138 research outputs found
Two Distinct Pathways Support Gene Correction by Single-Stranded Donors at DNA Nicks
No full textSummaryNicks are the most common form of DNA damage. The mechanisms of their repair are fundamental to genomic stability and of practical importance for genome engineering. We define two pathways that support homology-directed repair by single-stranded DNA donors. One depends upon annealing-driven strand synthesis and acts at both nicks and double-strand breaks. The other depends upon annealing-driven heteroduplex correction and acts at nicks. Homology-directed repair via these pathways, as well as mutagenic end joining, are inhibited by RAD51 at nicks but largely independent of RAD51 at double-strand breaks. Guidelines for coordinated design of targets and donors for gene correction emerge from definition of these pathways. This analysis further suggests that naturally occurring nicks may have significant recombinogenic and mutagenic potential that is normally inhibited by RAD51 loading onto DNA, thereby identifying a function for RAD51 in maintenance of genomic stability
Joan Nicks Research Collection, 1910-2023, n.d.
No full textJoan Nicks is a retired faculty member in the Department of Communication, Popular Culture, and Film at Brock University. Her main research interest is the local popular culture of Niagara Falls. In 2002 she co-edited a book with Jeannette Sloniowski titled Slippery Pastimes: Reading the Popular in Canadian Culture, and in 2010 she co-edited a book with Barry Grant titled Covering Niagara: Studies in Local Popular Culture. In 2022 two books that she authored were published, titled Lost Movie Theatres, Niagara Falls, Ontario: movie-going in a cross-border city and Disappearing Motels, Niagara Falls, Ontario: cultural decline of a post-war travel icon.The collection contains material compiled by Joan Nicks while conducting research about local popular culture in Niagara Falls, Ontario. She is the author of two books, titled Lost Movie Theatres, Niagara Falls, Ontario: movie-going in a cross-border city and Disappearing Motels, Niagara Falls, Ontario: cultural decline of a post-war travel icon. Most of the material consists of video and audio cassettes of interviews, photographs, and slides. Some of the photographs show performers in blackface. Some promotional material and legal documents concerning Niagara Falls theatres is also included, as well as a map of “Little Italy” in Niagara Falls (1922)
Internet Pseudonyms vel Nicks: An Onomastic Characterization and Usage
No full textCelem artykułu było przede wszystkim wyjaśnienie kwestii teoretycznych związanych z charakterystyką onomastyczną nazw przypisanych indywidualnie użytkownikom interaktywnych usług w Internecie, określanych mianem pseudonimów internetowych czy też nicków. Chodziło o to, czy można te nazwy klasyfikować jako pseudonimy, czy też może należałoby uznać, że reprezentują one nową kategorię antroponimiczną. Autor rozważań stoi na stanowisku, że istnieją przesłanki do tego, by uznać, że nick jako typ nazwy osobowej stanowi odmianę pseudonimu, przy tym ma on pewne wyróżniające właściwości, które ujawniają się szczególnie mocno w związku z komunikacyjnym medium. Uwagi o charakterze teoretyczno-opisowym zostały w pracy uzupełnione o prezentację materiału w postaci nazw używanych na forum portalu film.web. Zamierzeniem autora było pokazanie zróżnicowania form pseudonimicznych w przestrzeni internetowej, jednak bez wchodzenia w szczegóły związane z indywidualną inspiracją nazewniczą, za to ze zwróceniem uwagi na różne przykłady licencji onimicznej, która w komunikacji za pośrednictwem komputera ma charakter wielowymiarowy, przyciąga np. uwagę ze względu na asocjacje w planie apelatywnym języka, nawiązaniami interonimicznymi, różnymi formami o charakterze neograficznym, dostarcza przykładów przekraczania ograniczeń i granic językowych (wykorzystanie w nazwach języka angielskiego).The major goal of the study has been to explain theoretical issues connected with the onomastic characterization of names used by internet users, i.e., the so called nicks. Can they be regarded as traditional pseudonyms, or do they constitute a unique anthroponymic category? The author suggests that nicks are a subcategory of pseudonyms, but they have certain properties that become especially salient in connection with the communicative medium.
