1,721,106 research outputs found
Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment.
No full textROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions, for the treatment of which, the use of antioxidants was proposed.
Over time, it was shown that ROS at low concentrations act as signaling molecules leading to the regulation of physiological functions. Moreover, several interventions that increase ROS generation activate stress-adaptive responses that extend the lifespan. It was also shown that excessive use of antioxidants can counter the beneficial effects of ROS.
Currently, much progress has been made in understanding the role of ROS in human diseases and aging as well as in the regulation of physiological functions, and in identifying the signaling pathways involved in ROS. However, much remains to be understood about the mutual interactions among signaling pathways underlying organism-adaptive responses, their modifications (which occur during aging), and some disease states. The aim of this special issue is underlines the effects of ROS production and antioxidant treatment in living organisms, focusing on their impact on health, diseases, and aging
Effect of myocardial ischemia and reperfusion on mitochondrial function and susceptibility to oxidative stress
No full textPhysiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment 2.0
No full textH2O2 production and response to stress conditions by mitochondrial fractions from rat liver
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Effect of thyroid state on rate and sites of H2O2 production in rat skeletal muscle mitochondria
No full textEffect of thyroid state on H2O2 production by rat heart mitochondria: sites of production with complex I and complex II- linked substrates
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Effect of thyroid state on rate and sites of H2O2 production in rat skeletal muscle mitochondria
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