingual Latino Students Learn Science for Fun While Developing Language and Cognition: Biophilia at a La Clase Mágica Site
No full textIn this article, the author suggests that children’s natural inclination to explore nature, or biophilia, can be explored as a factor that encourages both cognitive engagement and language development.  The author summarizes the types of scientific inquiries that bilingual elementary students and their university partners engaged in when guided to design their own projects at a predominantly Mexican-American school.  Children inquiries took place at a La Clase Mágica site, an after school program in which university undergraduates, faculty, bilingual children, and the community come together with the purpose of learning and exploring technology through interdisciplinary methodologies.  The findings indicate that children overwhelmingly chose living organisms and life-like processes as the focus of their inquiries.  The author presents the work of an exemplary dyad to illustrate how children engaged in scientific inquiry while developing language and complex thinking
Impact of the Pandemic on Women in the Workplace
No full textChair: Christina M. Low Kapalu PhD, Children’s Mercy Kansas City Participant/1st Author Christina M. Low Kapalu PhD, Children’s Mercy Kansas City Challenges Faced and Strengths of Mothers in the Workforce Participant/1st Author Idia B. Thurston PhD, Texas A&M University Black Women in the Workplace Participant/1st Author Jessica M. Valenzuela PhD, Nova Southeastern University Impact of the Pandemic on Women in the Workplace Participant/1st Author Lori E. Crosby PsyD, Cincinnati Children’s Hospital Medical Center Creating Safe and Respectful Workplaces Discussant Melissa Santos PhD, Connecticut Children’s Medical Center, Hartford, C
The sacrament of confession as a gift of mercy and reconciliation
No full textV nalogi avtor predstavi zakrament spovedi skozi oči mistikinje Adrienne von Speyr, cerkvenega učiteljstva po Katekizmu katoliške Cerkve, Antona Strleta, sv. Janeza Pavla II., sv. Favstine Kowalske in nekaterih drugih avtorjev.
Osrednji del naloge je sestavljen iz štirinajstih delov, ki pa so ena celota. V prvem in drugem delu se avtor osredotoči na Adrienne von Speyr, ki spoved osredišči na Jezusa Kristusa, kot zgled spovedanca. V tretjem in četrtem delu avtor kratko predstavi zakrament sprave in kako je se je razvijal skozi zgodovino. V petem delu prikaže odnos Cerkve do spovedi, do spovedanca in se pri tem opira predvsem na delo sv. Janeza Pavla II. V nadaljevanju avtor predstavi dinamiko greha, kajti brez greha tudi spoved ni potrebnatu se opira predvsem na Katekizem katoliške Cerkve. Nato obravnava temeljne drže spokornih dejanj po Antonu Strletu. V osmem in devetem delu se avtor osredotoči na svetopisemski temelj Božjega usmiljenja, pravičnosti in odpuščanja, v nadaljevanju pa spregovori o »sodišču« Božjega usmiljena po sv. Favstini Kowalski, ki zelo slikovito spregovori o spovedi. Potem predstavi, kdo je lahko delivec zakramenta spovedi in kakšni so njeni učinki. Tudi tu se opira predvsem na učiteljstvo katoliške Cerkve. V dvanajstem poglavju avtor spregovori o odpustkih, ki so bili v zgodovini zelo pereča tema, predvsem zaradi napačnega poimenovanja in razumevanja. Pri tem delu se avtor opira na Antona Strleta. V zaključku osrednjega dela pa nam avtor osvetli samo obhajanje zakramenta spovedi ter praktične napotke za dobro opravljeno spoved. Pri tem se opira predvsem na priporočila in napotke iz Katekizma.
Namen dela je, da bi ponovno odkrili bogastvo zakramenta spovedi in pomembnosti le-te v našem življenjuspoved je dar, ki nam je podarjen in ni nekaj strašnega ali nepomembnega, ampak intimno, veselo srečanje z Jezusom Kristusom, ki je vir naše svobode in sreče.The author of the given work is presenting the sacrament of confession through the eyes of mystic Adrienne von Speyr, of the Magisterium of Catholic Church, of the Catechism, Anton Strle, st. pope John Paul II., st. Faustina Kowalska, and some other authors.
