1,769 research outputs found
La Cholla Boulevard : Magee Road
No full textabstract: The Pima County Department of Transportation in cooperation with the Town of Oro Valley and the Regional Transportation Authority proposes to widen approximately 5 miles of La Cholla Boulevard from a two-lane arterial roadway into a four-lane divided arterial roadway between Magee Road and Tangerine Road. During Phase 1 of the proposed project, PCDOT will lead the preliminary roadway design for the entire corridor and will design and construct the roadway improvements from
Magee Road to Lambert Lane. During Phase 2, the Town of Oro Valley will complete the design and construct the roadway improvements from Lambert Lane to Tangerine Road
The identity of the type of Tanacetum burchellii DC. (Asteraceae, Anthemideae), and the correct author citation for Pentzia punctata Harv. ex Hutch.
No full textAbstractThe identity of the type of Tanacetum burchellii DC. is re-assessed. The original material cited by Augustin P. de Candolle represents two different species. When compared to the protologue, it is clear that only one of the two specimens fits the description and is therefore here designated as lectotype. However, the selected lectotype is clearly conspecific with Foveolina albidiformis (Thell.) Källersjö and as a result the new combination Foveolina burchellii (DC.) Magee is proposed as the correct name for this taxon. The correct author citations, typifications and synonyms for both Foveolina burchellii and Pentzia punctata Harv. ex Hutch. are provided
GRAPHICAL CONFIGURATION PROGRAMMING - THE STRUCTURAL DESCRIPTION, CONSTRUCTION AND EVOLUTION OF SOFTWARE SYSTEMS USING GRAPHICS
No full textPublished versio
Revealing mechanisms of metabolic pathways associated with cancer pain
No full textDysregulation of lipid metabolism is a hallmark of oncogenesis. Many lipid metabolites have been implicated in non-cancer pain states, but their role in cancer-related pain has yet to be firmly established. Previous work in our laboratory has shown that oncogenic mutations in PIK3CA trigger a multi-modal signalling network leading to elevated levels of arachidonic acid and a concomitant overproduction of prostaglandin E2 (PGE2), both of which have been demonstrated to play a significant role in non-cancer pain. A systematic review of the analgesic efficacy of non-steroidal anti-inflammatory drugs reveals that no studies to date have interrogated or identified any association between analgesic efficacy of these agents, with metabolic or genomic profiles of tumours. In the absence of any data linking these, a retrospective case-controlled study identified that oncogenic mutations in PIK3CA are observed with a greater frequency in patients who experience persistent post-surgical pain (PPSP) following breast cancer surgery, compared to matched controls without pain. Of those experiencing PPSP, PIK3CA mutations are associated with greater pain interference and psychological morbidity. With respect to exploring potential mechanisms, this thesis begins by replicating previous findings that elevated levels of arachidonic acid and PGE2 are observed in the context of oncogenic PIK3CA mutations. Subsequently, it is demonstrated that activation of the PI3K/AKT pathway also drives enhanced extracellular levels of another pain-related bio-active lipid - lysophosphatidic acid (LPA). Overproduction of LPA is demonstrated to have pro-tumourigenic effects; namely to stimulate cellular migration and cell proliferation beyond a cell-autonomous manner. Unlike with arachidonic acid, the elevated levels of LPA are observed both in the context of oncogenic PIK3CA and AKT mutations with AKT-mediated activation of PLD2 driving this observation
Business Papers (MS 80-0003)
No full textDeed of trust from W. T. Magee and Sallie Magee to William S. Eno for Bunnell & Eno Investment Co. conveying land part of the P. S. McNeal survey
Model Synthesis from Imprecise Specifications
No full textThe paper defines a formal semantics for MSC scenarios that is a weakening of the state semantics from [6], whilst permitting some additional semantics in the spirit of Live Sequence Charts (LSCs) [4]. The semantics here differs from that of LSCs in that mandatory behaviour is defined dynamically within the domain of possible scenarios. This permits a semantics which uses domain knowledge to define when compositions of imprecise requirements are valid. This has been implemented by Motorola UK Research Labs, and is being used in a pilot study for a new telecommunications mobile 3G handset
[Kay Bailey Hutchison and David Langston]
No full textUndated photograph of Senator Kay Bailey Hutchison and Mayor David Langston at an unidentified event
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