1,720,965 research outputs found
NON-INVASIVE BIOMARKERS IN BREAST CANCER EARLY DIAGNOSIS
No full textIntroduction: Breast cancer is the most commonly diagnosed malignancy among women worldwide and remains a leading cause of cancer-related death. Early detection plays a critical role in reducing mortality rates, improving prognosis and enhancing the effectiveness of therapeutic interventions. However, current screening strategies such as mammography and core needle biopsy (CNB) suffer from significant limitations, including reduced sensitivity in dense breast tissue, high false-positive rates and limited ability to characterize tumor biology at early stages. These limitations underscore the need for innovative, minimally invasive diagnostic tools. Liquid biopsy, which enables the analysis of tumor-derived biomarkers in body fluids, offers a promising alternative for early and accurate detection of malignancies. The integration of proteomic and epigenetic biomarkers derived from liquid biopsies could revolutionize early breast cancer diagnostics by improving precision and reducing reliance on invasive procedures.
Methods: This work was conducted within the RENOVATE study, a prospective academic trial carried out at IRCCS Ospedale Policlinico San Martino (Genoa, Italy). Women presenting with suspicious breast lesions (BI-RADS 3–5, ≤2 cm) and healthy controls with negative mammograms were enrolled. Blood and urine samples were collected from all participants. Plasma and cfDNA were analyzed using a multi-omics approach combining high-throughput proteomic platforms (SomaScanTM, Olink®), ELISA validation assays and epigenomic profiling techniques including cfMeDIP-seq and Oxford Nanopore sequencing. The primary objective was to identify circulating biomarkers capable of distinguishing breast cancer from benign conditions.
Results: Multi-omics analysis revealed distinct molecular profiles in cancer patients compared to those with benign lesions or healthy controls. Proteomic profiling identified significantly altered levels of specific circulating proteins, including HPGDS, which demonstrated strong discriminative power. Epigenetic analysis of cfDNA via cfMeDIP-seq uncovered differentially methylated regions (DMRs) associated with genes involved in tumorigenesis, immune regulation, and cellular proliferation. These findings support the potential of circulating biomarkers to serve as a non-invasive diagnostic signature for early-stage breast cancer.
Conclusions: This study provides compelling evidence for the clinical utility of liquid biopsy in early breast cancer diagnosis. The combination of proteomic and epigenetic signatures derived from blood samples enables molecular-level discrimination between malignant and benign breast lesions, offering a non-invasive, accurate, and patient-friendly diagnostic tool. By reducing unnecessary biopsies and enabling earlier therapeutic intervention, this approach has the potential to improve patient outcomes and support the broader implementation of precision oncology in clinical practice. Future larger-scale validation studies are essential to confirm these findings and transition liquid biopsy-based diagnostics into routine breast cancer screening protocols
GUD (Genoa University Design): A Magazine about Architecture, Design and Cities 10 (InterATTIVE / InterACTIVE)
No full textInterATTIVE: issue edited by Nicola Valentino Canessa and Chiara Centanaro.
Contributions by Manuel Gausa, Barbara Lino, Annalisa Contato, Xavier Tumay Ferrari, Giovanna Tagliasco, Anna Terracciano, Federica Maria Lorusso, Paolo Di Nardo, Alessandro Spennato, Gabriele Oneto, Anna Toth, Renata Paola Dameri, Martina Massari, Fabio Favilli, Elena Polleri, Claudia Porfirione, Stella Rigo Femke, Monica Bruzzone, Eleonora D’Ascenzi, Chiara Centanaro, Nicola Valentino Canessa
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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