2,227 research outputs found
Antibacterial hydrogel coating in joint mega-prosthesis: results of a comparative series
No full textPurposeJoint mega-prosthesis after bone tumors, severe trauma or infection is associated with high rates of post-surgical septic complications. A fast-resorbable antibacterial hydrogel coating (DAC (R), Defensive Antibacterial Coating) has previously been shown to be able to significantly reduce surgical site infection in various clinical settings. Aim of the present study was to evaluate the safety and efficacy of the DAC hydrogel coating to prevent early periprosthetic joint infection after joint mega-prosthesis.MethodsIn this three-centers, case-control study, 43 patients, treated with an antibacterial hydrogel coated mega-prosthesis for oncological (N=39) or non-oncological conditions (N=4), were retrospectively compared with 43 matched controls, treated with mega-implants without the coating. Clinical, laboratory and radiographic examinations were performed to evaluate the occurrence of post-surgical infection, complications and adverse events.ResultsAt a mean follow-up of 2 years, no evidence of infection or adverse events were observed in the DAC-treated group, compared to six cases of post-surgical infection in the control group.ConclusionThis matched case-control study shows that a fast-resorbable, antibiotic-loaded coating can be safely used to protect joint mega-prosthesis, providing a reduction of early surgical site infections with no side effects. Larger prospective trials with longer follow-ups are warranted to confirm this report.Trial registrationRS1229/19 (Regina Elena National Cancer Institute Experimental Registry Number
Trattamento del tumore a cellule giganti (TCG) del radio distale: studio multicentrico
No full textIl radio distale è la terza sede più frequentemente coinvolta dal tumore a cellule giganti dell’osso
(TCG), tumore istologicamente benigno che nella sua forma aggressiva ha un comportamento destruente
e infiltrante le parti molli. La tecnica chirurgica di scelta nel Grado 3 e in selezionati casi di
Grado 2 è la resezione en-bloc della lesione.
La ricostruzione del radio distale è tutt’ora una sfida per le difficoltà legate alla scarsa copertura dei
tessuti molli, ai rapporti di contiguità con le strutture vascolo nervose e ai rapporti articolari con le
ossa del carpo.
Diverse tecniche chirurgiche ricostruttive sono state utilizzate: artrodesi con autograft o allograft,
traslocazione ulnare, innesto autologo vascolarizzato o libero di perone prossimale, sostituzione
protesica, artroplastica osteoarticolare con allograft di radio distale.
Questo studio vuole valutare i risultati del trattamento del TCG del radio distale confrontando le
diverse tecniche ricostruttive in termini di complicanze locali e risultati funzionali
Ewing's Sarcoma: An Analysis of miRNA Expression Profiles and Target Genes in Paraffin-Embedded Primary Tumor Tissue.
No full textThe molecular mechanism responsible for Ewing's Sarcoma (ES) remains largely unknown. MicroRNAs (miRNAs), a class of small non-coding RNAs able to regulate gene expression, are deregulated in tumors and may serve as a tool for diagnosis and prediction. However, the status of miRNAs in ES has not yet been thoroughly investigated. This study compared global miRNAs expression in paraffin-embedded tumor tissue samples from 20 ES patients, affected by primary untreated tumors, with miRNAs expressed in normal human mesenchymal stromal cells (MSCs) by microarray analysis. A miRTarBase database was used to identify the predicted target genes for differentially expressed miRNAs. The miRNAs microarray analysis revealed distinct patterns of miRNAs expression between ES samples and normal MSCs. 58 of the 954 analyzed miRNAs were significantly differentially expressed in ES samples compared to MSCs. Moreover, the qRT-PCR analysis carried out on three selected miRNAs showed that miR-181b, miR-1915 and miR-1275 were significantly aberrantly regulated, confirming the microarray results. Bio-database analysis identified BCL-2 as a bona fide target gene of the miR-21, miR-181a, miR-181b, miR-29a, miR-29b, miR-497, miR-195, miR-let-7a, miR-34a and miR-1915. Using paraffin-embedded tissues from ES patients, this study has identified several potential target miRNAs and one gene that might be considered a novel critical biomarker for ES pathogenesis
D’Annunzio ‘grecista’ in appendice a Primo vere
No full textThe first time Gabriele d’Annunzio’s literary activity dealt with the classical antiquity dates back directly to 1879, when the author published his first poetic collection: Primo vere. It only includes four poetic translations from Horace Odes, but a new improved edition was republished in 1880 including twenty-three translations of nineteen Latin poems (from Catullus, Tibullus and most importantly from Horace) and of four Homeric hymns. A thorough analysis of the translations from ancient Greek allowed to discover the stylistic tendencies of the poet-translator and food for the though concerning the relationship between ancient Greek poetry and Dannunzian works
Efficacy of trabectedin in advanced soft tissue sarcoma: Beyond lipo- and leiomyosarcoma
No full textManagement of long bone metastases: Recommendations from the Italian Orthopaedic Society bone metastasis study group
No full textThe purpose of this article is to outline the current approach to patients affected by metastasis to the long bones and to present a clinical and surgical algorithm available for clinicians and for future research. A modern approach to patients affected by long bone metastasis in fact requires a multidisciplinary contest where oncologists, radiotherapists, surgeons and physical therapists cooperate with a shared vision, in order to provide the best possible integrated treatments available. The authors of this article constitute the Bone Metastasis Study Group of the Italian Orthopaedic Society (SIOT): a national group of orthopedic tumor surgeons who are dedicated to studying the approach, techniques and outcomes of surgery for metastatic tumours of the musculoskeletal system. © 2014 Informa UK, Lt
Atypical Lipomatous Tumors: Should They be Treated Like Other Sarcoma or Not? Surgical Consideration from a Bi-Institutional Experience
No full textCT-guided radiofrequency ablation of painful intra-articular osteoid osteoma in children: Is there a concern for cartilage damage?
