81 research outputs found
A World of Occupations: Life Through the Lens of Persons Who Are Experiencing Homelessness
No full textAbstract
Date Presented 3/31/2017
This research examined meanings ascribed to daily occupations of persons experiencing homelessness. Participants used photographs to document occupations. Q-sort and one-on-one interviews were used to enrich data. Thematic outcomes highlight occupational therapy’s distinct value with this population.
Primary Author and Speaker: Carol Ann Lambdin-Pattavina
Additional Authors and Speakers: Catherine Peirce, Alexandra Marous, Cody Wipperman, Ariella Bitton, Melanie Baldzicki</jats:p
Predikce termostability proteinů se zaměřením na protilátky
No full textThermostability is key to successful protein engineering and therapeutic antibody development; accurate prediction accelerates the identification of stable proteins and the design of robust variants. This thesis evaluates zero- shot and supervised machine learning approaches for thermostability predic- tion, with a focus on antibodies. We achieve state-of-the-art performance on the public AbProp dataset-483 antibodies with melting temperatures measured by differential scanning fluorimetry (DSF)-reaching a Spearman correlation of 0.49 in the zero-shot setting and 0.69 with supervised learning. We find that antibody-specific language models do not outperform general models in the zero-shot setting, which may be due to a wider distribution of thermostability in antibodies, resulting from possibly weaker evolutionary pressure for stability and the high variability introduced by their combinato- rial V(D)J origin and somatic hypermutation. We further evaluate zero-shot generalization on the ProteinGym benchmark, showing that our models per- form competitively on unrelated protein domains. We also analyze sequence positions contributing to supervised prediction and observe that antibodies with lambda light chains are, on average, more thermostable than those with kappa chains. Our results underscore the...Termostabilita je klíčová pro úspěšné inženýrství proteinů a vývoj terape- utických protilátek; přesná predikce urychluje identifikaci stabilních proteinů a návrh robustních variant. Tato diplomová práce hodnotí přístupy strojo- vého učení k predikci termostability v režimu zero-shot i s učením s učitelem, se zaměřením na protilátky. Na veřejné sadě AbProp, která obsahuje 483 pro- tilátek s teplotami tání měřenými metodou diferenciální skenovací fluorimet- rie (DSF), překonáváme dosavadní nejlepší výsledky; v režimu zero-shot do- sahujeme Spearmanovy korelace 0,49 a s učením s učitelem 0,69. Zjišťujeme, že jazykové modely specifické pro protilátky v režimu zero-shot nepřekoná- vají obecné modely, což může být způsobeno širším rozdělením hodnot ter- mostability u protilátek, vyplývajícím z pravděpodobně slabšího evolučního tlaku na stabilitu a vysoké variability dané jejich kombinatorickým původem, V(D)J rekombinací, a somatickými hypermutacemi. Dále vyhodnocujeme ge- neralizaci v režimu zero-shot na benchmarku ProteinGym a ukazujeme, že naše modely dosahují konkurenceschopných výsledků i na nesouvisejících pro- teinových doménách. Analyzujeme také sekvenční pozice přispívající k pre- dikci s učitelem a pozorujeme, že protilátky s lehkými řetězci typu lambda jsou v průměru termostabilnější než ty s řetězci...Department of Cell BiologyKatedra buněčné biologiePřírodovědecká fakultaFaculty of Scienc
Discovery of Novel Protein Coding Genes and Antisense Regulatory Transcripts in Eukaryotes
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
The future of Oregon's nursing workforce: analysis and recommendations
No full textTimothy Bates, Emily Shen, & Joanne Spetz, University of California, San Francisco, Jana Bitton & Rick Allgeyer, Oregon Center for Nursing.Title from PDF title page (viewed on November 18, 2022).Covers OCLC #1351088708 and OCLC #1349245310."The Oregon Health Care Workforce Committee was directed by the Oregon Legislature (HB 4003) to conduct a study of Oregon's nursing workforce to identify and describe challenges in addressing staffing shortages in nursing. This study is intended to provide information to inform the legislature and Oregon Health Authority (OHA) in their efforts to address critical concerns about nursing workforce shortages. The study considered all levels of care, including, but not limited to, hospitals, long-term care facilities, community health centers, home health, public health, and schools"--Page 7.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Comparison of targeted selective and whole flock treatment of periparturient ewes for controlling Haemonchus sp. on sheep farms in Ontario, Canada
No full textTransformative Feminist Approach to Tort Law: Exposing, Changing, Expanding - The Israeli Case
No full textTort law developed into a cornerstone of private law through the influence of traditional legal approaches, such as legal realism and economic reasoning. However, second-wave feminist analysis has also transformed tort law in recent years. By comparing U.S. and Israeli cases, the author demonstrates that feminist critique has added a new dimension to this legal field. Chapter One introduces the obstacles that have impeded the mainstreaming of feminist discourse. Chapter Two explores how gender biases inherent and perpetuated in tort law better serve men than women. The eventual exposure of these biases led to feminist-derived changes in Israeli tort law, which is explained in Chapter Three. The final chapter identifies the limitations of current feminist analysis to tort law, and concludes with the author\u27s support for further evolution and application of this analysis
Transformative Feminist Approach to Tort Law: Exposing, Changing, Expanding - The Israeli Case
No full textTort law developed into a cornerstone of private law through the influence of traditional legal approaches, such as legal realism and economic reasoning. However, second-wave feminist analysis has also transformed tort law in recent years. By comparing U.S. and Israeli cases, the author demonstrates that feminist critique has added a new dimension to this legal field. Chapter One introduces the obstacles that have impeded the mainstreaming of feminist discourse. Chapter Two explores how gender biases inherent and perpetuated in tort law better serve men than women. The eventual exposure of these biases led to feminist-derived changes in Israeli tort law, which is explained in Chapter Three. The final chapter identifies the limitations of current feminist analysis to tort law, and concludes with the author\u27s support for further evolution and application of this analysis
Ordinary Words: Towards a New Understanding of the 19th Century Mormon Male Diary
No full text“It is hard to believe that any group of comparable size, with the possible exception of the Puritans and the Quakers, has been as relentless as the Mormons in writing diaries and autobiographies.” So wrote Davis Bitton, in the Introduction of the 1977 publication Guide to Mormon Diaries and Autobiographies, an index of nearly 3,000 published and unpublished works. Bitton, a close friend and colleague of Mormon History Scholar Leonard Arrington worked with Arrington for decades to create “a research program of [God’s] people’s history.” At the heart of that program was and continues to be the diary. Bitton and Arrington used diaries to build their compendious social and religious histories, to craft life histories of prominent and not-so-prominent Latter-day Saints, and to tell their own stories as Arrington noted in his autobiography, Adventures of a Church Historian, “The principal sources for this book are my diaries, letters, and other personal papers….” And so it’s been for diarists and historians through time – creating, keeping, maintaining, preserving and using written records of their own lives and of their contemporaries and antecedents. In this paper, the author looks at a 19th Century Mormon male diary as not only a source of information about a man and his era, but as a text which can reveal a specific kind of literary writing
Identification of effective treatment criteria for use in targeted selective treatment programs to control haemonchosis in periparturient ewes in Ontario, Canada
No full text- …
