6,318 research outputs found
Spironolactone: diuretic or disease‐modifying drug in heart failure with preserved ejection fraction?
Full text linkThis article refers to 'Diuretic and renal effects of spirono-lactone and heart failure hospitalizations: a TOPCAT Americas analysis' by A.P. Kalogeropoulos et al., published in this issue on pages 1600-1610. With monthly costs of approximately US$12 in the USA and €5 in Europe, spironolactone is by a landslide the most cost-effective drug in the management of heart failure (HF) with reduced ejection fraction (HFrEF). In the Randomized Aldactone Evaluation Study (RALES), the treatment of 10 patients with HFrEF in New York Heart Association functional class III or IV saved one life after 2 years, 1 a number that still looks favourable in comparison with any other HF drug. The story is more nuanced in HF with preserved ejection fraction (HFpEF), but given the high number of treatment strategies that have failed over the past 15 years, the results of spironolactone in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial remain among the best we have to offer our patients. In the TOPCAT trial, spironolactone use was associated with a non-significant 10% lower relative risk for all-cause mortality after 3.3 years, and a borderline significant 17% relative risk reduction for HF readmission was observed. 2 However, the primary endpoint of the trial, which combined both individual endpoints together with aborted cardiac arrest, was not statistically significant. Post hoc analyses of the TOPCAT trial identified significant regional differences in patient profiles, event rates and compliance with the study medication, demonstrating that the trial would have been positive if it had been limited to the subpopulation recruited in America or with objective evidence for HFpEF under the form of elevated natriuretic peptide levels. These somewhat ambiguous results make it even more important to understand how spironolactone exerts its beneficial effects in HF. Spironolactone is a prodrug that is rapidly metabolized in its major active metabolites with a long half-life (t 1/2): 7α-thiomethylspironolactone (t 1/2 = 13.8 h) and canrenone The opinions expressed in this article are not necessarily those of the Editors of the European Journal of Heart Failure or of the European Society of Cardiology.F.H.V. is supported by a Fellowship of the Belgian American Educational Foundation (B.A.E.F.) and by the Special Research Fund (BOF) of Hasselt University (BOF19PD04). Conflict of interest: none declared.Verbrugge, FH (corresponding author), Hasselt Univ, Fac Med & Life Sci, Biomed Res Inst, Campus Diepenbeek,Agoralaan Gebouw D, B-3590 Diepenbeek, Belgium.
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Kevin Brockmeier, Fiction Reading
No full textOctober 25, 2013, Ulrich Museum of Art, Wichita State UniversityAward winning author Kevin Brockmeier, reads from his work.University Libraries, Department of English, Department of Women's Studies, Watermark Books & Cafe, Ulrich Museum of Ar
Dr. Kevin Pelletier – Faculty Author Interview
No full textDr. Kevin Pelletier, Associate Professor of English, discusses his new book, Apocalyptic Sentimentalism: Love and Fear in US Antebellum Literature, published recently by the University of Georgia Press. The book provides powerful insights into the relationship between nineteenth-century sentimentality, religious discourse, and antislavery reform
Kevin Fenton: A Reading
No full textThe John S. Lucas Great River Reading Series (GRRS) hosts Winona native and author Kevin Fenton. Fenton will read from his new novel Cyan Magenta Yellow Black published by Black Lawrence Press, 2025.
