177,646 research outputs found
Testi di evangelizzazione nel medioevo germanico: il modello del "Pater noster"
No full textAtti a cura di V. Dolcetti Corazza, R. Genr
Telomere/telomerase interplay in virus-driven and virus-independent lymphomagenesis: pathogenic and clinical implications
No full textTelomerase is a ribonucleoprotein complex critically involved in extending and maintaining telomeres. Unlike the majority of somatic cells, in which hTERT and telomerase activity are generally silent, normal lymphocytes show transient physiological hTERT expression and telomerase activity according to their differentiation/activation status. During lymphomagenesis, induction of persistent telomerase expression and activity may occur before or after telomere shortening, as a consequence of the different mechanisms through which transforming factors/agents may activate telomerase. Available data indicate that the timing of telomerase activation may allow the distinction of two different lymphomagenetic models: (i) an early activation of telomerase via exogenous regulators of hTERT, along with an increased lymphocyte growth and a subsequent selection of cells with increased transforming potential may characterize several virus-related lymphoid malignancies; (ii) a progressive shortening of telomeres, leading to genetic instability which favors a subsequent activation of telomerase via endogenous regulators may occur in most virus-unrelated lymphoid tumors. These models may have clinically relevant implications, particularly for the tailoring of therapeutic strategies targeting telomerase
Infectious etiopathogenesis of extranodal lymphomas
No full textSeveral infectious agents are established causes of non-Hodgkin’s lymphoma in humans. They include human immunodeficiency virus (HIV), Epstein-Barr virus (EBV), human herpes virus 8 (HHV-8), hepatitis C virus (HCV), and Helicobacter pylori. In addition, a causal role is suspected for hepatitis B virus (HBV), Borrelia burgdorferi, Campylobacter jejuni, and various Chlamydia species. For some of these agents, notably HIV, HHV-8, H. pylori, Chlamydia, and B. burgdorferi, the association seems specific to one or a few types of extra - nodal lymphomas, while EBV is associated with a variety of nodal and extranodal lymphomas. In the case of HCV, the risk of both nodal and extranodal lymphomas seems increased among chronically infected individuals. No data are available on HBV and risk of extranodal lymphoma. In the following sections, the epidemiological and pathogenetic evidence linking infectious agents to extra - nodal lymphoma is reviewed. Infectious agents may contribute to lymphomagenesis by two main pathogenetic mechanisms. First, a direct role is played mainly by viruses such as EBV and HHV-8, which infect target cells and express a variety of viral products that promote cell growth and survival. Additional environmental and genetic factors contribute to the malignant phenotype. The virus genome is usually present in all tumor cells. Secondly, infectious agents, mainly bacteria, may indirectly contribute to lymphomagenesis by providing a chronic antigenic stimulus that would drive the development of extranodal lymphomas along a continuum pathway, starting from the development of acquired mucosaassociated lymphoid tissue (MALT), through low-grade lymphoma, and ultimately leading to high-grade tumors. Proliferation of B cells may be dependent on the contact with infiltrating antigen-specific CD4+ helper T cells. Antigens derived from the infectious agent may be cross-reactive with self-antigens, which, in turn, may further sustain B cell growth. This model indicates that infectious agents could trigger autoimmune reactivity and emphasizes the likely relevant role of autoimmune mechanisms in the pathogenesis of some extranodal lymphomas (Figure 4.1). © 2008 by Taylor & Francis Group, LLC
Le simbolizzazioni affettive sul contesto quale medium per la formazione: il caso di un laboratorio per psicologi.
No full textIl contributo descrive ipotesi e tipo di processo formativo utilizzati entro un laboratorio di una facoltà di psicologia. Il laboratorio intendeva formare all'utilizzo dell'Analisi Emozionale del Testo una metodologia di ricerca funzionale all'intervento psicologico clinico su gruppi, organizzazioni e istituzioni
Il laboratorio di statistica per l’analisi del testo: pensare le emozionai attraverso il testo.
No full textIl lavoro articola una proposta sul modo di fare formazione attraverso un laboratorio a studenti di psicologia. Il laboratorio è quello di statistica per l'analisi del testo. Nella formazione è stato implicato il processo emozionale condiviso dagli studenti allo scopo di facilitare la trasformazione di quelle categorie di pensiero utili alla professione
GSK-3 beta inhibition - At the crossroad between Akt and mTOR constitutive activation to enhance cyclin D1 protein stability in mantle cell lymphoma
No full textStrategies able to downregulate the aberrant expression of cyclin D1 may prove of therapeutic relevance in cancer patients. This is particularly true for mantle cell lymphoma (MCL) in which cyclin D1 is overexpressed as a consequence of the t(11;14)(q13;q32) translocation. We have recently demonstrated that an increased cyclin D1 stability also contributes to the high levels of this protein observed in MCL cells. This effect is mediated by a constitutive activation of PI3-K/Akt, which keeps GSK-3β inhibited. Here we show that inhibition of PI3-K/Akt induces a 40% decrease of cyclin D1 half-life as a result of accumulation of the dephosphorylated/active form of GSK-3β within the nucleus, where this kinase can phosphorylate cyclin D1 on Thr286 thereby promoting its nuclear export. Translocation of cyclin D1 into the cytoplasm is mediated by the nuclear exportin CRM1, whose association with cyclin D1 increases following PI3-K/Akt inhibition. Notably, rapamycin downregulated GSK-3β Ser9 phosphorylation with concurrent nuclear export of cyclin D1 only in MCL cells in which GSK-3β is under the control of mTOR. These findings suggest that the ability to downregulate cyclin D1 through GSK-3β may identify subsets of MCL patients who may benefit from the treatment with mTOR inhibitors and stimulate further studies to assess whether the inability to affect GSK-3β activity may constitute a clinically relevant resistance factor to mTOR inhibitors. ©2008 Landes Bioscience
La condivisione della sicurezza: un intervento con l'Analisi Emozionale del Testo
No full textL'abstract presenta di un intervento realizzato allo scopo di condividere una cultura della sicurezza presso gli studenti di un gruppo scuole umbre. E' stata realizzata una conoscenza della cultura degli studenti con l'Analisi Emozionale del Testo (AET) dalla quale sono scaturiti gli indicatori di sviluppo su cui si è lavorato
Riflessi germanici delle funzioni pastorali indoeuropee
No full textNella preistoria indoeuropea alcune le funzioni gerarchiche sono rappresentate anche attraverso i tre diversi ambiti pastorali. In questo lavoro si mette in evidenza come anche l'area germanica permette di evidenziare attraverso alcuni testi letterari la specificità di tali aspetti gerarchici che nella figura del guardiano di porci si relazionano con il potere regale
Emozioni e cambiamento organizzativo
No full textE' presentato un caso di intervento organizzativo in cui il cambiamento della cultura locale, rispetto a delle problematiche di funzionamento di un gruppo di lavoro, è stata il focus di una ricerca-intervento condotta usando l'Analisi Emozionale del Testo (AET)
- …