No full textObjective: To evaluate the safety and efficacy of computed tomography-guided percutaneous radiofrequency ablation (PRFA) in the management of uncommon and technically challenging intra-articular osteoid osteoma in children. Material and methods: From December 2018 to September 2022, 16 children with intra-articular osteoid osteoma, including ten boys and six girls, were treated at two tertiary centers with percutaneous CT-guided RF ablation using a straight monopolar electrode. The procedures were carried out under general anesthesia. Post-procedural clinical outcomes and adverse events were assessed through clinical follow-up. Results: Technical success was achieved in all of the participating patients. Clinical success with relief of symptomatology throughout the period of follow-up was achieved in 100% of the patients. No persistence or recurrence of pain occurred during the follow-up period. No immediate or delayed adverse effects were observed. Conclusion: PRFA is shown to be technically feasible. Clinical improvement can be achieved with a high rate of success in the treatment of children with difficult-to-treat intra-articular osteoid osteomas
Primo Levi: the educational resources of a polyhedric writing. Didactic proposals for primary schools
No full textreservedPrimo Levi è principalmente conosciuto per essere sopravvissuto ad Auschwitz e per aver scritto delle opere di testimonianza su questa terribile esperienza. In realtà, egli è un autore fortemente poliedrico, la cui produzione abbraccia ambiti, temi e generi molto diversi e non solo legati alla Shoah. Questa grande varietà costituisce una risorsa importante per gli insegnanti, in quanto all’interno dell’opera leviana è possibile individuare tanti testi potenzialmente utilizzabili con gli alunni, anche della scuola primaria. Sulla base di tale considerazione, è stata progettata e condotta la ricerca in questa sede riportata, avente lo scopo di trarre evidenze che potessero confermare o smentire l’ipotesi secondo cui Primo Levi può essere proposto, con i dovuti accorgimenti pedagogico-didattici, anche a bambini frequentanti la scuola primaria. Tale ricerca è stata articolata in due fasi principali. La prima si è basata sulla somministrazione di un questionario rivolto a persone attive in ambito educativo e/o letterario, volto a rilevare le loro opinioni rispetto alla domanda di ricerca: dalle risposte dei partecipanti è emerso che la maggioranza di essi conosceva Levi a un livello piuttosto superficiale e lo riteneva un autore adeguato ad alunni dalla scuola secondaria in poi. La seconda fase ha previsto invece una sperimentazione presso la scuola primaria “Manzoni” di Limena (PD), nella quale due testi scritti da Levi sono stati proposti agli alunni di una classe quarta: i dati raccolti attraverso conversazioni, osservazioni, questionari e analisi dei prodotti realizzati dai bambini hanno nel complesso confermato l’ipotesi di ricerca formulata.Primo Levi is primarily known for surviving Auschwitz and for writing testimonial works about this terrible experience. Actually, he is a highly versatile author, whose work encompasses various fields, themes, and genres not only related to the Shoah. This great variety is an important resource for teachers, as within Levi’s body of work, many texts can be found that are potentially suitable for students, even in primary school. Based on this consideration, the research presented here was designed and conducted with the aim of gathering evidence to confirm or refute the hypothesis that Primo Levi can be introduced, with appropriate pedagogical and didactic adjustments, to children attending primary school. This research was divided into two main phases. The first was based on a questionnaire administered to individuals active in the educational and/or literary fields, aimed at investigating their opinions on the research question: the participants’ responses showed that the majority had only a rather superficial knowledge of Levi and considered him suitable for students from secondary school onwards. The second phase involved an experiment conducted at the “Manzoni” primary school in Limena (PD), in which two texts written by Levi were presented to a fourth-grade class: the data collected through conversations, observations, questionnaires, and analysis of the children's works overall confirmed the research hypothesis
Primo, the Turkish child
No full textTitle: Primo, Türk çocuğu (Primo, the Turkish child) Originally Published: The fist part of the story (‘How he was born’) was published in Genç kalemler, Selanik, 1911. The second part (‘How he died’) was published in Türk sözü, Istanbul, 1914. Language: Ottoman Turkish The excerpts used are from a 1970 edition of collected stories: Ömer Seyfettin, Bomba – Bütün eserleri (Ankara: Bilgi, 1970), pp. 7–15, 29–32, 34, 38, 39, 57–60, 71–74. About the author Ömer Seyfeddin [1884, Gönen, Balıkesir (..
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