25 research outputs found
Reflecting on good mathematics teaching: knowing, nurturing, noticing
No full textThe chapter "Reflecting on good mathematics teaching: Knowing, nurturing, noticing" was written by Susan Oesterle (Douglas College Faculty). The book brings together recent research and commentary in secondary school mathematics from a breadth of contemporary Canadian and International researchers and educators. It is both representative of mathematics education generally, as well as unique to the particular geography and culture of Canada. The chapters address topics of broad applicability such as technology in learning mathematics, recent interest in social justice contexts in the learning of mathematics, as well as Indigenous education. The voices of classroom practitioners, the group ultimately responsible for implementing this new vision of mathematics teaching and learning, are not forgotten. Each section includes a chapter written by a classroom teacher, making this volume unique in its approach. Part of the "Advances in mathematics education" series. Provided by publisher.book chapte
Developing young children's understanding of place-value using multiplication and quotitive division
No full textThis paper focuses on selected findings from a study that explored the use of multiplication and division with 34 five- and six-year-old children from diverse cultural and linguistic backgrounds. The focus of instructional tasks was on working with groups of ten to support the understanding of place value. Findings from relevant assessment tasks and children’s work highlighted the importance of encouraging young children to move from unitary (counting by ones) to tens-structured thinking
Functional Characterization of cGKI Substrate Proteins IRAG and ESP1/CRP2 in the Human Gastrointestinal Tract
No full textDer NO/cGMP/cGKI-Signaltransduktionsweg hemmt in glatten gastrointestinalen Muskelzellen hormoninduzierte Kalziumtransienten und führt so zu einer Relaxation der glatten Muskulatur. Zwei Substratproteine der cGKI im Gastrointestinaltrakt sind bekannt: IRAG und ESP1/CRP2. Im Rahmen dieser Arbeit wurden mehrere IRAG mRNA- und Proteinvarianten im Gastrointestinaltrakt des Menschen identifiziert. Drei C-terminal trunkierte Isoformen inhibieren in vitro in glatten Kolonmuskelzellen die IRAG-vermittelte Hemmung von Kalziumtransienten und haben damit dominant negative Funktionen. Das cGKI Effektorprotein ESP1/CRP2 wird im gesamten Gastrointestinaltrakt exprimiert, transloziert cGKI-abhängig in die Zellkernmembran von glatten Kolonmuskelzellen und ist vermutlich ein cGKII-abhängiges Strukturprotein mit bisher unbekannter Funktion.No/cGMP/cGKI signaling in gastrointestinal muscle cells inhibits hormone induced calcium transients and induces relaxation of smooth muscle cells. In the gastrointestinal tract two substrate proteins of cGKI are known: IRAG and ESP1/CRP2. In this study different IRAG mRNA and protein variants in the human gastrointestinal tract were identified. C-terminal truncated isoforms in vitro inhibit IRAG induced inhibition of colonic smooth muscle calcium transients and hence have dominant negative functions. The cGKI downstream protein ESP1/CRP2 is expressed along the gastrointestinal tract, translocates cGKI dependent to the membrane of the nucleus, and could function as a cGKI dependent structure protein with unknown function
Jörn Steigerwald, Daniela Watzke (Hg.): Reiz ‒ Imagination ‒ Aufmerksamkeit. Erregung und Steuerung von Einbildungskraft
No full textFunktionelle Charakterisierung der cGKI Substratproteine IRAG und ESP1 CRP2 im humanen Gastrointestinaltrakt
No full textFunktionelle Charakterisierung der cGKI Substratproteine IRAG und ESP1 CRP2 im humanen Gastrointestinaltrakt
No full textWhy (and how) to regulate Power Exchanges in the EU market integration context?