The central part of thesis consists of fourteen chapters, which all represent one whole. In the first and the second chapter, author focuses on Adrienne von Speyr who centered Jesus Christ as an example of confessor. In the third and fourth, author briefly presents the sacrament of reconciliation and how it has evolved throughout history. The fifth chapter shows the relationship betwen Church, confession and penitent, relying primarily on the work of pope st. John Paul II. Here the author presents the dynamics of sin, because confession itself is not required if there is no sin to be forgiventext in this part is based mainly on the Catechism of the Catholic Church. It then looks at basic postures of penitential acts as described by Anton Strle. In the eighth and ninth chapter, the author focuses on biblical foundation of God\u27s mercy, justice and forgiveness and afterwards writes about the "court of God\u27s mercy" as St. Faustina Kowalska, picturesquely speaks about confession. After that we come to know who can be a minister of the sacrament of confession and what its effects are. Here too, it relies primarily on the Magisterium of the Catholic Church. In the twelfth chapter the author speaks about the indulgences, a very pressing topic in the history, mainly because of an incorrect naming and understanding of this grace. At this point, the author relies on Anton Strle. In conclusion of this central part author illuminates the celebration of the sacrament of healing alone and bare practical guidance for a good confession as presented and recommended in the Catechism of Catholic Church.
The purpose of the work is to rediscover the richness and importance of the sacrament of confession it in our lives. Confession is a gift donated to us and not something terrible or terrifying, but an intimate, joyful encounter with Jesus Christ, the true source of our freedom and happiness
Pathogenesis of the deafness-associated A1555G mitochondrial DNA mutation
No full textThe pathogenic mechanisms of the A1555G mitochondrial DNA mutation in the 12S rRNA gene, associated with maternally inherited sensorineural deafness, are largely unknown. Previous studies have suggested an involvement of nuclear factor(s). To address this issue cybrids were generated by fusing osteosarcoma cells devoid of mtDNA with enucleated fibroblasts from two genetically unrelated patients. Furthermore. to determine the contribution, if any, of the mitochondrial and nuclear genomes, separately or in combination, in the expression of the disease phenotype, transmitochondrial fibroblasts were constructed using control and patient's fibroblasts as nuclear donors and homoplasmic mutant or wild-type cybrids as mitochondrial donors. Detailed analysis of mutant and wild-type cybrids from both patients and transmitochondrial fibroblast clones did not reveal any respiratory chain dysfunction suggesting that, if nuclear factors do indeed act as modifier agents, they may be tissue-specific. However, in the presence of high concentrations of neomycin or paromomycin. but not of streptomycin. mutant cells exhibit a decrease in the growth rate, when compared to wild-type cells. The decrease did not correlate with the rate of synthesis or stability of mitochondrial DNA-encoded subunits or respiratory chain activity. Further studies are required to determine the underlying biochemical defect. (C) 2002 Elsevier Science (USA). All rights reserved
A comparison of comprehension abilities outlined in teachers' manuals and measured by reading tests, 1966
No full textA homoplasmic mitochondrial transfer ribonucleic acid mutation as a cause of maternally inherited hypertrophic cardiomyopathy
No full textOBJECTIVES The purpose of this study was to understand the clinical and molecular features of familial hypertrophic cardiomyopathy (HCM) in which a mitochondrial abnormality was strongly suspected. BACKGROUND Defects of the mitochondrial genome are responsible for a heterogeneous group of clinical disorders, including cardiomyopathy. The majority of pathogenic mutations are heteroplasmic, with mutated and wild-type mitochondrial deoxyribonucleic acid (mtDNA) coexisting within the same cell. Homoplasmic mutations (present in every copy of the genome within the cell) present a difficult challenge in terms of diagnosis and assigning pathogenicity, as human mtDNA is highly polymorphic. METHODS A detailed clinical, histochemical, biochemical, and molecular genetic analysis was performed on two families with HCM to investigate the underlying mitochondrial defect. RESULTS Cardiac tissue from an affected child in the presenting family exhibited severe deficiencies of mitochondrial respiratory chain enzymes, whereas histochemical and biochemical studies of the skeletal muscle were normal. Mitochondrial DNA sequencing revealed an A4300G transition in the mitochondrial transfer ribonucleic acid (tRNA)(Ile) gene, which was shown to be homoplasmic by polymerase chain reaction/restriction fragment length polymorphism analysis in all samples from affected individuals and other maternal relatives. In a second family, previously reported as heteroplasmic for this base substitution, the mutation has subsequently been shown to be homoplasmic. The pathogenic role for this mutation was confirmed by high-resolution Northern blot analysis of heart tissue from both families, revealing very low steady-state levels of the mature mitochondrial tRNA(Ile). CONCLUSIONS This report documents, for the first time, that a homoplasmic mitochondrial tRNA mutation may cause maternally inherited HCM. It highlights the significant contribution that homoplasmic mitochondrial tRNA substitutions may play in the development of cardiac disease. A restriction of the biochemical defect to the affected tissue has important implications for the screening of patients with cardiomyopathy for mitochondrial disease. (C) 2003 by the American College of Cardiology Foundation
