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    PHARMACEUTICAL STANDARDIZATION OF PANCHAGUNA TAILA (MEDICATED OIL) AND PRODUCT DEVELOPMENT AS OINTMENT, GEL, CREAM, AND PHYSIOWAX

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      Objective: The present study aimed to prepare Panchaguna taila (PGT) and its development in various dosage forms, i.e. ointment, gel, cream, and physiowax to exemplify the characteristic parameters according to pharmaceutical standards.Methods: PGT is polyherbal medicated oil used externally for treating wounds, cut, and burn and used for massaging in rheumatoid arthritis, muscular pain, sprains, and joints pain. Prepare the decoction using Haritaki, Vibhitaki, Amalaki, Nimba, Sambhalu and prepare paste (kalka) from Madhuchishta, Gandhaphiroja, Shilarasa, Rala, and Guggulu. Mix all the ingredients and heat till watery portion not evaporated from the oil with constant stirring then filter it. Add eucalyptus oil, turpentine oil, and kejoputi oil at the end and stir it well. Prepare various dosage forms like ointment, gel, cream, and physiowax using suitable base for the better and improved therapeutic application. Analytical standards for PGT such as acid value, saponification value, iodine value, and peroxide value were performed, and obtained results were appeared under the prescribed limit of the official monograph. Various physicochemical parameters such as homogeneity, spreadability, pH, and melting point were performed for PGT ointment, PGT gel, PGT cream, and PGT physiowax. Stability study of PGT was done for 3 days under the accelerated conditions.Results: In PGT, various physicochemical parameters were performed on the interval of 24, 48, and 72 hrs, and no significant variation found in their physicochemical properties when observed values were compared. PGT ointment, PGT gel, PGT cream, and PGT physiowax containing PGT as active pharmaceutical ingredient with various suitable excipients and base are easy to formulate and convenient to apply over the affected area. Rf observed between the ranges 0.21 to 0.84 as given in the standard monograph. In PGT, PGT ointment and PGT physiowax, 10 spots were found, and in PGT gel and PGT cream, 7 spots were found. 0.11, 0.15, and 0.34 spots were found in the PGT gel, PGT cream, and PGT physiowax, respectively, that can be given by the excipients or base used for their preparation.Conclusion: It is possible to make other dosage form of PGT which can be more convenient to the customers. Hence, the issues related to the PGT like staining and sticking can be resolved by developing or converting the PGT into various convenient dosages.</jats:p

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    IMPACT OF FERMENTING AGENTS ON MARKETED PATENT PROPRIETARY FORMULATION ASHWAGANDHA KALPA

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      Objective: The present work is aimed to formulate Ashwagandha kalpa and evaluate the impact of fermenting agent.Methods: A. kalpa is a marketed patent proprietary Ayurvedic product prepared by adopting the Ayurvedic principles of madya sandhana and it belongs to the class of formulations known as Sandhana kalpana. It is given to the patients suffering from hypertension, insomnia, paralysis, loss of concentration, etc. In the preparation of madya sandhana, the sandhana dravya (fermenting agents) play a key role. The present study was taken up to see the effect of three different sandhana dravya (fermenting agents), i.e., Dhataki pushpa (DAK), Madhuka (MAK), and yeast (YAK) on the formulation characterization of A. kalpa.Results: The prepared samples were tested for their physicochemical parameters, i.e., total solid, pH, specific gravity, sugar content, alcohol content, refractive index, phytochemical screening, quantitative assay for secondary metabolites, and high-performance thin-layer chromatography (HPTLC) fingerprinting. The findings of phytochemical evaluation, quantitative assay, and HPTLC fingerprint show marked variation among three different prepared samples of A. kalpa. The preliminary phytochemical estimation for the detection of secondary metabolites was done. The study revealed the presence of highest percentage of alkaloids in YAK, tannins in DAK and saponins in YAK. Total solid content was found to the highest in MAK. Physicochemical parameters such as pH, total solid content, refractive index, alcohol content, and specific gravity also showed marked variation. Alcohol content for the DAK and YAK was found same.Conclusion: sandhana dravya (fermenting agent) causes variations in different physicochemical and phytochemical parameters in the formulation and development of A. kalpa.</jats:p

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis

    Dispelling the Myths Behind First-author Citation Counts

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    We conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more sophisticated methods

    Author Index

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    koamabayili/VECTRON-author-checklist: VECTRON author checklist

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    We have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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