No full textPower Exchanges (PXs) are key market institutions in open and market-based electricity industries. This paper aims at contributing to the ongoing debate on why and how to regulate Power Exchanges in the EU market integration context. . The paper starts by stating that two different types of PXs have to be distinguished, i.e. "Merchant" PXs and the "Cost of Service Regulated" PXs. The paper continues by comparing the typical incentives of these two types of PXs to perform the basic PX tasks in an isolated national market and in a market integration context. The paper concludes by deriving from this analytical frame the most relevant regulatory actions..Regulation, Exchanges, Grid access, Power Markets.
Piano music. Selections.
No full text"Volume 1 contains a biographical sketch of the author by Richard Aldrich.
Truncated IRAG variants modulate cGMP-mediated inhibition of human colonic smooth muscle cell contraction
No full textvon Werder A, Mayr M, Schneider G, Oesterle D, Fritsch RM, Seidler B, Schlossmann J, Hofmann F, Schemann M, Allescher HD, Schmid RM, Saur D. Truncated IRAG variants modulate cGMP-mediated inhibition of human colonic smooth muscle cell contraction. Am J Physiol Cell Physiol 301: C1445-C1457, 2011. First published August 24, 2011; doi:10.1152/ajpcell.00304.2010.-Nitric oxide (NO) induces relaxation of colonic smooth muscle cells predominantly by cGMP/cGMP-dependent protein kinase I (cGKI)-induced phosphorylation of the inositol 1,4,5-trisphosphate receptor (IP3R)-associated cGMP kinase substrate (IRAG), to block store-dependent calcium signaling. In the present study we analyzed the structure and function of the human IRAG/MRVI1 gene. We describe four unique first exon variants transcribed from individual promoters in diverse human tissues. Tissue-specific alternative splicing with exon skipping and alternative splice donor and acceptor site usage further increases diversity of IRAG mRNA variants that encode for NH2- and COOH-terminally truncated proteins. At the functional level, COOH-terminally truncated IRAG variants lacking both the cGKI phosphorylation and the IP3RI interaction site counteract cGMP-mediated inhibition of calcium transients and relaxation of human colonic smooth muscle cells. Since COOH-terminally truncated IRAG mRNA isoforms are widely expressed in human tissues, our results point to an important role of IRAG variants as negative modulators of nitric oxide/cGKI-dependent signaling. The complexity of alternative splicing of the IRAG gene impressively demonstrates how posttranscriptional processing generates functionally distinct proteins from a single gene
A weather related causal analysis on consolidated delay at Newark Liberty International Airport
No full textThe closure of the European airspace due to the eruption of the Icelandic volcano Eyjafjallajokull in 2010 proved a major challenge for airlines and aviation authorities on a global scale. In contrast, more seasonal adverse meteorological conditions afflict many airports in the northern eastern seaboard of the United States. Newark Liberty International Airport (KEWR) is a representative airport that endures severe weather based delays. This dissertation explores the utilisation of Bayesian Networks (BN) and heuristic analyses to investigate weather based delays at Newark Liberty International airport (KEWR). In particular, it aims to understand which weather variables (namely, precipitation, visibility and wind) have the most impact on weather based delays at KEWR in contrast to past studies that have studied more generic weather phenomena (e.g. thunderstorms) at the same airport. An analysis using temporal functionality with Bayesian Networks (BN) software and heuristic analyses was conducted. Data extracted from weather and aviation based websites was extracted using software. The quality of the information was cross referenced with official data sources and validated using BN tools. The results revealed a causal correlation chain between crosswinds above a certain threshold and high delays at KEWR at various points in the experimentation. Though other meteorological elements examined had an impact on delays, airport authorities and airlines can mitigate these factors to a certain scale using Federal Aviation Authority (FAA) approved technology and training. Consequently, the implications could be significant on existing FAA and regional policy with Ground Delay Program (GDP) and Noise Abatement Procedures (NAP). These policies can be profound and far reaching for airlines, in terms of operating procedures and fuel cost implications. These findings can further alter the balance between efficiency, public safety and airline costing affecting all major stakeholders as this dissertation will investigate