Theoretical and descriptive considerations have been supplemented with nicks used on the film.web website. An attempt has been made to show the diversity of nicks but without unnecessary detail as regards the motivation for individual naming decisions. Instead, onus is put on various examples of onymic license, which has a multidimensional nature in computer-mediated communication. For example, it becomes noticeable through its associations on the appellative language plane, through interonymic relations, or through various neo-geographical forms. This license also underlies the processes of extending the boundaries of a particular language (e.g. English elements are used in Polish nicks)
Über das Maß der entkommenden Menge eines quasiregulären Analogons des Sinus
No full textQuasiregular maps are a natural generalisation of holomorphic maps to higher dimensions. Recently, there is an increasing interest in studying the dynamics of quasiregular maps on the -dimensional Euclidian space. Until now, not much is known about the dynamical behaviour of general quasiregular maps. However, quasiregular analogues of the complex exponential map as well as of trigonometric functions have been constructed and turned out to behave quite similarly to their counterparts in the plane.
In this thesis, we examine the dynamical behaviour of certain quasiregular maps on the -dimensional Euclidian space which can be seen as quasiregular analogues of complex trigonometric functions. This class was introduced by Bergweiler and Eremenko in 2011. We will denote a member of this class by \Sin(x). We are interested in the iteration of these maps, in particular in the escaping set consisting of all points that tend to infinity under iteration.\\
We prove the following results: Theorem 1 is an analogue of a well known result by McMullen from 1987. We show that for f(x)=\lambda\Sin(x), where , the escaping set has positive Lebesgue measure. In fact, this is also true for the fast escaping set consisting of all points that essentially escape as fast as possible.\\
Theorem 2 states that the measure of the non-escaping set of in vertical square beams is finite. This corresponds to a result in the plane by Schubert from 2008 concerning the escaping set of in vertical strips. Again, this is also true for the fast escaping set.\\
We also use the map \Sin(x) to construct a quasiregular power mapping which is similar to a quasiregular power mapping introduced by Mayer based on Zorich maps. We discuss some properties of the map .
Theorem 3 then states that for , the composition of the power mapping with a suitable quasiregular analogue of the trigonometric functions yields a quasiregular map with non-escaping set of finite measure. This generalises a result by Hemke from 2005. In the last section, we discuss the sharpness of Theorem 3.Quasireguläre Abbildungen sind eine natürliche Verallgemeinerung holomorpher Abbildungen auf höhere Dimensionen. In letzter Zeit gibt es ein zunehmendes Interesse an der Untersuchung des dynamischen Verhaltens von quasiregulären Abbildungen auf dem -dimensionalen euklidischen Raum. Noch ist nicht viel über das dynamische Verhalten von allgemeinen quasiregulären Abbildungen bekannt. Allerdings wurden quasireguläre Analoga der komplexen Exponentialabbildung sowie von trigonometrischen Funktionen konstruiert, welche sich aus dynamischer Sicht sehr ähnlich wie ihre Gegenstücke in der Ebene verhalten.
In dieser Arbeit untersuchen wir das dynamische Verhalten von bestimmten quasiregulären Abbildungen auf dem -dimensionalen euklidischen Raum, welche als quasireguläre Analoga von komplexen trigonometrischen Funktionen angesehen werden können. Diese Klasse wurde von Bergweiler und Eremenko im Jahr 2011 eingeführt. Wir bezeich\-nen eine Abbildung dieser Klasse mit \Sin(x). Wir interessieren uns für die Iteration dieser Abbildungen, insbesondere für die entkommende Menge bestehend aus all jenen Punkten, welche unter Iteration nach unendlich streben.\\
Wir beweisen die folgenden Ergebnisse: Theorem 1 ist ein Analogon von einem bekann\-ten Resultat von McMullen aus dem Jahr 1987. Wir zeigen, dass die entkommende Menge von f(x)=\lambda\Sin(x) für alle positives Lebesguemaß hat. In der Tat stimmt dies auch für die schnell entkommende Menge , welche die Punkte enthält, die im Wesentlichen so schnell wie möglich entkommen.\\
Theorem 2 besagt, dass das Maß der nichtentkommenden Menge von in vertikalen Balken endlich ist. Dies entspricht einem Resultat in der Ebene von Schubert aus dem Jahr 2008 über die entkommende Menge von in vertikalen Streifen. Theorem 2 gilt ebenfalls für die schnell entkommende Menge.\\
Außerdem verwenden wir die Abbildung \Sin(x) um eine quasireguläre Potenzfunktion zu konstruieren. Diese Abbildung ähnelt einer von Mayer vorgestellten quasire\-gulären Potenzfunktion, welche auf Zorich Abbildungen aufbaut. Wir diskutieren einige Eigenschaften der Abbildung .
