1,543 research outputs found
La Cholla Boulevard : Magee Road
No full textabstract: The Pima County Department of Transportation in cooperation with the Town of Oro Valley and the Regional Transportation Authority proposes to widen approximately 5 miles of La Cholla Boulevard from a two-lane arterial roadway into a four-lane divided arterial roadway between Magee Road and Tangerine Road. During Phase 1 of the proposed project, PCDOT will lead the preliminary roadway design for the entire corridor and will design and construct the roadway improvements from
Magee Road to Lambert Lane. During Phase 2, the Town of Oro Valley will complete the design and construct the roadway improvements from Lambert Lane to Tangerine Road
The identity of the type of Tanacetum burchellii DC. (Asteraceae, Anthemideae), and the correct author citation for Pentzia punctata Harv. ex Hutch.
No full textAbstractThe identity of the type of Tanacetum burchellii DC. is re-assessed. The original material cited by Augustin P. de Candolle represents two different species. When compared to the protologue, it is clear that only one of the two specimens fits the description and is therefore here designated as lectotype. However, the selected lectotype is clearly conspecific with Foveolina albidiformis (Thell.) Källersjö and as a result the new combination Foveolina burchellii (DC.) Magee is proposed as the correct name for this taxon. The correct author citations, typifications and synonyms for both Foveolina burchellii and Pentzia punctata Harv. ex Hutch. are provided
Revealing mechanisms of metabolic pathways associated with cancer pain
No full textDysregulation of lipid metabolism is a hallmark of oncogenesis. Many lipid metabolites have been implicated in non-cancer pain states, but their role in cancer-related pain has yet to be firmly established. Previous work in our laboratory has shown that oncogenic mutations in PIK3CA trigger a multi-modal signalling network leading to elevated levels of arachidonic acid and a concomitant overproduction of prostaglandin E2 (PGE2), both of which have been demonstrated to play a significant role in non-cancer pain. A systematic review of the analgesic efficacy of non-steroidal anti-inflammatory drugs reveals that no studies to date have interrogated or identified any association between analgesic efficacy of these agents, with metabolic or genomic profiles of tumours. In the absence of any data linking these, a retrospective case-controlled study identified that oncogenic mutations in PIK3CA are observed with a greater frequency in patients who experience persistent post-surgical pain (PPSP) following breast cancer surgery, compared to matched controls without pain. Of those experiencing PPSP, PIK3CA mutations are associated with greater pain interference and psychological morbidity. With respect to exploring potential mechanisms, this thesis begins by replicating previous findings that elevated levels of arachidonic acid and PGE2 are observed in the context of oncogenic PIK3CA mutations. Subsequently, it is demonstrated that activation of the PI3K/AKT pathway also drives enhanced extracellular levels of another pain-related bio-active lipid - lysophosphatidic acid (LPA). Overproduction of LPA is demonstrated to have pro-tumourigenic effects; namely to stimulate cellular migration and cell proliferation beyond a cell-autonomous manner. Unlike with arachidonic acid, the elevated levels of LPA are observed both in the context of oncogenic PIK3CA and AKT mutations with AKT-mediated activation of PLD2 driving this observation
GRAPHICAL CONFIGURATION PROGRAMMING - THE STRUCTURAL DESCRIPTION, CONSTRUCTION AND EVOLUTION OF SOFTWARE SYSTEMS USING GRAPHICS
No full textPublished versio
Model Synthesis from Imprecise Specifications
No full textThe paper defines a formal semantics for MSC scenarios that is a weakening of the state semantics from [6], whilst permitting some additional semantics in the spirit of Live Sequence Charts (LSCs) [4]. The semantics here differs from that of LSCs in that mandatory behaviour is defined dynamically within the domain of possible scenarios. This permits a semantics which uses domain knowledge to define when compositions of imprecise requirements are valid. This has been implemented by Motorola UK Research Labs, and is being used in a pilot study for a new telecommunications mobile 3G handset
Analysis of Social Dynamics on FDA Panels Using Social Networks Extracted from Meeting Transcripts
No full textThe social elements of technical decision-making are not well understood, particular among expert committees. This is largely due to a lack of methodology for directly studying such interactions in real-world situations. This paper presents a method for the analysis of transcripts of expert committee meetings, with an eye towards understanding the process by which information is communicated in order to reach a decision. In particular, we focus on medical device advisory panels in the US Food and Drug Administration. The method is based upon natural language processing tools, and is designed to extract social networks from these transcripts, which are representative of the flow of information and communication on the panel. Application of this method to a set of 37 meetings from the FDA's Circulatory Systems Devices Panel shows the presence of numerous effects. Prominent among these is the propensity for panel members from similar medical specialties to use similar language. Furthermore, panel members who use similar language have the propensity to vote similarly. We find that these propensities are correlated - i.e., as panel members' language converges by medical specialty, panel members' votes also tend to converge. This suggests that voting behavior is mediated by membership in a medical specialty and supports the notion that voting outcome is, to some extent, dependent on an interpretation of the data associated with training.MIT-Portugal Progra
