1,721,310 research outputs found
David Baltimore, 1975
Full text linkDavid Baltimore. The strategy of RNA viruses
Lecture delivered January 16, 1975
Posted with permissionhttps://digitalcommons.rockefeller.edu/harvey-lectures/1049/thumbnail.jp
An interview with David Baltimore
No full textPresident of Caltech since 1997, Professor David Baltimore is best known for his Nobel Prize winning discovery of reverse transcriptase and the mechanisms that retroviruses use to infect cells. His work has greatly contributed to the understanding of cancer and AIDS, and his commitment to public policy has earned him numerous awards, including a 1999 National Medal of Science. He kindly agreed to talk to Gene Therapy
[An interview with...] David Baltimore
No full textDavid Baltimore was born in 1938. He attended Swarthmore College, Pennsylvania, as an undergraduate and obtained his Ph.D. from the Rockefeller Institute, New York, USA. He was a faculty member of the Salk Institute, California, and of the Massachusetts Institute of Technology (MIT) for many years. While at MIT, Baltimore received (at the age of 37) the Nobel Prize in Physiology or Medicine together with Howard Temin, for the discovery of reverse transcriptase. He was founding director of the Whitehead Institute, an academic affiliate of MIT. He has served as President of Rockefeller University and the California Institute of Technology (Caltech). He is currently President Emeritus and a professor at Caltech
QnAs with David Baltimore
Full text linkAt the age of 37, David Baltimore accomplished what many researchers dream of but few achieve: reversing an entrenched dogma, eventually leading to a new view of life. In the early 1970s, Baltimore, a member of the National Academy of Sciences and a professor of biology at the California Institute of Technology, discovered reverse transcriptase—an enzyme found in some tumor viruses whose genetic code is written in the RNA alphabet. He found that reverse transcriptase can copy RNA into DNA, indicating that some viruses replicate via a DNA intermediate. The finding, which won Baltimore and others the 1975 Nobel Prize in Physiology or Medicine, enriched biologists’ views on the direction of flow of genetic information in cells. Baltimore was the keynote speaker at the Sackler Colloquium, “Telomerase and Retrotransposons: Reverse Transcriptases That Shaped Genomes,” held in September 2010. Here, he offers PNAS readers his perspectives on reverse transcription
Science For Life: A Conversation With Nobel Laureate David Baltimore
No full textAs a man with equal interests in science and science policy, David Baltimore has been at the forefront of many of the important debates that have shaped science since the 1970s. Very much engaged in the initial discussions about the use of recombinant DNA technology, Baltimore had a front-row seat as the biotechnology industry developed. He was also a major player in the decision that resulted in funding of the Human Genome Project by the National Institutes of Health (NIH). Baltimore discusses biotechnology, science education, and the need for a strong dialogue among scientists and scholars in the health policy community
Interview with David Baltimore
Full text linkInterview in three sessions, October-November 2009, with David Baltimore, Robert Andrews Millikan Professor of Biology and president emeritus of Caltech (1997-2006).
He recalls his childhood and early education in Great Neck, NY, his aptitude for science, and a summer at the Jackson Laboratory in Maine (1955), which confirmed his vocation. He discusses interest in molecular biology at Swarthmore (B.A. 1960); 1959 summer at Cold Spring Harbor with G. Streisinger; meeting S. Luria and C. Levinthal; graduate work at MIT and Rockefeller (PhD 1964); 1961 summer at Albert Einstein College of Medicine; postdoc at MIT with J. Darnell and Einstein with J. Hurwitz. Recalls his discovery of polio polymerase and demonstration that RNA chains initiate with a triphosphate.
In 1965 he is invited to join Salk Institute by R. Dulbecco; returns to MIT as associate professor in 1968. Recalls his 1970 discovery of reverse transcriptase and copublication with H. Temin; 1975 Asilomar conference on recombinant DNA; 1975 Nobel Prize with Temin and Dulbecco; founding of Whitehead Institute for Biomedical Research; National Academy of Sciences committee on national strategy for AIDS. Comments briefly on investigation of T. Imanishi-Kari for fraud and his return to MIT from Rockefeller University in 1994.
He discusses vetting process for Caltech presidency, his 1998 inauguration, and highlights of his presidency, including purchase of St. Luke's Medical Center, $1.4 billion capital campaign, and building Broad Center for the Biological Sciences. Comments on Caltech architecture, including Cahill Center for Astronomy and Astrophysics; receiving National Medal of Science in 2000; L. Van Parijs dismissal from MIT and prior work in Baltimore's lab; and the prospects for human enhancement and understanding of consciousness
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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