Off with their heads : terrorism and electoral support for capital punishment in Australia
No full textTerrorist attacks such as the attacks on the World Trade Centre in September 2001 have generated new interest in the debate on capital punishment. It has been suggested that support for the death penalty could be higher in the wake of terrorist activity. Using data from the Australian Election Study we investigate voters' attitudes towards capital punishment. Paradoxically, overall support for the death penalty at the 2001 Federal election was lower than at previous elections. In this paper we utilise a treatments effects models to model the determinants of those attitudes and to investigate the impact of terrorism on support for the death penalty at the 2001 Federal election. In particular, we address the question of whether voters who felt terrorism was an important issue had higher levels of support for the death penalty than voters who did not feel that terrorism was important.Australian Research Council grant DP044984
Off with their heads: Terrorism and electoral support for capital punishment in Australia
No full textRecent terrorist attacks such as the attacks on the World Trade Centre in September 2001 have generated new interest in the debate on capital punishment. It has been suggested that support for the death penalty could be higher in the wake of terrorist activity. Using data from the Australian Election Study we investigate voters' attitudes towards capital punishment. Paradoxically, overall support for the death penalty at the 2001 Federal election was lower than at previous elections. In this paper we utilise both simultaneous binary probit and treatment effects models to model the determinants of those attitudes and to investigate the impact of terrorism on support for the death penalty at the 2001 Federal election. In particular, we address the question of whether voters who felt terrorism was an important issue had higher levels of support for the death penalty than voters who did not feel that terrorism was importantsimultaneous binary probit, treatment effects models
Defects of mtDNA replication impaired mitochondrial biogenesis during Trypanosoma cruzi infection in human cardiomyocytes and Chagasic patients: The role of Nrf1/2 and antioxidant response
No full textMitochondrial dysfunction is a key determinant in chagasic cardiomyopathy development in mice; however, its relevance in human Chagas disease is not known. We determined if defects in mitochondrial biogenesis and dysregulation of peroxisome proliferator-activated receptor gamma (PPARγ) coactivator-1 (PGC-1)-regulated transcriptional pathways constitute a mechanism or mechanisms underlying mitochondrial oxidative-phosphorylation (OXPHOS) deficiency in human Chagas disease. We utilized human cardiomyocytes and left-ventricular tissue from chagasic and other cardiomyopathy patients and healthy donors (n>6/group). We noted no change in citrate synthase activity, yet mRNA and/or protein levels of subunits of the respiratory complexes were significantly decreased in Trypanosoma cruzi-infected cardiomyocytes (0 to 24 hours) and chagasic hearts. We observed increased mRNA and decreased nuclear localization of PGC-1-coactivated transcription factors, yet the expression of genes for PPARγ-regulated fatty acid oxidation and nuclear respiratory factor (NRF1/2)-regulated mtDNA replication and transcription machinery was enhanced in infected cardiomyocytes and chagasic hearts. The D-loop formation was normal or higher, but mtDNA replication and mtDNA content were decreased by 83% and 40% to 65%, respectively. Subsequently, we noted that reactive oxygen species (ROS), oxidative stress, and mtDNA oxidation were significantly increased, yet NRF1/2-regulated antioxidant gene expression remained compromised in infected cardiomyocytes and chagasic hearts. The replication of mtDNA was severely compromised, resulting in a significant loss of mtDNA and expression of OXPHOS genes in T cruzi-infected cardiomyocytes and chagasic hearts. Our data suggest increased ROS generation and selective functional incapacity of NRF2-mediated antioxidant gene expression played a role in the defects in mtDNA replication and unfitness of mtDNA for replication and gene expression in Chagas disease.Fil: Wan, Xianxiu. University of Texas Medical Branch; Estados UnidosFil: Gupta, Shivali. University of Texas Medical Branch; Estados UnidosFil: Zago, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaFil: Davidson, Mercy M.. Columbia University; Estados UnidosFil: Dousset, Pierre. Hospital San Bernardo; ArgentinaFil: Amoroso, Alejandro. Hospital San Bernardo; ArgentinaFil: Garg, Nisha Jain. University of Texas Medical Branch; Estados Unido
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