The Clay statue. A model of a man. Designed by the goddess of liberty
No full textThe artist lionizes Kentucky senator Henry Clay, author of the Compromise of 1850, and slams his political foes and critics of the compromise, particularly those in the Taylor administration. A text in the lower margin reads: "A Fable--In the Reign of Zackery 1st the Goddess of Liberty Designed a Statue. a Model of a Man which she exhibited before the King, his Ministers, & the People. the Beauty of the Statue Elicited such shouts of Approbation from the People that the King's Ministers fired with Jealousy determined to Destroy it, but after many Ineffectual attempts were obliged to Desist amidst the Laughter of the Court & the People." The King is clearly President Taylor, who sits on a throne at the far left, in uniform and holding a sword instead of a scepter. A spittoon is on the floor before him, and a black court jester crouches beside the throne holding a copy of the newspaper the "Republic." A larger-than-life statue of Henry Clay, in armor and holding a shield inscribed "Compromise" and a sword, stands in the center of the scene. Clay's sword bears the words, "I fight for my Country! Traitors Beware." The statue towers over the figures that surround it, which include Taylor cabinet members Reverdy Johnson, George W. Crawford, and Thomas Ewing (on the right) and Secretary of State John M. Clayton (on the left). Crawford and Ewing regard the broken ax and saw which they hold in their hands. Crawford (to Johnson): "Look here Just see what a great Big Piece Ive Broke of my Gulpin Ax. I'll send in a Gulpin Claim for this. Valuable Ax this." The allusion is to Crawford's lucrative and questionable role as counsel for the Galphin family's successful suit against the federal government, an arrangement which provoked heated criticism in the press. The controversy over this Taylor administration scandal reached its peak in April, May and June of 1850. Johnson: "The Ax, was Broke before you used it, however, you Lie & I'll Swear to it, & we'll Pockett the Plunder between us." Ewing: "Why Ive Broke nearly all the teeth of my Chickensaw against this Infernall Statue. I'le send in a Big Claim for this." Clayton gestures entreatingly to Taylor: "Why the Devil dont your Imperial Majesty assist us, I can assure your Majesty, it's much Easier discharging a Bullitt, from a Republic, than it is injuring this Statue." Journalist Alexander C. Bullitt was a Taylor advisor and, beginning in 1849, editor of the administration organ the Washington "Republic." Bullitt appears here as the black court fool. Taylor hugs to his chest the tiny figure of New York senator William H. Seward, who sits on his lap. Seward was an insider in the short-lived Taylor administration, and a vigorous opponent of the Compromise of 1850. Taylor says, "Consider the weight of my Crown, Dear Clayton. besides my sick Baby, little Billey, requires, all my Care. moreove as the People like the Statue, I'de rather not Compromise myself, in the matter. assume the Responsibility Yourself, you'r used to it." Just to the right of the throne stand (left to right) senators Thomas Hart Benton, Daniel Webster, and Henry S. Foote. Benton: "Why its a Miserable Statue. a wretched abortion, the inscriptions on the Sword & Shield are in very Bad Taste, very Bad Taste indeed." Benton was an adamant critic of the Compromise. Foote (to Webster): "I think its a Splendid Statue. Which Party do you go for." Webster: "The Party thats likely to win. Of Course, I shall Keep one eye on the Statue, & the other on the Chair, & act according to circumstances." Senator Lewis Cass stands to the right of Foote, in the background, saying, "I rather like the Inscription on the Shield." Clay does, however, have some friends here. On the far right is a crowd of people led by the figure of Liberty, a young maiden in a classical gown holding a staff and liberty cap. She addresses Johnson and the others, "Gentlemen! I made this Statue as a Model of a Man. now though it is only of Clay & I wafted it here in a Breath, still with all your efforts, you can neither move it from its Base, or inflict the slightest Injury upon it. its innate strenght [sic] will defy all your Puny attempts." Liberty's followers enjoin, "Why I think it's a Beautifull Statue," and "So do I! Hurrah! for the Clay Statue." "The Clay Statue," though tentatively dated 1849 by Weitenkampf, must have appeared in 1850, certainly after Henry Clay's presentation of the compromise in January and probably as late as the spring, at the height of the Galphin controversy.Drawn by John L. Magee.Pubd. by John L. Magee 34 Mott St. N.Y.Title appears as it is written on the item.Weitenkampf, p. 98.Forms part of: American cartoon print filing series (Library of Congress)Published in: American political prints, 1766-1876 / Bernard F. Reilly. Boston : G.K. Hall, 1991, entry 1850-9
Letter from Freddie Magee to John Muir, 1913 May 7.
