1,355,387 research outputs found
Declaration of Intention of Thomas Donofrio
No full textDeclaration of Intention to become a citizen of the United States, as filled out and signed by:Thomas Donofrio
Applicant age:38
Occupation:presser
Country of Origin:Italy
Date of Birth:23 July 1881
Sailed to the US aboard the vessel:Scintia
City of residence at time of declaration:Egg Harbor City, NJ
Declaration submitted and sworn on date:19 April 192
Ralph N. Donofrio, U.S. Army Air Corps
No full textThis is a portrait of Ralph N. Donofrio, U.S. Army Air Corps. He is wearing his summer service uniform and smiling widely at the camera. A sign near his left breast pocket reads "RALPH N. DONOFRIO, 44-46N-8A ASN 32956273.
Health and sustainability: New gender perspectives
No full textAbstract: - European health systems face important challenges related to the sustainability of health care, both
from an economic point of view and in relation to the quality of health services provided in terms of continuous
improvement of effectiveness, safety, clinical and organisational appropriateness. The ability of EU Member
States to continue to provide high quality care to all, whatever their biological and socio-cultural characteristics,
depends on their health systems becoming more sustainable. Therefore, there is a need to strengthen health
promotion and disease prevention, to invest in primary care systems, to move health care out of the hospital and
into more accessible ambulatory and domestic care, and to develop integrated care practices.
Starting from these premises, the aim of this paper is to present a narrative overview of the main aspects related
to Gender Medicine and its evolution over time. Our critical overview is, therefore, aimed at providing a general
picture of what has been developed by health systems on Gender Medicine, with a particular focus on the
relationship between social sustainability and Gender Medicine.
To achieve our goal, we carry out a systematic literature review in order to understand what has been developed
so far in the area and to highlight the possible evolution of studies in the field and to strengthen the awareness of
the importance of encouraging prevention, training and information programs shared with hospitals, institutions,
health professionals and patient associations.
To the best of the authors' knowledge, this is among the first studies that investigate through a systematic literature
review the phenomenon of gender medicine, especially with reference to the sustainability of the health care
system. Although our analysis needs further investigation, due to the fact that the topic is not yet fully mature,
our initial and preliminary results underline the importance of further investigating gender diversity and assessing
the possibility of promoting a clinical pathway to personalised treatment. In fact, only through a “gender
medicine” approach it is possible to guarantee a real right to health and an effective personalisation of treatments,
thus reinforcing the concept of patient focussed care and contributing to the sustainability of the whole health
system
Malignant behaviour of primary intracranial Rosai Dorfman disease: A rare presentation of a benign disease
No full textBackground and purpose: The Rosai Dorfman disease (RDD) is a rare and usually benign lymphoproliferative disorder of unknown aetiology, typically characterized by head and neck lymphadenopathies. However, it may occasionally present with primary extra-nodal involvement including the central nervous system. We firstly described the potential malignant behaviour and fatal evolution of primary intracranial RDD. Illustrative case: A 69-year-old woman sought clinical attention for recurrent episodes of headache, fever and malaise associated with bilateral proptosis and left lower limb paresis. The brain MRI revealed bilateral retro-bulbar and fronto-parieto-occipital subdural lesions. The body CT did not show extracranial lesions. A right fronto-parietal craniotomy was performed and a subtotal resection was achieved. The histopathological diagnosis was consistent with RDD. Despite the patient was commenced on high-dose corticosteroids, she developed a worsening respiratory distress syndrome and a rapid systemic disease progression with liver and kidney failure. Given the poor general status, adjuvant medical and radiation therapies were not deemed safe and feasible and the patient died of multi-organ failure a month later. Conclusions: We documented an exceptional case of primary intracranial RDD with malignant behaviour characterized by rapid systemic disease progression and poor prognosis. Although RDD with intracranial location has usually a benign and self-limiting course with good response to adjuvant treatments, it hides a malignant potential that may lead patients to death
Medicina di Genere: sfide e opportunità per il Sistema Sanitario Nazionale
No full textLa Medicina di Genere si riferisce allo studio dell’influenza delle differenze biologiche e di genere,
sullo stato di salute di ciascun individuo. L’esame degli indicatori di genere consente di cogliere tutti gli aspetti
che contraddistinguono e definiscono il genere, dalla gestione della vita quotidiana, in relazione ai trattamenti
terapeutici, all’impatto della malattia sul rapporto tra il singolo e il contesto sociale di appartenenza. Il presente lavoro mira ad alimentare il dibattito sulla Medicina di Genere e sulla sua evoluzione nel tempo, evidenziando le barriere e i benefici connessi alla diffusione di una cultura di genere nel Sistema Sanitario Nazionale
VACCINE DEMAND DRIVEN BY VACCINE SIDE EFFECTS: DYNAMIC IMPLICATIONS FOR SIR DISEASES
No full textFor infections for which the perceived risk of serious disease is steadily low,the perceived risk of suffering some vaccine side effects might become the driving force of the vaccine demand. We investigate
the dynamics of SIR infections in homogeneously mixing populations where the vaccine uptake is a decreasing function of the current(or past)incidence,or prevalence,of vaccine side effects.We define
an appropriate model where vaccine side-effects are modelled as functions of the age since vaccination.
