24 research outputs found
Application of Empirical Orthogonal Function Models to Analyze Shoreline Change at Bangkalan Madura
Get PDFBangkalan’s shoreline, especially on the opposite side of Surabaya, has been evaluated to determine the morphological changes due to wave attack, near-shore current, long-shore sediment transport and coastal configuration. This research aims to determine the dominant patterns of variation of Bangkalan’s shoreline change, expressed by Eigen-function in empirical orthogonal function (EOF) models. That was started with data collection such as oceanographic data (wave and tidal), bathymetry and topographic map and sediment data. All data was used for forecasting two-monthly shoreline. Coordinate of two-monthly shoreline was used as input of EOF model. The first Eigen mode is a profile of shoreline equilibrium. The second Eigen mode shows pivot point that separates the different behaviors, which indicates a positive balance of shoreline from the direction of the dominant force. The models execution based on 1986’s shoreline show the shoreline change significantly at some cells e.g. around Suramadu bridge (cell 1-40), Batuporon (cell 70-100), Jungdima (cell 142-170) and at Kamal port (cell 230-250). The model of shoreline change using EOF was validated with the One-line model and data of 1995’s map’s shoreline. The E.O.F. value of model RMSE, 0.02, is less than the root mean square error (RMSE) value of One-line model, 0.04, which shows that the EOF model performance better than One-line models
Discourse, Narrative and Agency: A Contribution of Local Stories to Disability Theory, Research and Professional Practice
No full textThe impetus for this study arose from a realisation that the post-structural concept of agency was relevant to disability studies. In locating this study as a contribution to the knowledge of disability and disablement, the initial chapters explore the theoretical genealogy of disability studies and the methodology for the study. In broad terms this has been a discursive and narrative research project, which sought to explore how discourse constituted the lives of six people with impairments and/or illness. Within this examination, specific attention was paid to those occasions in which the participants were able to take up alternative and preferred subject positions when they had been positioned in ways that removed or reduced their agency on account of their having an impairment and/or illness. The six people who participated in the study are introduced at the end of Chapter Four and the next three chapters provide an account of their accounts. Overall, the participants’ accounts of their experiences told how medical discourse positioned them in ways that removed their agency but not exclusively so. In contrast to medical discourse, disability rights discourses offered alternative subject positions because disablement is not constructed as an inevitable consequence of having an impairment and/or illness. In regard to the benefit of disability rights discourses for disabled people, two of the participants had been advantaged by the career opportunities available to them within the disability sector that arguably had been created by disability rights discourses. However, generally speaking, the participants’ accounts of their experiences showed that disability rights discourses were not the only discursive option for them. On those occasions in which the participants took up subject positions that afforded them agency, they were often calling on more than one discursive idea or practice, typically beyond both medical or disability rights discourse. The participants’ lives were more diverse and complex than the reproduction of any one singular discourse. Hence, even between just six people’s accounts, there was significant difference between how each person called on and negotiated discourse so as to take up subject positions that offered them agency. In considering the participants’ accounts, a number of generic storylines have been generated from the research process. In particular, these were: the negative impact of deficit discourse on disabled people’s lives, the advantages and limitations of disability rights discourses, the complex and person-specific processes of taking up subject positions that afford agency for the person, and the experience of silenced, subjugated and contradictory subject positions. These quite specific understandings about the processes of disablement for people who have impairments and/or illnesses, and their corresponding actions of agency, are discussed in more detail in the concluding chapter in regards to implications for future research, theory and professional practice
The use of fibre optic sensing technology with intraluminal impedance catheter for functional gastrointestinal motility disorders
No full textAuthor accepted manuscript made available with permission from Engineers Australia.We present a composite impedance fibre optic manometry catheter for monitoring functional gastrointestinal disorders (FGID). The catheter uses a dual lumen silicone extrusion to separate each technology and has been validated in ex-vivo animal models
Blinded side-to-side comparison of topical corticosteroid and tacrolimus ointment in children with moderate to severe atopic dermatitis
No full textThere is little information on the relative efficacy of topical tacrolimus and corticosteroids in the treatment of atopic dermatitis (AD) in children. In a single-centre, prospective, observer-blinded, side-to-side comparative study (ISRCTN65507338), 96 children with moderately severe AD were enrolled. The study aimed to compare the relative effectiveness of the child's usual topical corticosteroid with 0.03% tacrolimus ointment applied for 1 week, and if there was no difference, 0.1% tacrolimus ointment applied for a further week. Topical tacrolimus was found to be more effective than topical corticosteroid in 72 of the 93 children (77%) who completed the study. Using multiple-regression analysis with age, gender, pretreatment surface area affected and pretreatment corticosteroid potency as covariants, the only factor that reduced the chance of observing a beneficial effect with tacrolimus was moderate or potent topical corticosteroid use (OR = 0.13; 95% CI 0.02-0.74). © 2007 The Author(s)
Clinical variability and characteristic autoantibody profile in primary C1q complement deficiency
No full textObjectives. C1q deficiency is a rare inherited defect in the early part of the complement cascade. In this report, we describe the varied clinical features of patients with this condition as well as the characteristic autoantibody profile. Methods. A large Pakistani family with a high degree of consanguinity is described in which the father and five sons have C1q deficiency, all with different clinical manifestations. Results. Clinical features of C1q deficiency can vary from almost no disease to fulminant bacterial infection and localized lupus-like skin, renal or CNS disease. Autoantibodies to ribonucleoproteins such as anti-Sm and Ro, but not dsDNA, were present. Conclusions. Awareness of the spectrum of clinical disease, autoantibody profiles and tests required to confirm the diagnosis of C1q deficiency are important if this life-threatening immunodeficiency disease is to be managed correctly. © The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved
In-pipe fibre optic pressure sensor array for hydraulic transient measurement with application to leak detection
Get PDF© 2018 Elsevier BV. This manuscript version is made available under the CC-BY-NC-ND 4.0 license:
http://creativecommons.org/licenses/by-nc-nd/4.0/
This author accepted manuscript is made available following 24 month embargo from date of publication (May 2018) in accordance with the publisher’s archiving policy.Controlled hydraulic transient pressure waves can be used to actively assess the condition of
pressurised pipelines (e.g. leak detection). One practical challenge to the application of the
technique to buried water pipelines is in the pressure measurement – fast-response pressure
transducers are costly and the deployment is limited to one sensor per access point (e.g. at air
valves or fire hydrants). The measurement from a single sensor is always the superposition of
the waves travelling upstream and downstream along a pipe. It is often difficult to determine
the direction of the propagating waves, unless there are suitable locations nearby where
additional measurements can be made. The research reported here develops a fibre optic
pressure sensor array for in-pipe transient pressure measurement. The sensor array consists of
five Fibre Bragg Gratings (FBGs), each formed into a custom designed pressure transducer.