No full text3our thoughts and memories. And for the object lessons in the pure love of nature & for the previous things of the lasting hills that you have, & you first & foremost, made the priceless possession of everyone that has eyes to see and hear to love & understand-none of us can be thankful enough to God & to you for interpreting his voice & his handiwork to us- How precious also are thy thoughts unto me, oh God! How great is the sum of them! Your life so well exemplies the2described The Bible that I prize so much as yours in my library-because of the intense personality of the author & because of the affection & sincerest esteem in which we Magees-girls & boys hold him. I especially feel a nearness to you by reason of that babyhood meeting in the Yosemite of you & my dear Mother & father in May 1871 & I do so prize the picture of my mother with me in her lap & I could only wish that you & my father were in the picture as you shall always be inhttps://scholarlycommons.pacific.edu/jmcl/42570/thumbnail.jp
Effects of experimental fascioliasis on puberty and comparison of mounting activity by radiotelemetry in pubertal and gestating beef heifers
No full textAngus-sired heifers were allotted by age (mean=4 mo), BW (mean=135 kg), and sire (n=4) to either a control (n=10) or infected group (n=11; 600 metacercariae of Fasciola hepatica, intraruminally) to test our hypothesis that puberty is delayed by experimental fascioliasis. Blood samples were collected biweekly for analysis of steroid hormone concentrations. At 2-wk intervals, BW was recorded, and samples were collected for analysis of liver enzymes and serum proteins and fecal egg counts. A radiotelemetry system (HeatWatch??) was used to detect estrus and ovulation was confirmed by an elevation in serum progesterone (P4) after estrus. Heifers were artificially inseminated (AI) at the second observed estrus. Serum γ-glutamyl transpeptidase (GGT) and aspartate aminotransferase (AST) increased (p0.1) between treatment groups. Mean age at puberty was 10 days later (p>0.1) in the infected group. Conception rate did not differ between control and infected heifers.
The HeatWatch?? data were used to compare mounting activity during estrus in pubertal and gestating heifers. Mean duration of estrus was longer (p<0.01) for the second than for the pubertal estrus, though total mount duration and number of mounts did not differ. Number of mounts at second estrus was greater (p<0.05) for heifers that conceived (n=9). Mean duration of estrus and total mount duration at second estrus were not associated with pregnancy outcome. Estrus events were detected in all nine heifers during pregnancy (total=73). A majority (75%) of the interestrus intervals during gestation was <17 d. Number of mounts (p=0.035) and total duration of mounts (p=0.022) at second estrus were predictive of number of mounts during gestation.
Experimental infection of Fasciola hepatica did not alter serum steroid hormone concentration or delay pubertal development in heifers. Estrus duration was longer for the second estrus compared to the pubertal estrus, and the number of mounts received during the second estrus was greater in heifers that did conceive to AI. Estrus events were detected in each heifer during pregnancy; however, a normal interestrus interval occurred in only 10% of the estrus events
What a Girl Wants, What a Girl Needs: Opening a Women's Centre in Castlegar
No full textWe have collaborated with staff and local women to perform a needs assessment for a women's centre in Castlegar. This will inform its development and ensure that we provide a safe, supportive environment for all women
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