687 research outputs found
Author Correction: Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence
No full textIn this article the grant number ERC-2018-AdG GWAS2FUNC 834057 relating to European Research Council for Danielle Posthuma was omitted. The original article has been corrected
Genetics of intellectual ability and disability: The importance of common variants and rare syndromes illustrated by studies of SNAP25 and AUTS2
No full textMeijers-Heijboer, E.J. [Promotor]Posthuma, D. [Promotor]Sistermans, E.A. [Copromotor
Karl Ferdinand Schertz's rationalism and Magia posthuma
No full textKarl Ferdinand Schertz je na domácí půdě málo známý autor. Naopak jeho jméno je velmi známé na celém světě díky jeho dílu Magia posthuma, citovanému Augustinem Calmetem. Kvůli nedostatku biografických údajů a malé dostupnosti jeho knih je Schertz bohužel velmi špatně interpretován a kolují kolem něho různé fámy či negativní kritiky. Karl Ferdinand Schertz byl naopak velmi kultivovaný autor, který se těšil vážené reputaci v kruzích evropských intelektuálů své doby.Karl Ferdinand Schertz is at home a no well known author. On the contrary, his name is known around the world thanks to his work Magia posthuma, which was quoted by Augustin Calmet. Because of his not well available biography and books, Schertz is unfortunately wrong understood and around him circulate various rumors or negative critics. Karl Ferdinand Schertz was on the contrary highly cultured author, who could enjoy a good reputation among the European intellectuals of his time
Karl Ferdinand Schertz\u27s rationalism and Magia posthuma
No full textKarl Ferdinand Schertz je na domácí půdě málo známý autor. Naopak jeho jméno je velmi známé na celém světě díky jeho dílu Magia posthuma, citovanému Augustinem Calmetem. Kvůli nedostatku biografických údajů a malé dostupnosti jeho knih je Schertz bohužel velmi špatně interpretován a kolují kolem něho různé fámy či negativní kritiky. Karl Ferdinand Schertz byl naopak velmi kultivovaný autor, který se těšil vážené reputaci v kruzích evropských intelektuálů své doby.Karl Ferdinand Schertz is at home a no well known author. On the contrary, his name is known around the world thanks to his work Magia posthuma, which was quoted by Augustin Calmet. Because of his not well available biography and books, Schertz is unfortunately wrong understood and around him circulate various rumors or negative critics. Karl Ferdinand Schertz was on the contrary highly cultured author, who could enjoy a good reputation among the European intellectuals of his time
Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis
No full textTwo obsessive-compulsive disorder (OCD) genome-wide association studies (GWASs) have been published by independent OCD consortia, the International Obsessive-Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and the OCD Collaborative Genetics Association Study (OCGAS), but many of the top-ranked signals were supported in only one study. We therefore conducted a meta-analysis from the two consortia, investigating a total of 2688 individuals of European ancestry with OCD and 7037 genomically matched controls. No single-nucleotide polymorphisms (SNPs) reached genome-wide significance. However, in comparison with the two individual GWASs, the distribution of P-values shifted toward significance. The top haplotypic blocks were tagged with rs4733767 (P=7.1 × 10-7; odds ratio (OR)=1.21; confidence interval (CI): 1.12-1.31, CASC8/CASC11), rs1030757 (P=1.1 × 10-6; OR=1.18; CI: 1.10-1.26, GRID2) and rs12504244 (P=1.6 × 10-6; OR=1.18; CI: 1.11-1.27, KIT). Variants located in or near the genes ASB13, RSPO4, DLGAP1, PTPRD, GRIK2, FAIM2 and CDH20, identified in linkage peaks and the original GWASs, were among the top signals. Polygenic risk scores for each individual study predicted case-control status in the other by explaining 0.9% (P=0.003) and 0.3% (P=0.0009) of the phenotypic variance in OCGAS and the European IOCDF-GC target samples, respectively. The common SNP heritability in the combined OCGAS and IOCDF-GC sample was estimated to be 0.28 (s.e.=0.04). Strikingly, ∼65% of the SNP-based heritability in the OCGAS sample was accounted for by SNPs with minor allele frequencies of ⩾40%. This joint analysis constituting the largest single OCD genome-wide study to date represents a major integrative step in elucidating the genetic causes of OCD
Representing nature in Elizabeth Posthuma Simcoe’s Diary: an examination of Toronto’s colonial past (Canada)
No full textIn this article the author examines how gender, class, and race are important factors in the construction of historical discourses of nature. Using a close reading of the diary of a government official’s wife at the turn of the nineteenth century, three themes of colonialism appear. The contradictions of rationalizing the landscape through cartography, counting nature using botany and
natural history, and romanticizing the landscape through painting and nature writing, highlight how the colonial project was a complex weave of ideas about nature, as commodity, scientific fact, and moral instruction. By exploring the diverse media in Elizabeth Posthuma Simcoe’s Diary – maps, paintings, and writings – a nuanced picture of an upper-class, white woman’s
role in the Upper Canadian colonial project is drawn in relief. The article explores the ways that historic discourses of nature remain in cities and are easily (and often uncritically) incorporated in current day geographies. The author argues that the colonial past must be thoroughly interrogated in order to understand how discourses of nature have been constructed to serve certain interests, disguise the processes of colonialism, and reinforce certain ideas about gender and nature in the present
Rheology and Changes in Structure of Thermotropic Liquid Crystalline Polymers
No full textApplied Science
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