85 research outputs found
Architetture e architetti di Casa Chigi nel primo Rinascimento altolaziale
No full textLa fabbrica del santuario altolaziale di S. Maria della Sughera presso Tolfa venne finanziata dal banchiere senese Agostino Chigi e realizzata fra il 1504 e il 1523 nella forma di una tribuna ottagonale libera avente in asse, nella parte postica, un convento agostiniano. L’argomento è già stato trattato in un volume monografico pubblicato dalla scrivente nel 1998: in esso ha attribuito la paternità del complesso devozionale chigiano a Baldassarre Peruzzi, non senza riserve per alcune peculiarità della grande «cappella» e per la presenza sul cantiere di un architetto minore, Bernardino di Giovanni da Viterbo, più noto come scalpellino-scultore e costruttore. Il presente saggio si è ora proposto d’approfondire la personalità artistica del maestro viterbese per verificare se potesse a lui ascriversi il progetto del santuario tolfetano. È in conclusione apparso probabile che, senza escludere il coinvolgimento del Peruzzi, nel cantiere di Tolfa Bernardino possa aver definito in fase d’esecuzione i dettagli architettonici e costruttivi della Tribuna.
Riassumendo e organizzando gli attuali dati di conoscenza, in mancanza di sue opere architettoniche certe, nel presente contributo si producono riflessioni originali e documenti inediti, utili a proseguire lo studio sull’artista viterbese e sulle sue effettive capacità di architetto. Vagliando la bibliografia già edita sull’architetto viterbese e avvalendosi di nuove ricerche d’archivio, lo studio ha consentito all’autrice di rilevare la presenza dell’architetto e scultore in cantieri dove hanno operato gli architetti Antonio da Sangallo il Giovane e Baldassarre Peruzzi e per il momento solo di ipotizzare, con questi, possibili ripetute collaborazioni. La ricerca ha inoltre permesso di chiarire su basi documentali l’effettivo ruolo di Bernardino da Viterbo nella realizzazione della Chiesa di S. Giovanni degli Almadiani a Viterbo e di proporre la sua identificazione con un omonimo architetto attivo a Ronciglione nel periodo in cui Antonio da Sangallo il Giovane lavorò all’ampliamento farnesiano della città altolaziale. L’identificazione, se comprovata, aggiungerebbe un nuovo tassello di conoscenza della variegata attività di Bernardino.
Allegandolo in 'Appendice' al presente contributo, N. Mannino ha inoltre elaborato il primo regesto biografico ragionato sull’architetto viterbese. Ne emerge una figura di artista, architetto e tecnico dalle molteplici capacità, che entra a buon diritto nel panorama storico-artistico del Rinascimento romano e laziale.Santa Maria della Sughera near Tolfa, financed by the banker from Siena Agostino Chigi, was built in the shape of an octagonal tribuna. In a previous monographic contribution the author attributed the complex to Baldassare Peruzzi, but not without reservations due to several unique characteristics of the large “chapel” and the presence of a less famous architect on the worksite: Bernardino di Giovanni da Viterbo, better known as a chiseller-sculptor and builder. The paper reviews the personality of the maestro from Viterbo to verify whether the design of the sanctuary could be his. Without excluding the fact that Peruzzi did work on the sanctuary, Bernardino probably designed the architectural and building details of the tribuna during its construction. Without the comfort of certified architectural works, and based on current data, the paper discusses and presents original ideas and unpublished documents which can be used in further studies about Bernardino di Giovanni. By screening the bibliography already published on Bernardino and making use of new research in archives, the study allowed the Author to notice the presence of the Architect and Sculptor from Viterbo in building yards where worked the architects Antonio da Sangallo the Younger and Baldassare Peruzzi and for the moment only to suppose possible, repeated collaborations with the same personages. The research also clarified on documentary bases the actual role of Bernardino da Viterbo in the construction of the church of S. Giovanni degli Almadiani in Viterbo and led to propose his identification with a namesake architect active in Ronciglione in the period in which Antonio da Sangallo the Younger worked for the expansion of this city in Northern Lazio on behalf of the Farnese Family. The identification, if ascertained, would add a new element to the knowledge of the varied activities of Bernardino.