The cable containing the array has a diameter of approximately 4 mm, making it easy to insert into a pipeline through a single access point for distributed transient pressure measurement. The usefulness of the fibre optic pressure sensors for transient-based pipeline leak detection is validated through laboratory experiments. The measurement from each
individual fibre optic sensor is generally consistent with conventional piezo-resistive pressure
transducers over a wide frequency range. The sensor array configuration enables the
determination of the directional information of waves, therefore enhancing the ability of
pipeline defect detection and localisation
Omenn Syndrome in Two Infants with Different Hypomorphic Variants in Janus Kinase 3
Get PDF\ua9 The Author(s) 2024.Biallelic null or hypomorphic variants in JAK3 cause SCID and less frequently Omenn syndrome. We investigated homozygous hypomorphic JAK3 mutations in two patients, and expression and function of a novel JAK3R431P variant in Omenn syndrome. Immunophenotyping of PBMC from the patient with the novel JAK3R431P variant was undertaken, by flow cytometry and Phosflow after stimulation with IL-2, IL-7, and IL-15. JAK3 expression was investigated by Western blotting. We report two patients with homozygous hypomorphic JAK3 variants and clinical features of Omenn syndrome. One patient had a previously described JAK3R775H variant, and the second had a novel JAK3R431P variant. One patient with a novel JAK3R431P variant had normal expression of JAK3 in immortalised EBV-LCL cells but reduced phosphorylation of STAT5 after stimulation with IL-2, IL-7, and IL-15 consistent with impaired kinase activity. These results suggest the JAK3R431P variant to be hypomorphic. Both patients are alive and well after allogeneic haematopoietic stem cell transplantation. They have full donor chimerism, restitution of thymopoiesis and development of appropriate antibody responses following vaccination. We expand the phenotype of hypomorphic JAK3 deficiency and demonstrate the importance of functional testing of novel variants in disease-causing genes
Dupilumab Treatment Leads to Rapid and Consistent Improvement of Atopic Dermatitis in All Anatomical Regions in Patients Aged 6 Months to 5 Years
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The Oakland Sail 1985-02-11
No full textAuthor Alex Haley encourages others to find their "Roots" ; Two Detroit men arrested; Visitors break Hamlin window ; New requirements for arts and science majors ; Champagne proposes action on higher education report ; Cassette players should be selected with care; skill ; Dodge farmhouse to be renovated ; Sleep-in; demonstration planned: Students protest all-female dorm proposal ; EDITORIAL: Sail defends against abusive accusations ; LETTERS: Student angered by articles ; Meet the Editor ; Let's get metaphysical ; Features: Refreshing music from Fast Tracks ; Shag Shoppe stylist doesn't just cut hair ; Play addresses racial issues ; Adjustments confronts social problems ; Student settles into a university lifestyle ; SPORTS: Basketball bounces back in league ; Lake Superior snatches championship victory ; Pioneers dunk Bulldogs; prepare for championships ; Knuth adds sparkle to OU starting lineup ; Students petition for more weight room time ; No more Mr. Nice Guy - Kampe ; "Take a break
Measurement of Muscular Activity Associated With Peristalsis in the Human Gut Using Fiber Bragg Grating Arrays
No full textAuthor version made available under Publisher copyright policy.Diagnostic catheters based on fibre Bragg gratings (FBG’s) are proving to be highly effective for measurement of the muscular activity associated with peristalsis in the human gut. The primary muscular contractions that generate peristalsis are circumferential in nature; however, it has long been known that there is also a component of longitudinal contractility present, acting in harmony with the circumferential component to improve the overall efficiency of material movement. We report on the development of, and latest results from, catheter based sensors capable of detecting both forms of muscular activity. While detection of the circumferential contractions has been possible using solid state, hydraulic, and pneumatic sensor arrays in the oesophagus and anorectum, FBG based devices allow access into the complex and convoluted regions of the gut below the stomach. We report early results from FBG catheters used during trials of novel therapies in patients with both slow transit constipation and faecal incontinence. In addition, there have been relatively few reports on the measurement or inference of longitudinal contractions in humans. This is due to the lack of a viable recording technique suitable for real-time in-vivo measurement of this type of activity over extended lengths of the gut. We report preliminary data on the detection of longitudinal motion in lengths of excised mammalian colon using an FBG technique that should be viable for similar detection in humans. The longitudinal sensors have been combined with pressure sensing elements to form a composite catheter that allows the relative phase between the two components to be detected. The output of both types of catheter has been validated using digital video mapping in an ex-vivo animal preparation using lengths of rabbit ileum
