10,759 research outputs found

    Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy

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    Maternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor. Angiotensin II (Ang II) is a potent vasoconstrictor that increases concomitant with sFlt-1 during pregnancy. Therefore, we speculated that Ang II may promote the expression of sFlt-1 in pregnancy. Here we report that infusion of Ang II significantly increases circulating levels of sFlt-1 in pregnant mice, thereby demonstrating that Ang II is a regulator of sFlt-1 secretion in vivo. Furthermore, Ang II stimulated sFlt-1 production in a dose- and time-dependent manner from human villous explants and cultured trophoblasts but not from endothelial cells, suggesting that trophoblasts are the primary source of sFlt-1 during pregnancy. As expected, Ang II-induced sFlt-1 secretion resulted in the inhibition of endothelial cell migration and in vitro tube formation. In vitro and in vivo studies with losartan, small interfering RNA specific for calcineurin and FK506 demonstrated that Ang II-mediated sFlt-1 release was via Ang II type 1 receptor activation and calcineurin signaling, respectively. These findings reveal a previously unrecognized regulatory role for Ang II on sFlt-1 expression in murine and human pregnancy and suggest that elevated sFlt-1 levels in preeclampsia may be caused by a dysregulation of the local renin/angiotensin system

    Orthogonality of Jahn-Teller axes in a dinuclear Cu(II) complex bridged by one F- anion

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    The dinuclear Cu(II) complex bridged by a single F- anion has orthogonal Jahn-Teller axes, which induce a ferromagnetic interaction between the intramolecular Cu(II) ions

    Six Overtures Composed by C. F. Abel. Adapted for the Harpsichord or Piano Forte : being Opera First / By the Author

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    SIX OVERTURES COMPOSED BY C. F. ABEL. ADAPTED FOR THE HARPSICHORD OR PIANO FORTE : BEING OPERA FIRST / BY THE AUTHOR Six Overtures Composed by C. F. Abel. Adapted for the Harpsichord or Piano Forte : being Opera First / By the Author (1) Cover (1) Titelseite (2) Overture I. (3) Overture II. (8) Overture III. (12) Overture IV. (16) Overture V. (20) Overture VI. (24

    Alfonso de Palencia: author of the vocabulario romance latín in the ms. escorial f-II-10?

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    El descubrimiento de dos folios de un incunable sevillano que transmite el mismo vocabulario que el ms. Esc. f-II-10 permitió concluir que se trata este del primer vocabulario romance-latín que llegó a la imprenta. Gracias al prólogo conservado en uno de los folios, contamos con más datos para acercarnos al problema del autor. En este artículo repasaré los avances respecto de la fecha y la autoría, para analizar luego las numerosas similitudes que presenta con el Universal Vocabulario de Palencia. Esta investigación ofrecerá, además de un estudio detallado de las fuentes lexicográficas de ambos vocabularios, varias pruebas relativamente contundentes que permiten identificar al autor.The discovery of two incunable folios that transmit the same vocabulary as the MS Esc. f-II-10 led to the conclusion that this was the first Romance-Latin vocabulary to be printed in a Castilian press. The prologue that is preserved in one of the folios offers new data to approach the problem of its author ship. In this paper I will begin by summarizing previous insights regarding date and authorship, before offering an analysis of the countless similarities that this text has with Palencia’s Universal Vocabulario. As well as providing a detailed study of the lexicographical sources of both vocabularies, this research offers several compelling pieces of evidence that allow to identify the authorFil: Hamlin, Cinthia Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto de Investigaciones Bibliográficas y Crítica Textual. IIBICRIT - Subsede "Seminario Orduna"; Argentina. Universidad de Buenos Aires; Argentin

    Letter from Robert F. Martin, Surgeon, June 11, 1946

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    Written on official letterhead of the U.S. Department of Justice Immigration and Naturalization Service in Crystal City, Texas, Robert F. Martin, the Surgeon and Medical Officer in Charge writes in support of Mr. Harukichi Watanabe, who was employed as an orderly from November 9, 1944 through the date of this letter. He describes Watanabe as an ideal employee and recommends Watanabe for any work "in which he considers himself qualified."Collection of notes, articles, correspondence, photographs, and term papers collected by Yukio Mochizuki, a student at CSU Dominguez Hills, while researching Japanese American incarceration and Japanese Peruvian internment during World War II

    Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)

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    In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
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