The Author has elaborated the first reasoned biographical Regesto on the Architect of Viterbo and has enclosed it in form of Appendix to such essay published. What emerges is the personality of an artist, architect and multi-capable engineer, which enters rightfully in the art-historical landscape of Renaissance of Rome and Lazio
Profiles of sulfonylurea use in Diabetes Mellitus type 2: an analysis of clinical practice over the last 10 years
No full textAims: Describing the evolution over time in the use of sulfonylureas (SUs) and the characteristics of patients at first prescription and at interruption of treatment with SUs. Methods: Retrospective evaluation of data from the Italian Association of Diabetologists (AMD) Annals registry (2010-2020), about T2D patients who started treatment with SUs. The longitudinal probability of remaining on SUs was estimated by Kaplan Meier survival curves. Results: SU prescription decreased from 30.7 % (2010) to 12.9 % (2020). Patients started on SU were 68.2 ± 11.2 years old, mostly males (55.5 %), with diabetes duration = 10.1 ± 8.3 years, BMI = 29.7 ± 5.5 kg/m2, and HbA1c = 8.3 ± 1.7 % [67 mmol/mol]. After one year, the probability of staying on SU was 85.4 %, 75.9 % after two years, 68.2 % after 3 years, 56.6 % after 5 years. Patients who discontinued SUs had higher BMI and HbA1c, were younger, more often males and treated with insulin. Over time, the percentage of subjects switched to metformin, DPP4i, SGLT2i, and GLP1RA increased, whereas use of glinides, glitazones, acarbose and insulin declined. Conclusions: These data suggest a consensus, slowly, but increasingly aligning with the current National indications of dismissing SUs for the treatment of T2D. The new drugs for diabetes should represent a preferable choice in all patients who do not have specific contraindications
Il Carattere e la Costruzione
No full textIl saggio affronta la questione del valore della "costruzione" nel progetto di architettura.
La riflessione è focalizzata sul valore “espressivo" delle forme della costruzione. Si indaga il rapporto tra forme tecniche e forme architettoniche in differenti sistemi costruttivi (tettonici/stereotomici) riconoscendo nel "decoro", proprio della forma architettonica, una intenzionalità rappresentativa dei principi di "costruzione". Utilizzando la categoria del "decoro" si analizzano le sintassi e le "forme identificatrici" degli elementi del linguaggio architettonico corrispondenti a differenti principi di costruzione. Si descrivono successivamente i caratteri delle forme e i caratteri degli spazi riferirti a differenti "idee di costruzione". La parte finale del saggio è dedicata alla trattazione del rapporto di "appropriatezza" da istituire tra caratteri della costruzione e caratteri dell'edificio.The paper faces the matter of the value of the "Construction" in the project of architecture.
The reflection is focused on the "expressive" value of constructive forms. The author investigates the relationship between technical forms and architectural forms in different constructive systems (tectonic vs stereotomic) recognizing in the "decorum", proper of the architectural forms, the intentionality of represent the principles of "construction." The author analyses the syntaxes and the “forms” identifying the elements of the architectural language (basing on different principles of construction), using the category of the "decorum". Subsequently are described the characters of the forms and the characters of the spaces reported to different "ideas of construction." The final part of the paper treats the concept of "appropriateness" analysing the relationship between characters of the construction and characters of the building
Prepregnancy BMI influences maternal and fetal outcomes in women with isolated gestational hyperglycaemia: a multicentre study
No full textAIM:
This multicentre study analyzed the maternal and fetal outcomes of women who had one elevated 3-h oral glucose tolerance test (isolated gestational hyperglycaemia [IGH]).
METHODS:
From 1999 to 2003, data were collected for 606 IGH women from 31 Italian obstetric or diabetic centres, including time and mode of delivery, gestational hypertension, preeclampsia, eclampsia, congenital malformations, and neonatal mortality and morbidity, to compare them with the general pregnant Italian population. A prognostic model for the outcome of pregnancy was constructed, and the concurrence of certain specified conditions was considered a positive outcome, whereas pregnancies that failed to meet one or more of the stated conditions were classified as "complicated".
RESULTS:
Macrosomia was significantly more frequent in women with IGH than in the normal pregnant population (10.7 vs 7.4%, respectively; P=0.003). Stillbirth and neonatal mortality rates did not differ from those in normal pregnancies, while a slight rise in the frequency of major malformations was not statistically significant (1.48 vs 0.89%, respectively; P<0.11). Multivariate logistic analyses confirmed that the prepregnancy body mass index (BMI) was an independent predictor of a complicated pregnancy. As for fetal growth, multivariate logistic analyses according to BMI showed that being overweight or obese were strong predictors of macrosomia.
