530 research outputs found
University of Maryland football team doctors, College Park, Maryland, circa 1991
No full textPhoto of University of Maryland team doctors, c. 1991. Back of photo reads: "L TO R: DR DAVID LINEHAN, DR STANFORD LAVINE, DR STEPHEN SANDLER, DR IRWIN ARDAM UNIVERSITY OF MARYLAND PHOTO BY: KATIE ZERNHELT
Flow-induced vasodilation in the ferret lung
No full text Chammas, Joseph H., David. A. Rickaby, Margarita Guarin, John H. Linehan, Christopher C. Hanger, and Christopher A. Dawson.Flow-induced vasodilation in the ferret lung. J. Appl. Physiol. 83(2): 495–502, 1997.—To examine the possibility that shear stress may be a pulmonary vasodilator stimulus, we studied the effect of changing blood flow on the diameters of small pulmonary arteries in isolated perfused ferret lung lobes. The arteries studied were in the ∼0.3- to 1.3-mm-diameter range, and the diameters were measured by using microfocal X-ray imaging. The diameters were measured at two flow rates, 10 and 40 ml/min, with the intravascular pressure in the measured vessels the same at the two flow rates as the result of venous pressure adjustment. The response to a change in flow was studied under both normoxic and hypoxic conditions. Hypoxia was used to elevate pulmonary arterial tone to increase the likelihood of detecting a vasodilator response. Under normoxic conditions, changing flow had little effect on the arterial diameters, but under hypoxic conditions the arteries were consistently larger at the higher flow than at the lower flow, even though the distending pressure was the same at the two flow rates. The results are consistent with the hypothesis that shear stress is a pulmonary vasodilator stimulus. </jats:p
Utah Law Review 2012 Number 1
No full textTABLE OF CONTENTS ARTICLES Law, Fact, and Discretion in the Federal Courts: An Empirical Study Robert Anderson IV 1 Bargained Justice: Plea-Bargaining\u27s Innocence Problem and the Brady Safety-Valve Lucian E. Dervan; Recantations Reconsidered: A New Framework for Righting Adam Heder & Wrongful Convictions Michael Goldsmith; Remedying the Misuse of Nature Sanne H. Knudsen; Due Process Denied: The Forgotten Constitutional Limits on Choice of Law in the Enforcement of Employee Covenants Not to Compete David A. Linehan; The Penguin and the Cartel: Rethinking Antitrust and Innovation Policy for the Age of Commercial Open Source Stephen M. Maurer; Class Action Defendants\u27 New Lochnerism Mark Moller; A Minimalist Approach to Same-Sex Divorce: Respecting States that Permit Same-Sex Marriages and States that Refuse to Recognize Them Robert E. Rains; The Common Law of Disability Discrimination Mark C. Weber; NOTES E-Verify During a Period of Economic Recovery and High Unemployment Emily Patten; Incentive for Innovation or Invitation to Inhumanity?: A Human Rights Analysis of Gene Patenting and the Case of Myriad Genetics Laurie E. Abbot
Estimation of the pulmonary capillary transport function in isolated rabbit lungs.
