162 research outputs found

    Re-assembly of the genome of Francisella tularensis subsp. holarctica OSU18.

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    Francisella tularensis is a highly infectious human intracellular pathogen that is the causative agent of tularemia. It occurs in several major subtypes, including the live vaccine strain holarctica (type B). F. tularensis is classified as category A biodefense agent in part because a relatively small number of organisms can cause severe illness. Three complete genomes of subspecies holarctica have been sequenced and deposited in public archives, of which OSU18 was the first and the only strain for which a scientific publication has appeared. We re-assembled the OSU18 strain using both de novo and comparative assembly techniques, and found that the published sequence has two large inversion mis-assemblies. We generated a corrected assembly of the entire genome along with detailed information on the placement of individual reads within the assembly. This assembly will provide a more accurate basis for future comparative studies of this pathogen

    Merged_PacBio.Cluster.fasta.gz

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    PacBio October 2016<br

    PR1.fa.gz

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    PR1 v3.0Chromosome level assembly of a Puerto Rican Male Individual FASTA file</div

    PR1_v3.0_heterozygous_sites.vcf.gz

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    PR1 v3.0Heterozygous sites corresponding to the Puerto Rican Male assembly VCF file</div

    CHARACTERISTIC ASPECTS OF THE DANUBE DELTA LAKES

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    The study area is a unique zone called the Danube Delta. The name "delta" derives from the Greek "delta" because of its equilateral triangle shape. Inside this triangle there is a positive relief represented by beams and islands, as well as a negative relief such as canals, marshes, ponds, lakes or Danube arms. The research methods used the statistical data provided by the competent bodies, which were processed and analyzed. It used the computerized processing that generated tables and graphs.The delta hydrography is represented by the Danube's arms, lakes, ponds, marshes, lakes, ponds, canals and sahale. The lakes are distributed throughout the delta, and, as mentioned by P. Gâtestescu in 1969, are concentrated in several lacustral complexes: Sireasa, Storm, Pardina, Matiţa-Merhei, Dranov, Gorgova-Isac and Roşu-Puiu and Zătoanele. The 2005-2010 interval captures the lakes in the Danube Delta in a predominantly good ecological state for almost all chemical compounds, from oxygen, to copper, zinc, iron, nickel

    THE ROLE OF EDUCATIONAL MANAGEMENT IN PROMOTING SUSTAINABLE LOCAL DEVELOPMENT

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    An adequate education and educational management in the spirit of sustainable development is a necessity applicable at the level of all national and world economies. The situation highlights that, among the 17 objectives contained in the Agenda, the one specific to educational management is also introduced, through which it tends to approach and apply measures to ensure a quality, inclusive and fair education, as well as a promotion of learning opportunities throughout life for all individuals, directed towards sustainable development. Education, the level of individual education, as well as the level of community education, has a fundamental role in the awareness and understanding of the concept of sustainable development, in the formation of skills and beliefs to apply it in practice. Without adequate education, without an effective educational system, sustainable economic and social development remains a difficult goal to achieve. Precisely for this reason, an educational management suitable for sustainable development is imperatively necessary

    Investigating the electrohydrodynamic effect (EHDE) for macroscopic actuation

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    This is the thesis written by the author in fulfilment of his Final Year Project (FYP) requirement for Bachelor of Engineering (Electrical and Electronics Engineering) for Academic Year (AY) 17/18. The purpose of this thesis is to examine of the electrohydrodynamic Effect (EHDE) for macroscopic actuation, for the phenomenon that is explained through literature review and theories. The thesis is broken down into 3 main portion- namely the calculation, the simulation and the experiment. For the calculation, it is to tabulate the results of different formula in plotting on graphs to see the variation of factor and how it will affect the end result. For the simulation, it is to see if the concept of electric field, the outcome it is as expected of having a non-uniform electric field. Lastly, the experiment will further enhance and validate the previous two steps taken.Bachelor of Engineerin

    Опыт клиничeского использования информационной системы поддержки ультразвуковoго исследования „SonaRes”

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    Universitatea de Stat de Medicină şi Farmacie N. TestemiţanuSummary: „SonaRes” is a system developed by a team of computer scientists and doctors (which includes the author) to support ultrasound diagnosis of pathologies of the hepato-pancreatic-biliary area. Assessment of the influence of the system on ultrasound diagnosis was performed by physicians with experience in the field and resident physicians (beginners) on a group of 87 patients with cholecystopathies. The main directions of the evaluation were: quality of documentation, diagnostic relevance of findings provided by the system, the effect (impact) of training and scientific importance (research). The system in general has been well accepted and confirmed its reliability. After some experience using the system, the beginners demonstrated both an increase in diagnostic accuracy and better results in training. Experts mentioned the main impact in standardizing documentation (reports, statistics) and the role of the second opinion in difficult cases, as well the role of the theoretical and academic source of file collection. „SonaRes” has proved its usefulness and its benefits as intelligent ultrasound examination assistance, able to offer conclusions, based on a standardized nomenclature, at least the same as those written by hand by doctors. There remain questionable moments of dispute settlement, particularly if the solutions accepted by the system do not coincide with those of doctors.Резюме: Система „SonaRes” разработана группой ученых-программистов и врачей (в том числе автор) для поддержки ультразвуковой диагностики патологии гепато-панкреато-билиарной области. Оценка влияния данной информационной системы на процесс ультразвуковой диагностики проводилась экспертами и начинающими врачами на группе из 87 пациентов с холецистопатиями. Основные направления оценки были: качество документации, точность диагностических выводов представленных системой, влияние на профессиональную подготовку врачей и исследовательские возможности. Система в целом была хорошо принята и подтвердила свою надежность. После определенного опыта использования системы начинающие врачи отметили повышение точности диагностики и оценили образовательную роль системы. Эксперты констатировали значимое влияние на стандартизацию документации (протоколы исследования, статистика) и важную роль второго мнения в сложных случаях. Система „SonaRes” доказала свою значимость и преимущества в качестве информационной интеллектуальной системы поддержки принятия решений в ультразвуковом исследовании, предоставляющей выводы практически не уступающих в точности диагнозам врачей написанных от руки. Тем не менее, остаются спорными моменты урегулирования разногласий в случае, когда решения принятые системой не совпадают с мнением врачей

    Self-adapting Backfilling Scheduling for Parallel Systems

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    We focus on non-FCFS job scheduling policies for parallel systems that allow jobs to backfill, i.e., to move ahead in the queue, given that they do not delay certain previously submitted jobs. Consistent with commercial schedulers that maintain multiple queues where jobs are assigned according to the user-estimated duration, we propose a self-adapting backfilling policy that maintains multiple job queues to separate short from long jobs. The proposed policy adjusts its configuration parameters by continuously monitoring the system and quickly reacting to sudden fluctuations in the workload arrival pattern and/or severe changes in resource demands. Detailed performance comparisons via simulation using actual Supercomputing traces from the Parallel Workload Archive indicate that the proposed policy consistently outperforms traditional backfilling
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