86,930 research outputs found
Thymectomy and azathioprine in the treatment of type 1 (insulin-dependent) diabetes mellitus.
No full textHealth and sustainability: New gender perspectives
No full textAbstract: - European health systems face important challenges related to the sustainability of health care, both
from an economic point of view and in relation to the quality of health services provided in terms of continuous
improvement of effectiveness, safety, clinical and organisational appropriateness. The ability of EU Member
States to continue to provide high quality care to all, whatever their biological and socio-cultural characteristics,
depends on their health systems becoming more sustainable. Therefore, there is a need to strengthen health
promotion and disease prevention, to invest in primary care systems, to move health care out of the hospital and
into more accessible ambulatory and domestic care, and to develop integrated care practices.
Starting from these premises, the aim of this paper is to present a narrative overview of the main aspects related
to Gender Medicine and its evolution over time. Our critical overview is, therefore, aimed at providing a general
picture of what has been developed by health systems on Gender Medicine, with a particular focus on the
relationship between social sustainability and Gender Medicine.
To achieve our goal, we carry out a systematic literature review in order to understand what has been developed
so far in the area and to highlight the possible evolution of studies in the field and to strengthen the awareness of
the importance of encouraging prevention, training and information programs shared with hospitals, institutions,
health professionals and patient associations.
To the best of the authors' knowledge, this is among the first studies that investigate through a systematic literature
review the phenomenon of gender medicine, especially with reference to the sustainability of the health care
system. Although our analysis needs further investigation, due to the fact that the topic is not yet fully mature,
our initial and preliminary results underline the importance of further investigating gender diversity and assessing
the possibility of promoting a clinical pathway to personalised treatment. In fact, only through a “gender
medicine” approach it is possible to guarantee a real right to health and an effective personalisation of treatments,
thus reinforcing the concept of patient focussed care and contributing to the sustainability of the whole health
system
Medicina di Genere: sfide e opportunità per il Sistema Sanitario Nazionale
No full textLa Medicina di Genere si riferisce allo studio dell’influenza delle differenze biologiche e di genere,
sullo stato di salute di ciascun individuo. L’esame degli indicatori di genere consente di cogliere tutti gli aspetti
che contraddistinguono e definiscono il genere, dalla gestione della vita quotidiana, in relazione ai trattamenti
terapeutici, all’impatto della malattia sul rapporto tra il singolo e il contesto sociale di appartenenza. Il presente lavoro mira ad alimentare il dibattito sulla Medicina di Genere e sulla sua evoluzione nel tempo, evidenziando le barriere e i benefici connessi alla diffusione di una cultura di genere nel Sistema Sanitario Nazionale
Oncolytic virotherapy and microenvironment in multiple myeloma
No full textMultiple myeloma (MM) is a hematologic malignancy characterized by the accumulation of bone marrow (BM) clonal plasma cells, which are strictly dependent on the microenvironment. Despite the improvement of MM survival with the use of new drugs, MM patients still relapse and become always refractory to the treatment. The development of new therapeutic strategies targeting both tumor and microenvironment cells are necessary. Oncolytic virotherapy represent a promising approach in cancer treatment due to tumor‐specific oncolysis and activation of the immune system. Different types of human viruses were checked in preclinical MM models, and the use of several viruses are currently investigated in clinical trials in MM patients. More recently, the use of alternative non‐human viruses has been also highlighted in preclinical studies. This strategy could avoid the antiviral immune response of the patients against human viruses due to vaccination or natural infections, which could invalid the efficiency of virotherapy approach. In this review, we explored the effects of the main oncolytic viruses, which act through both direct and indirect mechanisms targeting myeloma and microenvironment cells inducing an anti‐MM response. The efficacy of the oncolytic virus‐therapy in combination with other anti‐MM drugs targeting the microenvironment has been also discussed
Expression of bovine viral diarrhea virus glycoprotein E2 as a soluble secreted form in a mammalian cell line
No full textBovine viral diarrhea virus (BVDV) membrane-anchored type I glycoprotein E2 is an ∼53-kDa immunodominant glycoprotein inducing the production of neutralizing antibodies in the animal host after natural infection or following immunization with live or killed vaccines. The E2 coding region lacking the transmembrane domain was constructed in a soluble secreted form (secE2) and expressed in the medium of a transiently transfected human cell line. The crude conditioned medium containing secE2 can be potentially employed to develop an enzyme-linked immunosorbent assay antigen for the diagnosis of BVDV infection or for vaccine purposes. Copyright © 2006, American Society for Microbiology. All Rights Reserved
Un esempio di inversione positiva. Evoluzione tettonica delle Unità Lagonegresi (Lucania Centrale, Italia)
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