1,721,502 research outputs found

    Dorizzi, T H, WX12884

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    This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/382314Surname: DORIZZI. Given Name(s) or Initials: T H. Military Service Number or Last Known Location: WX12884. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 16806.213409 Item: [2016.0049.14607] "Dorizzi, T H, WX12884

    Dorizzi, H, WX7997

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    This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/382315Surname: DORIZZI. Given Name(s) or Initials: H. Military Service Number or Last Known Location: WX7997. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 40009.213411 Item: [2016.0049.14608] "Dorizzi, H, WX7997

    Procalcitonin to guide antibiotic stewardship in intensive care

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    The usefulness of PCT trends in guiding the duration of antibiotic therapy in septic episodes is limited since it doesn’t take into account some aspects that can affect the PCT levels. In particular: 1) both the aetiology (Gram positive and Gram negative rods, fungi, parasites) and antibiotics prescribed for septic episodes (bactericidal/fungicidal vs bacteriostatic/fungistatic drugs) are not specified. 2) the surgical “source control” of septic episode (e.g. intra-abdominal infections) is not mentioned The lack of an infectious disease specialist in data processing team composed of an intensivist, a statistician and a pulmonologist, could explain the restricted classification of prevalent infections

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Procalcitonin in intensive care: unresolved doubts

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    Procalcitonin (PCT), a test marketed by some twenty years, is available virtually on all the platforms present in clinical laboratories of any size, even if its precise role is still debated. PCT is requested especially by intensive care units (ICU) and it has been included in algorithms to guide the administration of antibiotics (AB). However, several reports concluded that, despite a theoretical physio-pathological basis, there is no unambiguous evidence that the inclusion of PCT in algorithms is effective to guide AB treatment. In 2012 the Cochrane Collaboration concluded that "Further high-quality research is needed to confirm the safety of this approach in intensive care. Moreover, future studies should also establish cost-effectiveness by considering country-specific costs of procalcitonin measurement and potential savings in consumption of antibiotics and other healthcare resources, as well as secondary cost savings due to lower risk of side effects and reduced antimicrobial resistance". In 2015, the National Institute for Clinical Heath Excellence concluded that the test is promising but there is still insufficient evidence to recommend its use to guide the AB treatment of sepsis in ICU. Recently, in a paper published in the Clinical Chemistry journal among the limiting factors preventing widespread use of PCT in sepsis and antibiotic stewardship it was included: the limited availability (and high cost) of PCT, the reluctance showed by clinicians to deescalate antibiotics based on PCT results and the uncertainty about the generalizability of previous studies results. The duration of therapy generally tends to be longer compared to what was recommended by guidelines, and PCT-guided antibiotic discontinuation may be of little benefit in hospitals where duration of therapy is already optimized
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