It happens that the vaccine uptake follows its own dynamics independent of epidemiological variables.We show the conditions under which the vaccine uptake lands on a globally stable equilibrium,or steadily oscillates,and the implications of such behaviour for the dynamics of
epidemiological variables. We finally report some unexpected scenarios caused by trends in vaccine side effects
L’azione di governo per la riforma dello sport: la legge delega n. 86/2019 ed i successivi decreti attuativi
No full textIl presente contributo analizza la recente riforma dell’ordinamento sportivo italiano, realizzato a seguito dell’entrata in vigore della legge delega n. 86 del 2019 e dei successivi cinque decreti legislativi attuativi. Vengono, altresì, opportunamente considerati gli interventi normativi in considerazione del rapporto tra l’ordinamento giuridico statale e l’ordinamento sportivo, nazionale ed internazionale
Clinical protection of goats against CpHV-1 induced genital disease with a BoHV-4-based vector expressing CpHV-1 gD
No full textCaprine herpesvirus type 1 (CpHV-1) is an alphaherpesvirus causing genital disease leading to abortion in adult pregnant goats and a systemic disease with high morbility and mortality in kids. Further, Caprine herpesvirus 1 infection represents a valuable large animal model for human herpesvirus induced genital disease, exploitable for pathogenic studies, new vaccines and antiviral molecules testing. Here, the bovine herpesvirus 4 (BoHV-4) based vector derived from an apathogenic isolate of BoHV-4 and expressing the immunodominant CpHV-1 glycoprotein D (BoHV-4-A-gDcpgD106ΔTK) was constructed and its ability to protect goats against CpHV-1 induced genital disease evaluated. The subcutaneous route of recombinant BoHV-4 administration was first tested in vivo/ex vivo by in vivo image analysis and in vitro by goat skin primary cultures preparation and transduction. Next, an exploratory immunization and safety study in goats was performed with two recombinant BoHV4, BoHV-4-A-gDcpgD106ΔTK or BoHV-4-CMV-IgK-gE2gD-TM. In both cases no clinical signs were evident but a good titer of serum neutralizing antibodies was produced in all inoculated animals. When a challenge experiment was performed in a new group of animals using a highly pathogenic dose of CpHV-1, all the vaccinated goats with BoHV-4-A-gDcpgD106ΔTK were protected toward CpHV-1 induced genital disease respect to the unvaccinated control which showed typical vaginal lesions with a high grade of clinical score as well as a long lasting viral shedding. In summary, the data acquired in the present study validate BoHV-4-based vector as a safe and effective viral vector for goat vaccination against CpHV-1 induced genital disease and pave the way for further applications. © 2013 Donofrio et al
Cumulative intracranial tumour volume prognostic assessment: a new predicting score index for patients with brain metastases treated by stereotactic radiosurgery
No full textBrain metastases (BM) represent the most common intracranial malignancy in adults. Limitations of existing prognostic models reduce their predictivity and clinical applicability. The aim of this study is to validate the cumulative intracranial tumour volume prognostic assessment (CITVPA) as a new prognostic score system for patients with BM treated by Stereotactic Radiosurgery (SRS). Between January 2001 and December 2015, 1894 patients underwent Gamma Knife SRS treatment. The CITVPA model was implemented and validated as follows: the CITV cut-offs were identified thanks to a receiver-operating characteristic (ROC) curve analysis; the survival predictive factors were selected through a Cox proportional hazard model; its prognostic power was compared to RPA, SIR and GPA through the Harrel concordance index (HCI). According to the ROC curve analysis, the CITV cut-off values were set at 1.5 and 4.0 cc. Based on the multivariate analysis, the CITVPA model included: age (OR 1.010, 95% CI 1.005–1.015, p < 0.001), KPS (OR 0.960, 95% CI 0.956–0.965, p < 0.001), extracranial metastases (OR 1.287, 95% CI 1.154–1.437, p < 0.001), BM number (OR 1.193, 95% CI 1.047–1.360, p = 0.008), and CITV (OR 1.028, 95% CI 1.020–1.036, p < 0.001). A score between 0 and 1 was attributed to each prognosticator; a global CITVPA score ranging from 0 to 5 was assigned with higher results corresponding to worse outcomes. The CITVPA (HCI = 0.64) exhibited a significantly (p < 0.001) higher prognostic power compared to RPA (HCI = 0.55), SIR (HCI = 0.55) and GPA (HCI = 0.61). The CITVPA represents a reliable prognostic system for patients with BM treated by SRS. However, further prospective and multicentric studies are necessary before its applicability in clinical practice
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