CONCLUSION:
These findings in a large cohort of Italian women with IGH confirm the detrimental effect of even minimally altered glucose tolerance on fetal outcome. Also, prepregnancy obesity plays an important role in raising the risk of adverse perinatal outcomes in such patients
INVESTIGATION ON OLD-GROWTH FORESTS OF SICILY: PRELIMINARY RESULTS
No full textOld-growth forests are natural forests that have developed over a long period of time, without experiencing severe, stand-replacing disturbance a fire, windstorm, or logging. According to UNEP/CBD/SBSTTA definition, an old-growth forest is a primary or a secondary forest which has achieved an age at which structure and species normally associated with old primary forests of that type have sufficiently accumulated to act as a forest ecosystem distinct from any younger age class. In a thematic contribution to the National Biodiversity Strategy, the authors report the following definition of Italian old-growth forests: Forest in which human disturbance is absent or negligible, and in which natural dynamics create a mosaic of all the forest regeneration phases, including the senescing one. Such phase is characterized by large old trees, deadwood (snags logs and coarse woody debris) and a vascular plant species composition that is consistent with the biogeographical
context and includes highly specialized taxa related to the small-scale disturbance and the
microhabitats resulting from structural heterogeneity. In Sicily, 472 hectare were recognized as old-growth forests mainly distributed in Regional Natural Parks, Reserves, Site of Community Importance (SCI) and, Special Protected Areas (SPA). In particular, 18 forest areas, located over 1000 m of altitude and characterized by high
index of woodiness, were surveyed in the provinces of Caltanissetta, Catania, Messina and Palermo. In the frame of a research project granted by the University of Palermo, an investigation was carried out in the “Bosco Pomieri”, an old-growth forest included in the Madonie Park (N.-Sicily). In 2013, a multidisciplinary research team started to analyse vascular plant and the cryptogamic diversity, and also carrying out some plant physiology tests and an environmental monitoring. The “Bosco Pomieri” is a mixed oak wood characterized by the presence
of many old trees of Quercus petraea (Matt.) Liebl. subsp. austrothyrrenica Brullo, Guarino & Siracusa and a dense
shrub layer with Ilex aquifolium L. In the forest area we also find Fagus sylvatica L., Acer pseudoplatanus L., A.obtusatum W. & K., Ulmus glabra Huds., Sorbus torminalis L., Malus sylvestris (L.) Mill., and, sporadically, Quercus cerris
L. and Q. pubescens s.l. Shrubby species, such as Daphne laureola L., Crataegus laciniata Ucria, Ruscus aculeatus L. and,
Rhamnus catharticus L., are also present in the investigated area (5, 6). Preliminary results of the investigation
carried out in the “Bosco Pomieri” are here reported. At present, 9 benthic algal taxa of algae belonging to the
Divisions Cyanophyta, Rhodophyta, Chlorophyta, and Bacillariophyta are currently listed. 74 lichens, mainly epiphytic, belonging to the genera Caloplaca Th. Fr., Lecanora Ach., Physcia (Schreb.) Michx. and Ramalina Ach. Fungi are currently represented by 62 saprotrophic, parasitic and mycorrhizal species
La flora e la vegetazione sommersa del porto di Cala Santa Maria nell'isola di Ustica (Pa): contributo allo Studio di Impatto Ambientale (S.I.A.)
No full textUse of insulin detemir in pregnancy: a report on 10 type 1 diabetic women
No full textSomalia has suffered a massive internal population displacement and exodus that began in 1988 and is still ongoing during the prolonged and intermittent civil war. This review looks at the burden of HIV infection in Somali and the impact of civil war on its epidemiology. Serosurveys have indicated that HIV was not present in Somalia before the civil war and to date Somalia has had an HIV prevalence markedly below that of its neighbours. However, due to the ongoing war HIV sentinel surveillance cannot reach most of the affected areas in Somalia and the current HIV infection problem may be greater than the figures indicate
Factors Associated with Primary Liver Cancer Survival in a Southern Italian Setting in a Changing Epidemiological Scenario
No full textA retrospective observational study utilising cancer incidence data from a population-based registry investigated determinants affecting primary liver cancer survival in a southern Italian region with high hepatitis viral infection rates and obesity prevalence. Among 2687 patients diagnosed between 2006 and 2019 (65.3% male), a flexible hazard-based regression model revealed factors influencing 5-year survival rates. High deprivation levels [HR = 1.41 (95%CI = 1.15–1.76); p < 0.001], poor access to care [HR = 1.99 (95%IC = 1.70–2.35); p < 0.0001], age between 65 and 75 [HR = 1.48 (95%IC = 1.09–2.01); p < 0.05] or >75 [HR = 2.21 (95%CI = 1.62–3.01); p < 0.0001] and residing in non-urban areas [HR = 1.35 (95%CI = 1.08–1.69); p < 0.01] were associated with poorer survival estimates. While deprivation appeared to be a risk factor for primary liver cancer patients residing within the urban area, the geographic distance from specialised treatment centres emerged as a potential determinant of lower survival estimates for residents in the non-urban areas. After balancing the groups of easy and poor access to care using a propensity score approach, poor access to care and a lower socioeconomic status resulted in potentially having a negative impact on primary liver cancer survival, particularly among urban residents. We emphasise the need to interoperate cancer registries with other data sources and to deploy innovative digital solutions to improve cancer prevention.Statistic
IL "TORMENTATO" CAMMINO DEL CONCORSO ESTERNO IN ASSOCIAZIONE MAFIOSA TRA INCESSANTE TRAVAGLIO GIURISPRUDENZIALE E PERDURANTE AFASIA LEGISLATIVA
No full textL’obbiettivo della presente tesi è quello di ripercorrere il «tormentato» cammino del concorso esterno in associazione mafiosa, seguendone l’itinerario cronologico.