Kevin Fenton is the author of Merit Badges, which won the AWP Prize for the Novel and the Friends of the American Writers Award, and Leaving Rollingstone, which Patricia Hampl called “the most important memoir to come out of the Midwest (or anywhere) in years.” He works as an advertising writer and creative director; in that capacity, he’s published essays in the design quarterlies Émigré and Eye (London), the anthology Looking Closer 2: Critical Writing On Graphic Design, and the UX design blog Boxes and Arrows. He got a slightly better education than he deserved at Beloit College, the University of Minnesota Law School, and the University of Minnesota MFA program. He lives in St Paul with his wife Ellen and his greyhound Evie
'Web of Life' - Profile of Kevin Petrie in Printmaking Today Winter 2024
No full textKevin Petrie, Professor of Creative Practice at the University of Sunderland, uses print to explore the novels and philosophy of Iris Murdoch writes Dr Miles Leeson. This is a 1200 word profile of Kevin Petrie and his recent work for 'Printmaking Today' which is the journal of the Royal Society of Painter Printmakers. The piece gives an overview of Petrie's creative practice focusing on the novels and thinking of Dame Iris Murdoch (1919-1999). The piece discusses Petrie's evolving model of creative practice for this project: reading the novels, sketching to visualise elements, developing and combining images in the studio and then reengagement with Murdoch (through the community, literature and archive). Petrie's 'Other Journeys' and 'Web of Life' exhibitions are discussed.
The author, Dr Miles Leeson, is the Director of the Iris Murdoch Research Centre at University of Chichester and Visiting Research Fellow at Kingston University. He is the lead editor of the Iris Murdoch Review, the Series Editor of ‘Iris Murdoch Today’ with Palgrave Macmillan, and has published widely on Murdoch’s work. He published Iris Murdoch: Philosophical Novelist (Continuum) in 2010, the edited collection Incest in Contemporary Literature (Manchester University Press, 2018), the festschrift Iris Murdoch: A Centenary Celebration (Sabrestorm Fiction, 2019), the edited collection Iris Murdoch and the Literary Imagination (Palgrave Macmillan, 2022) and is currently writing Iris Murdoch: Feminist.
Four prints by Kevin Petrie are reproduced with the text:
Untangle
2024
Etching from two plates with Chine Collé
Paper 38x29cm Image 14.8x12.5cm
Photo: Dave Williams
Friends
2023
Etching with Chine Collé
Paper 38x29cm Image 14.8x12.5cm
Photo: Dave Williams
Love
2023
Etching with Chine Collé
Paper 38x29cm Image 14.8x12.5cm
Photo: Dave Williams
What lies beneath
2024
Lithograph
38.5x28cm
Printed by Lee Turner at Hole Editions Newcastle
Photo: Dave William
Dr. Kevin Cherry – Faculty Author Interview
No full textDr. Kevin Cherry, Assistant Professor of Political Science,discusses his new book, Plato, Aristotle, and the Purpose of Politics, published recently by Cambridge University Press. In this book, he compares the views of Plato and Aristotle about the practice, study and the purpose of politics
Dr. Kevin Cruz - Faculty Author Interview
No full textDr. Kevin Cruz, Assistant Professor of Management in the Robins School of Business, discusses his recent article, “Perceptions of psychological contract breach and perceptions of co-worker exclusion: The moderating effects of collectivism and individualism,” in Occupational Health Science. Dr. Cruz’s research interests focus on employee – employer relationships, employee – team relationships and employee – co-worker relationships
Major, Kevin
No full textThe fonds consists of records created and received by Kevin Major as a Canadian writer, editor and teacher between 1974 and 2014. Material includes correspondence with family, friends, writers, editors, agents and readers; contracts and royalty statements; material related to author readings and appearances at literary festivals; school visits and other author appearances; literary awards received by the author; literary awards juries the author participated in; as well as general media coverage about the author. The fonds contains materials related to each of the author’s published works, including administrative documents, research, manuscript drafts and media coverage. The fonds also includes documentation about the author’s personal life, including materials related to his education, his teaching career, travel, and family life.
The types of documents include letters and e-mails, transcripts, posters, contracts, reports, research notes, manuscripts, certificates, books, newspapers and journals, photographs, slides, interviews, and audio/visual materials in a variety of media: cassette tapes, CDs, CD-ROMs, DVDs and VHS tapes
Barer, Julie & Wilson, Kevin : Publishing Panel; November 26th, 2018
No full textContents:
All tracks Panel [complete]
Track 01 Introduction
Track 02 Q&A
Digital Projects SAN: folder location for wav and mp3 files: /J:\Elliston Working\11-27-2018 (Julie Barer and Kevin Wilson
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