Theorem 3 besagt schließlich, dass die Komposition von mit einem geeigneten quasiregulären Analogon der trigonometrischen Funktionen eine quasireguläre Abbildung mit nichtentkommender Menge von endlichem Maß ergibt, sofern . Dies verallgemeinert ein Ergebnis von Hemke aus dem Jahr 2005. Im letzten Abschnitt diskutieren wir die Schärfe von Theorem 3
Entkommende Mengen von ganzen und quasiregulären Abbildungen
No full textA transcendental entire function is a holomorphic function on the whole complex plane which is not a polynomial. The Julia set of an entire function denotes the set of all points in \C where the iterates of do not form a normal family in the sense of Montel. Many mathematicians investigated the iteration of these functions. Even the simplest example of a transcendental entire function, namely the exponential map with \lambda \in \C\setminus\{0\}, is of rich structure. Devaney and Krych showed in 1984 that for the exponential family , where , the Julia set consists of uncountably many pairwise disjoint simple curves tending to , which they called hairs.
Recently, the iteration of a natural higher-dimensional analogue of holomorphic maps, the so-called quasiregular maps, became of great interest. A special family of quasiregular functions, the so-called Zorich maps, was introduced by Zorich in 1969 and can be consi-dered as a higher-dimensional counterpart of the exponential family.
Bergweiler showed in 2010 that for several Zorich maps hairs also exist.
In this thesis we want to focus on the differentiability of hairs for transcendental entire functions and Zorich maps. A first result was given by Viana in 1988, who proved that the hairs of the exponential family are smooth. In the first part of this thesis, we show that his result generalizes to the Zorich maps considered by Bergweiler under some mild additional regularity assumptions.
At first glance it seems that the regularity of the function transfers to the regularity of the hairs. In the second part of this thesis we construct in contrast to the first result a transcendental entire function of the so-called Eremenko-Lyubich class, where every hair is nowhere differentiable.Eine ganz transzendente Funktion ist eine auf der gesamten komplexen Zahlenebene holomorphe Funktion, welche nicht polynomiell ist. Die Juliamenge einer ganzen Funktion bezeichnet die Menge aller Punkte in \C, in welchen die Iterierten von keine normale Familie im Montelschen Sinne bilden. Viele Mathematiker befassten sich mit der Iteration solcher Funktionen. Selbst der einfachste Fall einer ganz transzendenten Funktion, nämlich der Exponentialfunktion mit \lambda \in \C\setminus\{0\}, ist von reicher Struktur. Devaney und Krych haben 1984 gezeigt, dass für die Exponentialfamilie mit die Juliamenge aus überabzählbar vielen paarweise disjunkten einfachen Kurven nach besteht, welche von ihnen Haare genannt werden.
In letzter Zeit gab es ein wachsendes Interesse an der Iteration eines natürlichen höherdimensionalen Analogons holomorpher Funktionen, den sogenannten quasiregulären Funktionen. Eine spezielle Familie quasiregulärer Funktionen, den von Zorich 1969 eingeführten und heute nach ihm benannten Zorichfunktionen, kann als höherdimensionales Analogon der Exponentialfamilie angesehen werden. Bergweiler hat 2010 gezeigt, dass für gewisse Zorichfunktionen Haare existieren.
In dieser Arbeit legen wir unser Augenmerk auf die Differenzierbarkeit von Haaren von Zorich- und ganz transzendenten Funktionen. Ein erstes Resultat wurde von Viana im Jahr 1988 gegeben, in welchem er zeigt, dass die Haare der Exponentialfamilie glatt sind. In dem ersten Teil dieser Arbeit zeigen wir, dass sein Resultat für die Zorichfunktionen, welche Bergweiler betrachtet hat, unter schwachen Zusatzvoraussetzungen an die Regularität der Funktion verallgemeinert werden kann.
