1,720,957 research outputs found
The Role of the Matrix Metalloproteinase-9 Gene in Tumor Development and Metastasis: A Narrative Review
No full textMatrix metalloproteinase-9 (MMP-9) is one of the widely studied enzymes of the extracellular matrix which can degrade various matrix biomolecules. The gene coding for this enzyme has been found to be associated with various multifactorial diseases, including cancer. More specifically, the expression of MMP-9 and polymorphisms of its gene have been found to be correlated with the formation and the invasiveness of different types of cancer. Hence, the latter gene can potentially be used both as a clinical genetic marker and a possible target in anticancer therapy. The present minireview explores the role of the MMP-9 gene in the process of tumor formation, growth, and metastasis and presents an overview of the polymorphisms of the gene associated with cancer as well as its regulation mechanisms, to provide an insight into the potential clinical applications. Nevertheless, further clinical trials and research are still required to reach more valuable conclusions for the clinical implications of the recent findings
The emerging role of PET/CT scanning in the treatment planning of ovarian cancer: A mini-review
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The association between Fusobacterium nucleatum levels and chemoresistance in colorectal cancer: a systematic review
No full textINTRODUCTION: The lack of response to chemotherapeutic drugs is one of the major challenges faced in the treatment of colorectal cancer. Several studies have indicated that the microbiome of the bowel affects the treatment response and specifically, certain bacterial species contribute to the development of chemoresistance. With Fusobacterium nucleatum being one of the bacterial species frequently found in the bowel of colorectal cancer patients, the present systematic review was undertaken to gather the existing literature on the relationship of Fusobacterium nucleatum with chemotherapy response. METHODS: Major online academic databases were searched using a combination of keywords and Boolean operators, in order to retrieve literature on the topic from inception until February 2023. Observational studies with relevant information were included in the present systematic review and their quality was assessed. RESULTS: A total of 7 studies with 2280 colorectal cancer patients who underwent adjuvant or palliative chemotherapy were included in the qualitative synthesis. No study with a major risk of bias was found after quality assesment. The majority of studies observed poorer prognosis in patients who had high levels of Fusobacterium nucleatum in their bowel, although due to the small number of studies a meta-analysis could not be performed. CONCLUSIONS: High levels of Fusobacterium nucleatum result in lower response to chemotherapy in colorectal cancer. Nevertheless, to further verify this assertation, more observational and experimental studies must be undertaken in the clinical field
The connection between Fusobacterium nucleatum levels and chemoresistance in colorectal cancer – a systematic review
Full text linkIntroduction.The lack of response to chemotherapeutic drugs is one of the major challenges faced in the treatment of colorectal cancer. Several studies have indicated that the microbiome of the bowel affects the treatment response and specifically, certain bacterial species contribute to the development of chemoresistance. With Fusobacterium nucleatum being one of the bacterial species frequently found in the bowel of colorectal cancer patients, the present systematic review was undertaken to gather the existing literature on the relationship of Fusobacterium nucleatum with chemotherapy response. Material and methods.Major online academic databases were searched using a combination of keywords and Boolean operators, in order to retrieve literature on the topic from inception until February 2023. Observational studies with relevant information were included in the present systematic review and their quality was assessed. Results.A total of 7 studies with 2,280 colorectal cancer patients who underwent adjuvant or palliative chemotherapy were included in the qualitative synthesis. No study with a major risk of bias was found after a quality assessment. The majority of studies observed poorer prognosis in patients who had high levels of Fusobacterium nucleatum in their bowel, although, due to the small number of studies, a meta-analysis could not be performed. Conclusions.High levels of Fusobacterium nucleatum result in a poorer response to chemotherapy in colorectal cancer. Nevertheless, to further verify this assertation, more observational and experimental studies must be undertaken in the clinical field
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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