486 research outputs found
The Ironic Defense of Socrates
No full textThis book offers a controversial interpretation of Plato's Apology of Socrates. By paying unusually close attention to what Socrates indicates about the meaning and extent of his irony, David Leibowitz arrives at unconventional conclusions about Socrates' teaching on virtue, politics, and the gods; the significance of his famous turn from natural philosophy to political philosophy; and the purpose of his insolent 'defense speech'. Leibowitz shows that Socrates is not just a colorful and quirky figure from the distant past but an unrivaled guide to the good life - the thoughtful life - who is as relevant today as in ancient Athens. On the basis of his unconventional understanding of the dialogue as a whole, and of the Delphic oracle story in particular, Leibowitz shows that the Apology is the key to the Platonic corpus, indicating how many of the disparate themes and apparently contradictory conclusions of the other dialogues fit together.</jats:p
David Leibowitz, The Ironic Defense of Socrates. Plato’s Apology
No full textCet ouvrage est une analyse linéaire, attentive, patiente et fine de l’Apologie de Socrate écrite par Platon. En revendiquant l’influence des enseignements et écrits de Christopher Bruell et Leo Strauss, David Leibowitz vise à offrir une nouvelle interprétation non consensuelle d’un texte abondamment lu, expliqué et commenté. L’auteur pense apporter une nouvelle compréhension de l’Apologie (sans toutefois procéder lui-même à la traduction originale des extraits cités) grâce à une méthode qui ..
David Leibowitz, The Ironic Defense of Socrates. Plato’s Apology
No full textCet ouvrage est une analyse linéaire, attentive, patiente et fine de l’Apologie de Socrate écrite par Platon. En revendiquant l’influence des enseignements et écrits de Christopher Bruell et Leo Strauss, David Leibowitz vise à offrir une nouvelle interprétation non consensuelle d’un texte abondamment lu, expliqué et commenté. L’auteur pense apporter une nouvelle compréhension de l’Apologie (sans toutefois procéder lui-même à la traduction originale des extraits cités) grâce à une méthode qui ..
René Leibowitz
No full textRené Leibowitz (*17.02.1913, Warschau – 28.08.1972, Paris) war in seinen Tätigkeiten als Komponist, Dirigent, Musiktheoretiker, Pädagoge maßgeblich an der Verbreitung der Dodekaphonie nach dem Zweiten Weltkrieg in Europa beteiligt und übte dadurch entscheidenden Einfluss auf die dortige Entwicklung der Musikgeschichte des 20. Jahrhunderts aus. Seit 1925/26 in Paris ansässig, war Leibowitz aufgrund seiner jüdischen Herkunft gezwungen, zwischen den Jahren 1940 bis 1944 in Frankreich versteckt zu leben. Bestärkt durch dieses Schicksal engagierte er sich für die Komponisten der Zweiten Wiener Schule als Interpret und Verfasser musikwissenschaftlicher Schriften - im speziellen für Arnold Schönberg, Anton Webern und Alban Berg, aber auch für Komponisten aus deren Umkreis wie Edward Spinner, Erich Itor Kahn, Edward Steuermann, Artur Schnabel und viele mehr. Als Dirigent unternahm Leibowitz zahlreiche Aufnahmen, wie etwa die Gesamteinspielung der neun Beethoven-Symphonien. Leibowitz’ Intention war es, die in den Partituren niedergeschriebenen Angaben der Komponisten in höchstem Maße zu verwirklichen. Diesem Ziel blieb er bis zu seinem Lebensende treu. Das kompositorische Schaffen René Leibowitz’, das bislang nahezu unbekannt ist, umfasst 92 Werke aller musikalischen Gattungen - darunter 5 Opern.As composer, conductor, musicologist and pedagogue, René Leibowitz (*17.02.1913 Warsaw – 28.08.1972 Paris) has made immense contribution to the diffusion of the twelve-tone-technique (dodecaphony) throughout Europe after World War II; in that capacity, his influence over the development of 20th century music history is notable.
He lived in Paris since the age of thirteen (1925/26). However, his Jewish origins forced him to go underground between the periods 1940-1944. This bitter destiny, far from discouraging him, inspired him to devote a great part of his life to composers of the Second Viennese School. As an interpreter and author of musicological writings his particular focus was on the works of Arnold Schoenberg, Anton Webern and Alban Berg. Other musicians of interest were Edward Spinner, Erich Itor Kahn, Edward Steuermann, Artur Schnabel and many more. As conductor he has undertaken numerous recordings, prominent among which is the entire nine symphonies of Beethoven.
Leibowitz's most important goal in life is to faithfully interpret music as indicated in the composer's scores. Towards this goal, he remained true to the end of his life. His compositional oeuvres, unfortunately hardly known, include 92 works of various musical genres and 5 operas
Critical professionalism: a lecturer attribute for troubled times
No full textCITATION: Leibowitz, B. & Holgate, D. 2012. Critical professionalism: a lecturer attribute for troubled times, in B. Leibowitz (ed.). Higher Education for the Public Good: Views from the South. Stellenbosch: AFRICAN SUN MeDIA. 165-178. doi:10.18820/9781928357056/13.The original publication is available from AFRICAN SUNMeDIA - www.sun-e-shop.co.zaIntroduction: This chapter describes the research-based project, Critical Professionalism, which gave rise to several of the chapters in this volume. We suggest that the concept of critical professionalism, with its strong valueorientation, makes a foundational contribution to approaches to professional
development for teaching for the public good in South Africa and other parts of the world. We use data generated from this project to tease out some of the characteristics of critical professionals, as well as some of the key ingredients necessary to support the emergence of academics as critical professionals.