Auf den ersten Blick könnte man vermuten, dass sich die Regularität der Funktion auf die Regularität der Haare überträgt. Im Gegensatz zum ersten Resultat zeigen wir im zweiten Teil dieser Arbeit, dass es eine ganz transzendente Funktion aus der sogenannten Eremenko-Lyubich-Klasse gibt, bei der jedes Haar nirgendwo differenzierbar ist
Jämförande studie mellan traditionella seminarier & webbseminarier i marknadsföringssyfte
No full textTitel: Comparative study between traditional seminars and webinars for marketing purpose. Level: Final assignment for Bachelor Degree in Business Administration Author: Peter Nicks and Alexander Widell Supervisor: Aihie Osarenkhoe Date: 2011 – January Aim: We want to examine how businesses can use webinars to supplement or replace seminars in its industrial marketing. When should businesses use seminars, when should they use webinars and when should they use a combination of the two? Method: We have chosen to do a combination of quantitative and qualitative research. We see the benefits of both methods for our research. Many issues raised in the aim are difficult to respond to by only using one method. The quantitative part is the questionnaires completed by participants and the qualitative part consists of two interviews. All investigated events are made at a large international IT company. Result & Findings: The results of our studied seminars shows that the larger events the greater the need for a physical seminar. We have therefore concluded that we must choose different types of seminar for various events. For minor events, it is better to just use webinars. For the big events, you always should have a traditional seminar but it is possible to combine with a webinar to reach out to even more customers. Suggestions for future research: What are the results of similar studies in other industries? Make repeated studies on a wider basis than the three events that we implemented. Further research into how seminar and webinar affect sales. It was something we set as a target at the beginning of this study, but we were not able to measure. Contribution of the thesis: With this paper, we hope to provide guidance to organizations that want to make use of webinars for marketing purposes. Key words: marketing, webinar, workshop, customers, I
Health Hazard Evaluation Report: HETA 93-0797-2624: Nicks Silica Company, Jackson, Tennessee
No full textIn response to a request from the Mine Safety and Health Administration, an investigation was begun into the prevalence of silicosis at specific ground silica (14808607) operations by conducting a medical evaluation of active and retired miners. This investigation centered around Nicks Silica Company (SIC-1446), Jackson, Tennessee. The study population included workers with 1 year or greater cumulative tenure subsequent to the opening of the mill in the grinding area or in areas downstream of the grinding process. A medical survey was conducted which included a questionnaire, spirometry, and a single view posterior/anterior (PA) chest X-ray. None of the 12 current and former workers participating in the survey had changes on their chest X-ray consistent with silicosis. One participant showed an abnormal spirometry pattern. Three reported chronic respiratory symptoms. All four participants with positive findings were current cigarette smokers. Because of the long latency usually associated with chronic nodular silicosis, the finding is not sufficient to conclude that current silica dust exposures are without any adverse effect. The author recommends that the medical monitoring program be modified to include classification of chest X-rays by a B-reader
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Real meromorphic functions and a result of Hinkkanen and Rossi
No full textLet f be a transcendental meromorphic function such that all but finitely many of the poles of f and zeroes of f' are real. Generalising a result of Hinkkanen and Rossi (Proc. Amer. Math. Soc. 92 (1984) 72–74), we characterize those f such that f' takes some nonzero value only finitely often, and show that all but finitely many of the zeroes of f'' are real in this case. We also prove a related asymptotic result about real meromorphic functions with a nonzero deficient value α and only finitely many nonreal zeroes, poles and α-points
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Rational deficient functions of derivatives of mappings in the classes <i>S</i> and <i>B</i>
No full textLet f be transcendental and meromorphic in the plane of finite lower order with a bounded set of finite critical and asymptotic values. It is shown that a rational deficient function of any derivative of f is zero at infinity. If instead f has arbitrary order and a finite set of critical and asymptotic values, then any rational deficient function of f' must have a multiple zero at infinity. Furthermore, if such f has finite lower order then f' admits no rational deficient functions other than 0
La prise en compte des contraintes environnementales en élevage: code de bonnes pratiques et aspects réglementaires
No full textpeer reviewedAs all other activities, livestock production represents a risk of nuisances for the environment. The author describes the risks of causing water pollution from applying livestock wastes to land and the risks of air pollution from odours and ammonia. The agricultural practices which minimise the nuisances and the Belgian environmental protection laws concerning the building of animal houses and the disposal of farm wastes are presente
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