54,729 research outputs found
q-Differential equations for q-classical polynomials and q-Jacobi-Stirling numbers
No full textWe introduce, characterise and provide a combinatorial interpretation for the so-called q-Jacobi–Stirling numbers.
This study is motivated by their key role in the (reciprocal) expansion of any power of a second order
q-differential operator having the q-classical polynomials as eigenfunctions in terms of other even order operators,
which we explicitly construct in this work. The results here obtained can be viewed as the q-version of
those given by Everitt et al. and by the first author, whilst the combinatorics of this new set of numbers is a
q-version of the Jacobi–Stirling numbers given by Gelineau and the second author
Tobin's Q and Financial Policy
No full textRecent research in macroeconomics has emphasized the importance of linking the financial and real sectors and the need for working with optimizing models. Tobin’s Q model of investment would appear to provide a framework that can satisfy these two criteria. In contrast to the original presentation of the Q model, the formal development has not recognized that the firm actively participates in a number of financial markets; in this broader context, we show that Q is likely to be an uninformative and possibly misleading signal for investment expenditures . We then endeavor to turn this negative theoretical result to positive advantage in resolving a number of empirical problems with Q models, but the modifications dictated by the theory receive little support from the data.
Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet
No full textQuercetin, a polyphenolic compound and a major bioflavonoid in the human diet, has anti-inflammatory properties and has been postulated to enhance energy expenditure (EE). We sought to determine whether quercetin alters body weight, body composition, EE, and circulating markers of inflammation. At 6 weeks (W) of age, 2 cohorts of C57BL/6J mice (N = 80) were placed on one of 2 diets for 3W or 8W: (1) high fat (HF) (45% kcal fat) or (2) high fat + quercetin (HF + Q) (45% kcal fat + 0.8% quercetin). Quercetin concentrations in the diet and plasma were evaluated using mass spectrometry. Body weight, composition (nuclear magnetic resonance), and food consumption were measured weekly. Energy expenditure was measured by indirect calorimetry at 3 and 8W, and inflammatory markers were measured in plasma obtained at 8W. The presence of quercetin in the HF diet did not alter food consumption over time in the HF + Q group and did not differ from the HF group at any time point. However, circulating plasma quercetin concentrations declined between 3 and 8W. At 3W, EE was higher during both day and night phases (P <.0001) in the HF + Q group compared with the HF group; but this difference was not detected at 8W and did not translate into significant differences between the HF + Q and HF groups with respect to body weight or body composition. During the night phase, concentrations of the inflammatory markers (interferon-γ, interleukin-1α, and interleukin-4) were significantly lower when compared with HF treatment group (P <.05). Dietary supplementation with quercetin produces transient (3W) increases in EE that are not detected after 8W on the diet. A corresponding decrease in circulating quercetin between 3 and 8W suggests that metabolic adaptation may have diminished the impact of quercetin's early effect on EE and diminished its overall effect on nutrient partitioning and adiposity. However, quercetin at the levels provided was effective in reducing circulating markers of inflammation observed in animals on an HF diet at 8W.This work was supported by the National Center for Complementary and Alternative Medicine (NCCAM) and the Office of Dietary Supplements (ODS) (NIH Grant P50AT002776-01), and by support from NIH CNRU P30 DK072476 and P20 RR021945 (TWG).NIH P50 AT002776-01; by William CefaluNIH CNRU P30 DK072476NIH P20 RR021945; by Thomas W. GettysThe published version of this article is available at: http://www.metabolismjournal.com
Stewart, David Q M S, 6415
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/419271Surname: STEWarT. Given Name(s) or Initials: DAVID Q M S. Military Service Number or Last Known Location: 6415. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 13353.243757
Item: [2016.0049.51532] "Stewart, David Q M S, 6415
Regulation Q and the behavior of savings and small time deposits at commercial banks and thrift institutions
No full textAn abstract for this article is not availableBanks and banking ; Regulation Q: Prohibition Against Payment of Interest on Demand Deposits
DILL 2012 Summer School - Q&A session after the Lecture in Florence by R. David Lankes
No full textDILL 2012 Summer School - Q&A session after the Lecture in Florence by R. David Lankes Pag
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Network Q