We begin by setting the scene for the study and explaining why, in the present era, academics’ sense of agency, criticality and professionalism might be threatened – to a fair degree by the rise of the audit culture and a strong managerial and prescriptive approach to steering the direction of higher education.Publishers' versio
Conversations with Jon Leibowitz and Joaquin Almunia
No full textCompetition authority leaders are assuming increasing responsibilities and wearing many hatsâ€â€not only as regulators but also as advocates of markets.
A will to write
No full textThis article is based on an interview conducted by Brenda Leibowitz with Ron Barnett, noted author of over 20 academic books and 100 articles, at the 2012 annual Higher Education Teaching and Learning Association of Southern Africa (HELTASA). The interview deals with topics including: the challenge of formulating and articulating a definite thesis, the importance of polishing and crafting drafts, keeping multiple audiences in mind, the different demands of writing articles and books, the value of poetry and fiction, how to keep going as a writer, issues of identity, and maintaining a will to write. The article continues with a set of joint critical reflections on the nature of academic writing and concludes with the suggestion that writing can enhance academics’ understanding of themselves
Method for raising hdl cholesterol levels
No full textCompounds which are PPAR delta agonists are described. These compounds are useful for raising high density lipoprotein (HDL) plasma levels in mammals and for preventing, halting or slowing the progression of atherosclerotic cardiovascular diseases and related conditions and disease events. PPAR delta agonists can be administered alone or in combination with additional active agents such as LDL-lowering agentsLISPApplicant(s): Merck & Co Inc [Us], Leibowitz Mark D, Berger Joel P, Moller David E, Auwerx Johan, Berger Gregory DAlternative title(s) :
(de) Heterocyclische verbindungen als antidiabetische mittel und für die behandlung von fettleibigkeit
(fr) Derives heterocycliques utilises comme agents contre le diabete et contre l'obesite
(en) Heterocyclic derivatives as antidiabetic and antiobesity agent
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David Hume and the Paradox of Taste
No full textDavid Hume’s resolution of the paradox of taste poses an interesting question for us to ponder. Rather than take a purely subjectivist or objectivist view of the topic, Hume strikes a balance between the two positions by upholding two of three statements regarding taste that are widely held to be true. Hume claims that only judgements of taste that are in accordance with the standard of taste are correct. The standard of taste is established by a joint verdict of acknowledged experts in the identification and evaluation of art.
I argue that Hume’s assertions about taste are problematic. The experts that Hume claims exist are not useful if they can not be independently verified or if their heightened acuity of perception is fundamentally different from the average persons. Through various analogies, I demonstrate the shortcomings of Hume’s experts. However, assuming that Hume’s experts exist, they may be deserving of our deference if they are able to use their heightened acuity of perception to expand the lay-person’s appreciation of works of art.
Previous literature has taken issue with Hume’s argument before. Both Isabel Hungerland and Peter Kivy have both objected on the grounds of the inability to independently verify the verdicts of the experts. Kivy, in particular, has gripes with the standard of taste as described by Hume’s proposal and is skeptical of deferring judgements to Hume’s proposed experts. In my essay, I propose an alternative use of the experts that circumvents these issues
Molecular regulation of insulin-like growth factor binding protein-3 and its role in ribotoxic stress-induced apoptosis
No full textInsulin-like growth factor binding protein-3 (IGFBP-3) is one of six high affinity binding proteins for IGF-I. However, new and exciting IGF-independent functions have begun to emerge for IGFBP-3 in the regulation of cell growth. Specifically, the biological role of IGFBP-3 in apoptosis has been found to be extremely complex, with a number of possible functions suggested, but few well-characterized mechanisms determined. The overall goal of this work was to elucidate the role of IGFBP-3 within the context of ribotoxic stress-induced apoptosis, with specific aims to determine how ribotoxic stressors regulate IGFBP-3 expression and how IGFBP-3 influences the apoptotic pathway. Studies involving both chemical inhibitors and siRNA determined that the ribotoxic stressors anisomycin (ANS) and ricin A chain (RTA) both induced IGFBP-3 expression through the p38 signaling pathway, and that both stressors enhanced IGFBP-3 mRNA stability through a 3'untranslated region-mediated, p38 dependent mechanism. Additional studies demonstrated that RTA also activated the IGFBP-3 promoter in a p38-dependent manner. Subsequent work allowed for the conclusion that IGFBP-3 is specifically required for ANS and RTA-induced apoptosis. Knockdown of IGFBP-3 with siRNA prevented ANS-induced cytochrome c release, caspase activation and PARP cleavage. Knockdown of JNK-2 also inhibited caspase activation and PARP cleavage, suggesting that it and IGFBP-3 were involved in the same apoptotic mechanism. These findings led to the discovery that the orphan nuclear receptor Nur77 translocated to the cytosol following ANS treatment, where it is known to induce apoptosis. Additionally, knockdown of either IGFBP-3 or JNK-2, pre-treatment with the nuclear export inhibitor leptomycin B (LMB) or treatment with IGF-I could both prevent this translocation and prevent ANS-induced apoptosis. In conclusion, this work describes the novel regulation of IGFBP-3 by the p38 pathway, and helps to shed light on the complex role that IGFBP-3 plays in apoptosis. These findings suggest that IGFBP-3 may be an integral part of the inherent apoptotic machinery in normal cells and may play a crucial role in the response of normal cells to toxic stressors.Ph.D.Includes bibliographical references (p. 138-165)
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