1,721,089 research outputs found
Infrastrutture-attive: Ripensare il design urbano per una mobilità sostenibile e città rinaturalizzate
No full textIn the contemporary era, cities face complex urbanisation, climate change, and environmental impact reduction challenges. In this context, conventional urban infrastructures evolve into ‘active infrastructures,’ designed to dynamically interact with the environment, improve quality of life, and promote sustainability. Unlike traditional, active infrastructures adapt to environmental, social, and economic changes through advanced technologies, innovative materials, and ecological design. A key example is sustainable mobility, which includes electric and hybrid public transport, bright bike lanes, and sharing systems integrated with IoT and artificial intelligence. These solutions reduce the environmental impact of urban transport and promote accessibility.
Another essential dimension is urban renaturation, which reintegrates natural elements into city spaces, creating hybrid ecosystems and improving climate resilience. Interventions such as linear parks, waterway rehabilitation, and green roofs support biodiversity and promote social and psychological well-being. The synergy between sustainable mobility and urban renaturation represents an opportunity to design multifunctional infrastructures that meet complex needs in densely populated contexts. Despite the challenges of cost and technical complexity, the long-term benefits of urban resilience, reduced emissions, and quality of life make these solutions a strategic investment. This article analyses how active infrastructure, combining sustainable mobility and renaturation, can transform cities into more liveable, resilient, and inclusive spaces, defining a new frontier for future urban design
Use of phage display technique for identifying peptides capable of binding progenitor/stem cells, peptides thereby obtained and uses thereof
No full textThe present application relates to the utilization of phage display technique, based on phage libraries of random sequence type or with defined amino acid sequences for identifying peptide sequences capable of binding human progenitor/stem cells, as well as peptides and derivatives thereof identified and isolated by such methods. The present invention further relates to methods of recognizing, monitoring and modifying progenitor/stem cells by use of complexes comprising said peptides and derivatives
Nutrients: The environmental regulation of cardiovascular gene expression
Full text linkThe complexity of nutrient-gene interactions has led to the development of a new branch in the nutrition sciences, the nutrigenomics. The individual susceptibility to nutrients based on environment → genotype → phenotype interplay makes this new research field extremely promising although complex. In this review, we highlight and examine recent findings and the most relevant hypotheses on the role of the diet in the onset and progression of cardiovascular diseases. The effect of unbalanced diets on the cardiovascular system is considered one of the most important risk factors both for ischemic and degenerative myocardial pathologies. The concept that nutrigenomics could help in improving public and personal health is becoming tangible indicating future directions for basic and applied research in the pathophysiology of cardiovascular disease. © Springer-Verlag 2007
Alveolar particulate guanylate cyclase stimulation by atrial natriuretic factor in the cardiomyopathic hamster lung: cytochemical demonstration.
No full textPost-buckling behaviour of thermoplastic matrix composite laminates subjected to pure shear
No full textThe present study focuses on the determination of the buckling load and post-buckling behaviour of simply supported laminated composite rectangular panels loaded in shear. The nonlinear structural response is studied with a non-linear finite element approach. In order to determine the accuracy of the procedure, several tests have been performed comparing the finite element solutions for isotropic and laminated composite rectangular panels with existing ones, adopting different sequences of lamination and different length to width ratios. The analysis then considers the behaviour of laminates produced with innovative thermoplastic matrix composites developed in the frame of a national research program
Harnessing inorganic nanoparticles to direct macrophage polarization for skeletal muscle regeneration
Full text linkModulation of macrophage plasticity is emerging as a successful strategy in tissue engineering (TE) to control the immune response elicited by the implanted material. Indeed, one major determinant of success in regenerating tissues and organs is to achieve the correct balance between immune pro-inflammatory and pro-resolution players. In recent years, nanoparticle-mediated macrophage polarization towards the pro-or anti-inflammatory subtypes is gaining increasing interest in the biomedical field. In TE, despite significant progress in the use of nanomaterials, the full potential of nanoparticles as effective immunomodulators has not yet been completely realized. This work discusses the contribution that nanotechnology gives to TE applications, helping native or synthetic scaffolds to direct macrophage polarization; here, three bioactive metallic and ceramic nanoparticles (gold, titanium oxide, and cerium oxide nanoparticles) are proposed as potential valuable tools to trigger skeletal muscle regeneration
Turning regenerative technologies into treatment to repair myocardial injuries
Full text linkRegenerative therapies including stem cell treatments hold promise to allow curing patients affected by severe cardiac muscle diseases. However, the clinical efficacy of stem cell therapy remains elusive, so far. The two key roadblocks that still need to be overcome are the poor cell engraftment into the injured myocardium and the limited knowledge of the ideal mixture of bioactive factors to be locally delivered for restoring heart function. Thus, therapeutic strategies for cardiac repair are directed to increase the retention and functional integration of transplanted cells in the damaged myocardium or to enhance the endogenous repair mechanisms through cell-free therapies. In this context, biomaterial-based technologies and tissue engineering approaches have the potential to dramatically impact cardiac translational medicine. This review intends to offer some consideration on the cell-based and cell-free cardiac therapies, their limitations and the possible future developments
Harnessing Inorganic Nanoparticles to Direct Macrophage Polarization for Skeletal Muscle Regeneration
Full text linkModulation of macrophage plasticity is emerging as a successful strategy in tissue engineering (TE) to control the immune response elicited by the implanted material. Indeed, one major determinant of success in regenerating tissues and organs is to achieve the correct balance between immune pro-inflammatory and pro-resolution players. In recent years, nanoparticle-mediated macrophage polarization towards the pro- or anti-inflammatory subtypes is gaining increasing interest in the biomedical field. In TE, despite significant progress in the use of nanomaterials, the full potential of nanoparticles as effective immunomodulators has not yet been completely realized. This work discusses the contribution that nanotechnology gives to TE applications, helping native or synthetic scaffolds to direct macrophage polarization; here, three bioactive metallic and ceramic nanoparticles (gold, titanium oxide, and cerium oxide nanoparticles) are proposed as potential valuable tools to trigger skeletal muscle regeneration
Atrial natriuretic factor (ANF) and ANF receptor C gene expression and localization in the respiratory system: effects induced by hypoxia and hemodynamic overload.
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