No full textRecently, we presented a method for estimating the pulmonary capillary volume and transport function based on the use of a reference indicator and two or more indicators that rapidly equilibrate (radially) with the tissue (i.e., the concentrations in the vascular and extravascular spaces at a given axial location are in equilibrium) during transit through the capillaries in a bolus-injection indicator dilution method (S. H. Audi, G. S. Krenz, J. H. Linehan, D. A. Rickaby, and C. A. Dawson. J. Appl. Physiol. 77: 332-351, 1994). The objectives of the present study were 1) to determine whether [14C]diazepam and [3H]alfentanil equilibrate sufficiently rapidly between the vascular space and tissue and with sufficiently different pulmonary extravascular mean residence times to be used in a single bolus to estimate the pulmonary capillary volume and transport function using this method and 2) to estimate the pulmonary capillary volume and transit time distribution in isolated perfused rabbit lungs. Both [14C]diazepam and [3H]alfentanil were found to be rapidly equilibrating indicators by the criteria that, over a wide range of flow rates, their respective venous effluent concentration curves were nearly congruent on a time scale normalized to the lung mean transit time for the reference indicator (fluorescein isothiocyanate dextran). In addition, at a given plasma albumin concentration, [14C]diazepam had a significantly longer extravascular mean residence time than [3H]alfentanil, e.g., at 6% plasma albumin concentration, the extravascular mean residence time of [14C]diazepam was more than twice that of [3H]alfentanil. On average, the estimated pulmonary capillary volume for a 2.7- kg rabbit was ~4.2 ml or ~44% of the total pulmonary vascular volume (9.5 ml). The relative dispersion of the pulmonary capillary transport function of the rabbit was ~90%
Extended lymphadenectomy in the surgery of pancreatic adenocarcinoma and its relation to quality improvement issues
No full textExperimental and finite element models of the contact parameters and temperature distributions in electrical injuries
No full textStudies were conducted to further an understanding of injuries due to contact with low voltage 60 Hz alternating currents. The impedance characteristics of circular and elliptical stainless steel electrodes, with areas of 0.3 to 20 cm\sp2 and circumferences of 2 to 28 cm, were analyzed in a saline tank. The saline tank resistance was inversely proportional to the product of electrode area to the one-quarter power and electrode circumference to the one-half power. To analyze the effects of contact geometry and duration on the cross-body resistance, which includes interface effects and body resistance, 100 volts was applied across the hindquarters of anesthetized hogs, between one of eight electrodes and a metal plate. The resulting current rose sharply to half the maximum, gradually reached the maximum, and then rapidly diminished to approximately zero. Average current durations varied from 24 to 326 seconds, and minimum cross-body resistances varied from 242 to 64 ohms, as the electrode size increased. Minimum cross-body resistance varied more with electrode circumference than area. To analyze the effects of contact voltage on the cross-body resistance, a voltage between 75 and 250 volts was applied across the hindquarters of anesthetized hogs, between a 2.5 cm diameter electrode and a metal plate. The voltage was applied until a cessation of current flow was observed. As the applied voltage increased from 75 to 250 volts, average current durations decreased from 225 to 4 seconds, and minimum cross-body resistances increased from 93 to 180 ohms. To measure the temperature distributions in an experimental electrical injury, thermistors were implanted prior to application of 100 volts across the hindquarters of anesthetized hogs between a 5.0 cm diameter electrode and a metal plate. Tissue temperatures were recorded every 10 seconds during the application and post-insult until all temperatures returned below 40\sp\circC. Temperatures in excess of 100\sp\circC were recorded beneath the edge of the electrode. Temperatures were significantly higher under the electrode edge than center. Two-dimensional axisymmetric finite element models of voltage and temperature distributions resulting from a disk in contact with a semi-infinite medium were developed in three stages: steady-state thermal, steady-state electrical, and transient thermoelectrical. (Abstract shortened with permission of author.
Erratum : The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma (Cell Reports (2018) 23(1) (313–326.e5) (S2211124718304364) (10.1016/j.celrep.2018.03.075))
No full text(Cell Reports 23, 313–326; April 3, 2018) In the originally published version of this article, the author list contained two errors. Specifically, David J. Kwiatkowski was misspelled as David J. Kwaitkowski, and William Y. Kim was inadvertently written as William T. Kim. Both names have been corrected online. The authors regret this error
Cowden syndrome - Diagnostic skin signs
No full textCowden syndrome is a rare autosomal dominant familial cancer syndrome with a high risk of breast cancer. The most important clinical features include carcinomas of the breast and thyroid, and hamartomatous polyps of the gastrointestinal tract. There are characteristic mucocutaneous features which allow early recognition of the disease and are generally present before internal malignancies develop. We report on a woman in whom the diagnosis of Cowden syndrome was first made after she had been treated for both breast cancer and melanoma. Copyright (C) 2001 S. KargerAG, Basel
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