No full textA press release from Network Q announcing that they will begin featuring Brian McNaught, a gay columnist and author, for a monthly segment
Network Q
No full textA press release from Network Q announcing that they will begin featuring Brian McNaught, a gay columnist and author, for a monthly segment
Determinantes genéticos da infeção na febre Q crónica
No full textMestrado em Tecnologias Moleculares em SaúdeA febre Q é uma zoonose de distribuição mundial causada pela bactéria Coxiella burnetii. A doença, que resulta numa elevada morbilidade e mortalidade, pode manifestar-se na forma aguda autolimitada ou na forma crónica de evolução grave. Considera-se que uma resposta imunitária deficitária poderá contribuir para o desenvolvimento da febre Q crónica. O presente estudo procurou identificar, na população portuguesa, variantes genéticas dos principais genes envolvidos na resposta imune à infeção que pudessem estar associadas a um desenvolvimento de febre Q crónica. Recorremos à análise retrospetiva caso-controlo usando métodos de associação genótipo-fenótipo com base em genes candidatos (Candidate gene association studies - CGAS) através de um estudo exploratório e de um estudo réplica. No primeiro, utilizamos o NGS para sequenciar regiões codificantes e não codificantes nos genes IL12RB1, IFNGR1, IFNGR2, NRAMP1, TLR1, TLR2 e TIMP1. No segundo, foram genotipados, por sequenciação Sanger, variantes nos genes P2X7R e IFNG. As amostras incluíam 17 casos com doença cronica, 43 com doença aguda e 34 amostras de conveniência (saudáveis). SNPs com significância estatística resistindo à correção de Bonferroni foram identificados apenas no gene IFNGR2. A análise dos padrões de desequilíbrio de ligação revelou ainda outras variantes em associação. Concluindo, a estratégia adotada revelou-se adequada para a identificação de
determinantes genéticos da infeção na febre Q crónica. Contudo, será imprescindível avançar com estudos funcionais de modo a esclarecer o papel das variantes associadas com a febre Q crónica.ABSTRACT - Q fever is a zoonosis of worldwide distribution caused by the bacterium Coxiella burnetii. The disease, resulting in high morbidity and mortality, presents itself in the self-limiting acute form or in the chronic form, with severe implications. A defective immune response may contribute to the development of chronic Q fever. The present study aimed to identify, in the Portuguese population, genetic variants in the principal genes of the immune response to infection that could be associated with the development of chronic Q fever. A retrospective case-control candidate gene association study (CGAS) was used for genotype-phenotype association analysis in an exploratory study and in a replication study. In the first, we used NGS to sequence coding and non-coding regions in the IL12RB1, IFNGR1, IFNGR2, NRAMP1, TLR1, TLR2, and TIMP1 genes. In the second, the genes P2X7R and IFNG were genotyped using Sanger sequencing. The study sample included 17 chronic disease cases, 43 acute cases, and 34 convenient samples (healthy). SNPs with statistical significance resisting the Bonferroni correction were identified only in the IFNGR2 gene. Linkage disequilibrium analysis revealed other variants in the association. In conclusion, our strategy was found to be suitable for the identification of genetic determinants of infection in chronic Q fever. However, functional studies are necessary
in order to elucidate the role of the associated variants with chronic Q fever.N/
A Q Methodological Study of the Support Valued by Students with English as an Additional Language
No full textThis study investigated the viewpoints of students with English as an Additional Language (EAL). Specifically, I used Q methodology to highlight some of the viewpoints of learners with EAL on the strategies used by adults to support them in school. A Q set of 46 statements was produced, with each statement describing a strategy for supporting learners with EAL. The Q set was developed firstly through the use of two focus groups involving 11 students aged between 9 and 15, secondly through consultation with relevant professionals, and thirdly through a literature review. I then asked 30 participants aged between 9 and 18 to express their viewpoint through a Q sort exercise, by ranking strategies according to helpfulness. Factor analysis was used to identify viewpoints which were common to a group of participants. In the results section I present each of the emerging viewpoints as a Q sort arrangement, and also as a written description produced by interpreting the factor analysis results. The four viewpoints which emerge are discussed, along with the implications for professionals needing to provide personalised support, and also stay in touch with the viewpoints of individual students with EAL in school. It is hoped that the current research will address the need within the literature to include the voice of students with EAL in planning for their education
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