531 research outputs found
Comorbidities contribute to the risk of cancer death among Aboriginal and non-Aboriginal South Australians: analysis of a matched cohort study
No full textData source: Supplementary data, https://doi.org/10.1016/j.canep.2017.12.005Abstract not availableDavid Banham, David Roder, Alex Brown (for the CanDAD Aboriginal Community Reference Group and other CanDAD investigators
Nouvelle topographie des Alpes, montagnes de neige et de glace, chemins sur des montagnes, sources etc. de la Suisse
No full text[David Herrliberger] ; [Text von Daniel Roder]Kupfertitel und Frontispi
Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy
No full textWe report single-molecule measurements on the folding and unfolding conformational equilibrium distributions and dynamics of a disulfide crosslinked version of the two-stranded coiled coil from GCN4. The peptide has a fluorescent donor and acceptor at the N termini of its two chains and a Cys disulfide near its C terminus. Thus, folding brings the two N termini of the two chains close together, resulting in an enhancement of fluorescent resonant energy transfer. End-to-end distance distributions have thus been characterized under conditions where the peptide is nearly fully folded (0 M urea), unfolded (7.4 M urea), and in dynamic exchange between folded and unfolded states (3.0 M urea). The distributions have been compared for the peptide freely diffusing in solution and deposited onto aminopropyl silanized glass. As the urea concentration is increased, the mean end-to-end distance shifts to longer distances both in free solution and on the modified surface. The widths of these distributions indicate that the molecules are undergoing millisecond conformational fluctuations. Under all three conditions, these fluctuations gave nonexponential correlations on 1- to 100-ms time scale. A component of the correlation decay that was sensitive to the concentration of urea corresponded to that measured by bulk relaxation kinetics. Thetrajectories provided effective intramolecular diffusion coefficients as a function of the end-to-end distances for the folded and unfolded states. Single-molecule folding studies provide information concerning the distributions of conformational states in the folded, unfolded, and dynamically interconverting states.Author manuscript. Published in final edited form as: Proc Natl Acad Sci U S A. 2000 November 21; 97(24): 13021-13026.The final published version of this article is located at: http://www.pnas.org/cgi/reprint/97/24/13021NIH GM54616; to William F. DeGradoNIH GM12592; to Robin M. HochstrasserNIH GM48130; to William F. Degrado and Robin M. HochstrasserThis work was supported by GM54616 (to W.F.D.), GM12592 (to R.M.H.) and GM48130 (to W.F.D. and R.M.H.) with instrumentation developed under RR01348. D.S.T. was supported by National Institutes of Health Grant NRSA F32-GM18589.Also available in PubMed Central. PMCID:PMC2717
Do the benefits of screening mammography outweigh the harms of overdiagnosis and unnecessary treatment?
No full textYes. Public health adviser David Roder and Cancer Council Australia CEO Ian Olver believe the reduction in breast cancer mortality in Australia reflects both treatment and screening effects
Does exclusion of cancers registered only from death-certificate information diminish socio-demographic disparities in recorded survival?
No full textAbstract not availableHanna E. Tervonen, David Roder, Stephen Morrell, Hui You, David C. Curro
Differences in impact of Aboriginal and Torres Strait Islander status on cancer stage and survival by level of socio-economic disadvantage and remoteness of residence-A population-based cohort study in Australia
No full textAbstract not availableHanna E. Tervonen, Sanchia Aranda, David Roder, Richard Walton, Deborah Baker, Hui You, David Curro
Socio-demographic disadvantage and distant summary stage of cancer at diagnosis-A population-based study in New South Wales
No full textAbstract not availableHanna E. Tervonen, Richard Walton, David Roder, Hui You, Stephen Morrell, Deborah Baker, Sanchia Arand
Disparities in cancer stage at diagnosis and survival of Aboriginal and non-Aboriginal South Australians
No full textData source: Supplementary data, http://www.sciencedirect.com/science/MiamiMultiMediaURL/1-s2.0-S1877782117300590/1-s2.0-S1877782117300590-mmc1.docx/277953/html/S1877782117300590/f04af5626552e7f327193492ef88fcc4/mmc1.docxAbstract not availableDavid Banham, David Roder, Dorothy Keefe, Gelareh Farshid, Marion Eckert, Margaret Cargo, Alex Brown, for the CanDAD Aboriginal Community Reference Group and other CanDAD investigator
Metastatic colorectal cancer in young adults: a study from the South Australian Population-Based Registry
No full textAbstract not availableSina Vatandoust, Timothy J. Price, Shahid Ullah, Amitesh C. Roy, Carole Beeke, Joanne P. Young, Amanda Townsend, Robert Padbury, David Roder, Christos S. Karapeti
Development of Indicators to Assess Quality of Care for Prostate Cancer
No full textAbstract not availableNupur Nag, Jeremy Millar, Ian D. Davis, Shaun Costello, James B. Duthie, Stephen Mark, Warick Delprado, David Smith, David Pryor, David Galvin, Frank Sullivan, Aine C. Murphy, David Roder, Hany Elsaleh, David Currow, Craig White, Marketa Skala, Kim L. Moretti, Tony Walker, Paolo De Ieso, Andrew Brooks, Peter Heathcote, Mark Frydenberg, Jeffery Thavaseelan, Sue M. Evan
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