1,720,991 research outputs found
La βασιλεία in Giovanni Geometra e il rapporto in base al diverso βασιλεὺς: alcune considerazioni.
No full textThe article examines the presence of imperial figures in the epigrammatic production of John Geometres, aiming at demonstrating that the poet wanted to use his poetry as an instrument to express his political ideas. In particular, the article aims at showing that even when Geometres is criticising an emperor, this cannot be interpreted as a critic towards the βασιλεία as an institution
Nutritional status in renal transplant recipients evaluated by means of body composition analysis
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Parathyroid hormone and large related C-terminal fragments increase at different rates with worsening of renal function in chronic kidney disease patients. A possible indicator of bone turnover status?
No full textAntibodies for therapeutic uses and the evolution of biotechniques
No full textProtein therapeutics are playing an expanding role in modern medicinal chemistry. Among them, native or engineered molecules exploiting the binding and catalytic potential of the immune repertoire form an extremely exciting and emerging business area. They represent by far the single largest category of biopharmaceutical substances under investigation. The fast increase of this pharmaceutical category paralleled the scientific and technical progress from murine to chimeric, humanized and, finally, human engineered antibodies. Indeed, the development of the phage display technology, allowing libraries of shuffled murine or human antibody binding domains to be screened for affinity against a selected target antigen or activity against a specific reaction substrate, open new perspectives, disclosing the opportunity to circumvent restrictions inherent to the in vivo immunisation. Transgenic technology represents another powerful method for generating fully human monoclonal antibodies against a wide variety of drug targets, while recombinant technology continues to evolve, improving the pharmacodynamic and pharmacokinetic properties of antibody therapeutics, with the production of different antibody constructs or formats, such as bispecific antibodies, diabodies and others, and different functional activities, such as catalysis, cellular internalisation and antigen-mimicking. The aim of the present review is to overview native or recombinant antibodies while discussing the underlying antibody technology, with the aim to favour understanding of the antibody therapeutics that are in use or will enter market in the near future
Assessment of nutritional status and risk of death in maintenance haemodialysis patients
No full textMalnutrition is a major determinant of longterm
outcome of maintenance haemodialysis
(MHD) patients. The aim of this study was to evaluate
the efficiency of electrical body impedance
measurement (BIA) to indicate malnutrition and
to predict clinical outcome of MHD patients.
BIA was performed during a two year-time period
in 126 MHD patients. Twenty-two patients
died during this time period. Forty-six patients
were re-examined at 2 years interval.
The cross sectional analysis of the 126 MHD
patients demonstrated a significant positive correlation
between serum albumin (ALB) and phase
angle (PA), reactance (Xc), body cell mass
(BCM). Age and extra-cellular volume % of total
body water (ECW%) correlated negatively with
ALB. No correlation was found between body
mass index (BMI), or sp Kt/V and ALB. The longitudinal
study of 46 patients demonstrated no
significant variation in ALB and sp Kt/V, a slight,
but statistically significant reduction in BMI
(p<0.05) and a highly significant reduction in PA,
Xc, BCM, while ECW% significantly increased.
Significantly lower values of PA, Xc and BCM
and significantly higher values of ECW% were
found in the 22 patients deceased within 2 years
in comparison with still alive patients, while no
difference was found for ALB and sp Kt/V values.
BMI seems inadequate to assess nutritional
status in MHD. Data derived from BIA (PA, Xc,
BCM and ECW%) are significantly correlated
with ALB, which is a validated marker of malnutrition
in MHD patients. BIA seems even more
sensitive than ALB to predict the risk of death in
MHD patient
Albumin modification and fragmentation in renal disease.
No full textAlbumin is the most important antioxidant substance in plasma and performs many physiological functions. Furthermore, albumin is the major carrier of endogenous molecules and exogenous ligands. This paper reviews the importance of post-translational modifications of albumin and fragments thereof in patients with renal disease. First, current views and controversies on renal handling of proteins, mainly albumin, will be discussed. Post-translational modifications, namely the fragmentation of albumin found with proteomic techniques in nephrotic patients, diabetics, and ESRD patients will be presented and discussed. It is reasonable to hypothesize that proteolytic fragmentation of serum albumin is due to a higher susceptibility to proteases, induced by oxidative stress. The clinical relevance of the fragmentation of albumin has not yet been established. These modifications could affect some physiological functions of albumin and have a patho-physiological role in uremic syndrome. Proteomic analysis of serum allows the identification of over-expressed proteins and can detect post-translational modifications of serum proteins, hitherto hidden, using standard laboratory techniques
Serum levels of intact parathyroid hormone (1-84 PTH) and large related C-terminal fragments (7-84 PTH) in chronic kidney disease patients at different functional stages.
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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