102,993 research outputs found
Letter re: thanks for book
No full textLetter from J.N. Dougan thanking Amon Carter for "Garner of Texas
Letter from B. F. Dowell to N. G. Taylor, 1869
No full textAsked payment for three vouchers in favor of Thomas Sherwood, which were filed by him for Dougan & Wall
The immune responses to bacterial antigens encountered in vivo at mucosal surfaces.
No full textMammals have evolved a sophisticated immune system for handling antigens encountered at their mucosal surfaces. The way in which mucosally delivered antigens are handled influences our ability to design effective mucosal vaccines. Live attenuated derivatives of pathogens are one route towards the development of mucosal vaccines. However, some molecules, described as mucosal immunogens, are inherently immunogenic at mucosal surfaces. Studies on mucosal immunogens may facilitate the identification of common characteristics that contribute to mucosal immunogenicity and aid the development of novel, non-living mucosal vaccines and immunostimulators
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Functional cell permeable motifs within medically relevant proteins
No full textIncreasing experimental evidence indicates that short polybasic peptides are able to translocate across the membrane of living cells. However, these peptides, often derived from viruses and insects, may induce unspecific effects that could mask the action of their cargoes. Here, we show that a panel of lysine and/or arginine-rich peptides, derived from human proteins involved in cell signalling pathways leading to inflammation, possess the intrinsic ability to cross intact cellular membranes. These peptides are also capable of carrying a biologically active cargo. One of these peptides, encompassing the cell permeable sequence of the Toll-receptor 4 (TLR4) adaptor protein (TIRAP) and modified to carry a dominant-negative domain of the same TIRAP protein, selectively inhibited the production of pro-inflammatory cytokines upon LPS challenge, in in vitro, ex vivo and in vivo experiments. Docking studies indicated that this inhibition might be mediated by the disruption of the recruitment of downstream effector molecules. These results show for the first time the potential of using for therapy cell permeable peptides derived from human proteins involved in disease
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
The Right to Strike under the United States Constitution: Theory, Practice, and Possible Implications for Canada
No full textAnswering critics of the Canadian Supreme Court's judgment in B.C. Health, the author argues that the Court laid the foundation for a principled and durable doctrine protecting constitutional labour rights, one that goes directly to the heart of the matter — the inequality of workers’ power in the employment relation. In the author’s view, two paths could lead from B.C. Health to the recognition of Charter protec- tion for a right to strike: one that treats the right as an accessory to col- lective bargaining, and one that upholds the right directly on the basis of the Charter values of equality and participation. The author supports the latter approach, contending that constitutional rights should be defined in relation to fundamental values, in a way that is not contingent on time-bound or fact-sensitive assessments about the role of strikes within a particular collective bargaining regime. Although a Charter right to strike may involve the courts in difficult choices about when to defer to legislative policy decisions, and courts may lack the institutional capac- ity to deal effectively with labour law issues, the author points out that judges can look to ILO standards for expert guidance. Noting that the U.S. experience in this area might be of considerable use to Canadians, the author concludes by providing an overview of American case law concerning a constitutional right to strike.Peer reviewe
THE LRP GENE AND ITS ROLE IN TYPE I FIMBRATION IN CITROBACTER RODENTIUM
No full textCitrobacter rodentium is a murine pathogen that is now widely used as an in vivo model for gastrointestinal
infections due to its similarities with human enteropathogens, such as the possession of a locus for enterocyte
effacement (the LEE island). We studied the lrp gene of C. rodentium and found that it encodes a product highly
similar to members of the Lrp (leucine-responsive regulatory protein) family of transcriptional regulators, able
to recognize leucine as an effector and to repress the expression of its own structural gene. In enterobacteria,
Lrp is a global regulator of gene expression, as it controls a large variety of genes, including those coding for
cell appendages and other potential virulence factors. Based on the well-established role of Lrp on the
expression of pilus genes in Escherichia coli, we also studied the role of Lrp in controlling the formation of the
type I pilus in C. rodentium. Type I pili, produced by the fim system, are virulence factors of uropathogens,
involved in mediating bacterial adhesion to bladder epithelial cells. Yeast agglutination assays showed that Lrp
is needed for type I pilus formation and real-time PCR experiments indicated that Lrp has a strong leucinemediated
effect on the expression of the fimAICDFGH operon. Mutant studies indicated that this positive
action is exerted mainly through a positive control of Lrp on the phase variation mechanism that regulates
fimAICDFGH expression. A quantitative analysis of its expression suggested that this operon may also be
negatively regulated at the level of transcription
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