1,720,958 research outputs found
Influence of Parmigiano Reggiano diet on male sexual behavior in rats: behavioral and neurochemical study
Full text linkAbstract: The influence of Parmigiano Reggiano (P.R.) cheese on copulatory behavior was studied in male rats.
Sexually naїve, sluggish and potent rats were chronically fed with a diet of P.R. cheese for 10 d. Mount, intromission,
ejaculation latencies and the percentage of mounting and ejaculating animals were recorded during the mating test.
Microdialysis technique was used to detect the extracellular levels of dopamine (DA) and its metabolite
dihydroxyphenylacetic acid (DOPAC) in rat brain following the P.R. diet. The P.R. diet was able to improve sexual
behavior in naїve rats increasing the percentage of mounting and ejaculating animals. Moreover it was able to reduce
latencies of mounts, intromissions and ejaculations and to increase the percentage of mounting and ejaculating animals
in sluggish rats. Finally, in the microdialysis study an increase in DA and its metabolite DOPAC was found in P.R. fed
naїve rats in comparison with control group
Griffonia simplicifolia negatively affects sexual behavior in female rats
No full textAt present Griffonia simplicifolia is used in food supplement aimed to treat mood disorders as well asto reduce food intake and body weight. The plant has gained increasing interest for its high content in5-hydroxy-l-tryptophan (5-HTP) particularly in the seed. The present study was designed to evaluatethe influence of a seed extract of the plant, dosed at 25, 50 and 100 mg/kg, on the sexual behavior ofovariectomized hormone-primed rats after acute and subchronic treatment. The single administrationof G. simplicifolia significantly reduced lordosis response and increased rejection behavior in female ratstreated with the highest dose while it did not influence proceptive behaviors. On the other hand the subchronicadministration of the extract significantly reduced proceptivity but not receptivity, and increasedrejection behavior. All the tested dosages were able to markedly decrease food intake and body weightafter a 9-day treatment. Taken together the present results, possibly ascribed to increased levels of 5-hydroxytryptamine (5-HT) in the brain, suggest a cautious administration of the plant extract owing toits negative influence on female sexual behavior
Increased sexual motivation in female rats treated with Humulus lupulus L. extract
No full textAim of the study: To evaluate the influence of Humulus lupulus extract on sexual behavior in female rats.Materials and Methods: Ovariectomized rats hormonally primed with estradiol benzoate (1.5 μg/rat) and progesterone (500 μg/rat) were acutely treated by oral gavage with Humulus lupulus extract dosed at 5, 10 and 25 mg/kg and then tested for partner preference and sexual receptivity.Results: The administration of Humulus lupulus extract at the highest dose significantly increased the preference for the stimulus male during the partner preference test and the number of proceptive behaviors during the receptivity test, without affecting the lordosis response. Conclusions: Humulus lupulus extract increased sexual motivation in hormone-primed female rats
Discovery of a new 5-HT1A receptor agonist, acting ‘in vivo’ in a rat model of anxiety and depression
No full textNot availabl
Quantitative analysis of acetylcholine in rat brain microdialysates by liquid chromatography coupled with electrospray ionization tandem mass spectrometry
No full textA liquid chromatography tandem mass spectrometry (LC/MS/MS) method has been developed for the quantitative analysis of acetylcholine in rat brain dialysates. The separation of acetylcholine (ACh), choline (Ch), acetyl-β-methylcholine (IS) from endogenous compounds and Ringer's salts was achieved with cation exchange chromatography. Optimization of chromatographic and mass spectrometry parameters were perfomed in order to improve sensitivity of the method. The limit of detection were 0.05 and 3.75 fmol on column with S/N ratio of 3:1 for ACh and Ch, respectively. The limit of quantitation (LOQ) for ACh and Ch measured in Ringer's solution were 0.05 nM (0.25 fmol) and 3.75 nM (18.75 fmol), respectively at S/N ratio of 10:1. Linearity of the method has been evaluated in the concentrations range between 0.05 and 5.00 nM and 3.75 and 200 nM for ACh and Ch respectively. The correlation coefficients were 0.999 and 0.995 for ACh and Ch respectively, indicating very good linearity. The LC/MS/MS method developed has been applied to evaluate the effect of oral administration of 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (IDRA21), a positive modulators of AMPA receptor, on the release of ACh in the rat prefrontal cortex by microdialysis
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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