1,721,052 research outputs found
sj-xlsx-2-ctj-10.1177_17407745231182417 – Supplemental material for Data monitoring committees in pediatric randomized controlled trials registered in ClinicalTrials.gov
No full textSupplemental material, sj-xlsx-2-ctj-10.1177_17407745231182417 for Data monitoring committees in pediatric randomized controlled trials registered in ClinicalTrials.gov by Tiago Machado, Beatrice Mainoli, Daniel Caldeira, Joaquim J Ferreira and Ricardo M Fernandes in Clinical Trials</p
sj-docx-1-ctj-10.1177_17407745231182417 – Supplemental material for Data monitoring committees in pediatric randomized controlled trials registered in ClinicalTrials.gov
No full textSupplemental material, sj-docx-1-ctj-10.1177_17407745231182417 for Data monitoring committees in pediatric randomized controlled trials registered in ClinicalTrials.gov by Tiago Machado, Beatrice Mainoli, Daniel Caldeira, Joaquim J Ferreira and Ricardo M Fernandes in Clinical Trials</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Propranolol vs. placebo or other beta-blockers in patients with hyperthyroidism: A Systematic Review and Meta-Analysis
No full text**Type of project:** Systematic review
**Principal Investigator and guarantor:** Daniel Caldeira, MD, PhD.
**Institution:** Faculdade de Medicina da Universidade de Lisboa, Portugal. Centro de Estudos de Medicina Baseada na Evidência (CEMBE)
Departments: CCUL@RISE - Centro Cardiovascular da Universidade de Lisboa; Laboratory of Clinical Pharmacology and Therapeutics, Faculdade de Medicina, Universidade de Lisboa, Portugal.
*Project aimed to be the Master Thesis of Joana Rita Cerdeira de Oliveira (Medicine Student)*
Funding: None.
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Rationale:
The main action of beta-blockers in hyperthyroidism is to ameliorate sympathomimetic and hypermetabolic symptoms, with less effect in heat intolerance, weight loss and hyperphagia. (Feely, 1983; Wiersinga, 1991) The action of propranolol and some other beta-blockers, the majority, although not all, with membrane-stabilizing properties, is not only symptomatic management, but also to decrease thyroid hormones levels, therefore having an overall effect in the control of this disease. This effect on hormones appears to be dependent of the beta-blocking agent, dosage, and duration of treatment, as well as the changes in pharmacokinetics caused by thyroid hormones effects in cardiovascular, hepatic, and renal functions. (De Leo et al., 2016; Feely, 1983; Geffner & Hershman, 1992) In the case of propranolol, some studies have shown it inhibits 5’-deiodination, therefore interfering with the peripheral conversion of T4 into T3. (Wiersinga, 1991).
We aimed to conduct a systematic review with meta-analysis of the RCTs studying the effects of propranolol against placebo and different interventions to better ascertain the clinical effect of propranolol in patients with hyperthyroidism.
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**PICOS data:**
Patients: Patients with hyperthyroidism/thyrotoxicosis
Intervention: Propranolol
Comparator/Control: Placebo; Other non-selective beta-blockers (NSBB); Cardioselective beta-blockers (SBB); Anti-thyroid drugs (secondary comparator)
Outcome: Thyroid Stimulating Hormone (TSH)/thyrotropin, Free T4, Total T4, Free T3, Total T3, Reverse T3, Palpitations/tachycardia, tremor
Study design: Randomized controlled trials
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Brief Methodological and Statistical Analysis Plan:
Databases for Search: MEDLINE, Cochrane Library (CENTRAL) and Web of Science
Meta-analysis planned: Yes. STATA 17.0 or R
Primary analysis: Network meta-analysis (frequentist and bayesian analyses) including the placebo, NSBB and SBB.
Secondary analysis: Network meta-analysis of primary analysis and adding the data of studies with anti-thyroid drugs compared with beta-blockers.
Risk of Bias evaluation: Cochrane RoB 2.0
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Milestones:
Project Initiation: September 2023
Literature Search Date: January 2024
Expected Project end: June-July 202
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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