1,721,223 research outputs found
Progression-free survival as a surrogate endpoint of overall survival in patients with metastatic colorectal cancer
Full text linkBackground: In many clinical trials designed to assess the efficacy of anticancer treatments, overall
survival (OS) is often used as a primary endpoint despite its several points of weakness.
Methods: This study evaluated the role of progression-free survival (PFS) in the first three
lines of treatment as a potential surrogate endpoint of OS in patients with metastatic colorectal
cancer (MCRC). One hundred and twenty patients with MCRC were enrolled in this study. The
median PFS of the first-, second-, and third-lines of treatment and the OS were evaluated. The
correlation between the time to progression and the OS was analyzed. The median PFS of the
three lines of treatment were 8.5, 5, and 3 months, respectively.
Results: The median OS was 32.4 months. A modest correlation was found between the PFS
to the first-line treatment with Folfox–avastin and OS. Similar data were obtained with the
second-line treatment. However, no correlation was found between the PFS and OS during the
third-line treatment. The regression analysis revealed that PFS is predictive of OS.
Conclusion: In brief, the PFS of the first- and second-lines of treatment could be a good candidate as a surrogate endpoint of OS in patients with MCRC
γδ T cells and their clinical application in colon cancer
No full text: In recent years, research has focused on colorectal cancer to implement modern treatment approaches to improve patient survival. In this new era, γδ T cells constitute a new and promising candidate to treat many types of cancer because of their potent killing activity and their ability to recognize tumor antigens independently of HLA molecules. Here, we focus on the roles that γδ T cells play in antitumor immunity, especially in colorectal cancer. Furthermore, we provide an overview of small-scale clinical trials in patients with colorectal cancer employing either in vivo activation or adoptive transfer of ex vivo expanded γδ T cells and suggest possible combinatorial approaches to treat colon cancer
Vγ9 Vδ2 T lymphocytes activation as a novel approach to test efficacy of different bisphosphonates
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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