L’indagine prenderà le mosse dall’evoluzione storica del paradigma criminoso dell’associazione di stampo mafioso, onde porre in risalto le ragioni politico-criminali sottese alla genesi della fattispecie destinata a reprimere i sodalizi mafiosi. Ci soffermeremo sui principali nodi dogmatico interpretativi dell’art 416 bis c.p. con riferimento sia alla composizione strutturale, sia ai suoi limiti di estensione, cercando di bilanciare in maniera equilibrata teoria e prassi.
Successivamente, si guarderà all’evoluzione giurisprudenziale del concorso esterno nel reato associativo: istituto che ha attraversato le soglie delle Sezioni Unite della Cassazione con una frequenza sconosciuta financo ai più controversi istituti del nostro diritto penale. Si avvicendano così la Sentenza Demitry nel 1994, la prima sentenza Mannino nel 1995, la Sentenza Carnevale nel 2002, e infine la seconda sentenza Mannino nel 2005: nomi «divenuti familiari per indicare un travaglio di lunga durata, talvolta focalizzato su aspetti specifici della questione, ma per lo più incentrati su una sola questione ricorrente: limiti e condizioni di rilevanza della condotta di compartecipazione eventuale al reato associativo» .
Si proseguirà con l’analisi della sentenza della Corte europea dei diritti dell’uomo nel caso Contrada, la quale sembra aver scoperchiato un vero e proprio «vaso di pandora», mettendoci definitivamente di fronte alla coesistenza, non sempre armoniosa, di due diversi paradigmi di legalità esistenti a livello nazionale ed europeo.
La sentenza Contrada e il suo difficile recepimento all’interno del nostro ordinamento offriranno poi lo spunto per una ricognizione dei vari strumenti fin qui adoperati dalla giurisprudenza interna, la quale, come vedremo, si è arrovellata nella ricerca di rimedi processuali idonei a garantire l’esecuzione delle sentenze europee in ossequio ai dicta della Corte di Strasburgo. L’indagine analizzerà, inoltre, la vexata quaestio inerente l’estensibilità o meno erga alios del decisum Contrada, anche a favore di quei soggetti – definiti “fratelli minori” – che, sebbene non abbiano adito la Corte europea si siano trovati nella medesima situazione sostanziale di quella giustiziata a Strasburgo.
In conclusione, si cercherà di profilare, in prospettiva de lege ferenda, un itinerario logico cui potrebbe ispirarsi l’ormai ineludibile riforma legislativa del settore, cercando di mediare tra esigenze repressive da una parte e rispetto dei principi costituzionali dall’altra
re-/ Can Poetry Hold Us All?: A Journey Out of Trauma-Based Writing
No full textThesis (Master's)--University of Washington, 2025re- and the accompanying essay "Can Poetry Hold Us All?: A Journey Out of Trauma- Based Writing" explore the complex relationship between trauma, creativity, and recovery through a poetic and reflective lens. It chronicles the author’s journey from writing that was deeply entrenched in personal trauma to a re-imagined creative practice grounded in healing, presence, and self-renewal. Initially trapped in cycles of repetition and emotional exhaustion, the author confronts the limitations and mental toll of trauma-based writing. Through intentional disengagement from past themes and the development of new coping mechanisms, the author begins a process of creative re-discovery. The resulting poetry collection, re-, deliberately omits contextual details and instead emphasizes the emotional and thematic aftershocks of experience—loss, uncertainty, and hope—allowing readers to engage freely and empathetically. Influenced by experimental poetics, the gothic tradition, and writers such as Aase Berg, Orlando White, and Ross Gay, the work prioritizes fluidity, ambiguity, and the power of the present. The thesis is ultimately a testament to the ability to re-build a sustainable and life-affirming writing practice, one that moves with—and not against—the self
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