1,721,593 research outputs found
Six months of omeprazole 20 mg daily, 20 mg every other day or 40 mg at weekends in duodenal ulcer patients: A multicenter, prospective, comparative study
No full textWe performed an open, prospective, randomized, three-cell, 6-month clinical trial on the prevention of duodenal ulcer (DU) relapse, comparing three ome-prazole schedules, i.e. 20 mg daily, 20 mg every other day (e.o.d.) and 40 mg on Saturdays and Sundays (S/S). Diagnosis of either healed or relapsed DU was on an endoscopic basis. Follow-up visits were performed at 3-monthly intervals with endoscopy at the baseline, after 6 months and at every symp tomatic relapse. Statistics: Ï2 test with standardized deviates, Yatesâ corrected Ï2 test and analysis of variance (one-way). One hundred and fifteen patients were randomized to receive omeprazole 20 mg/day, 123 omeprazole 20 mg e.o.d. and 115 40 mg S/S. Twenty-eight dropped out (11, 8 and 9, respectively). Demonstrated ulcer relapse rates were 5.7% with omeprazole 20 mg/day, 18.1% with 20 mg e.o.d. and 17.6% with 40 mgS/S (p = 0.0124, âper-protocolâ analysis). No clinically significant adverse effects were recorded. In conclu sion, of the three schedules studied, omeprazole 20 mg/day proved the most effective maintenance treatment for healed DU. © 1995 S. Karger AG, Basel
Gastric ulcer, epithelial dysplasia, and the development of cancer in the elderly patient
No full textPrevalence of Helicobacter pylori infection and clinical efficiency of serological investigation
No full textBackground; Helicobacter pylori has been associated with various gastroduodenal diseases, in particular chronic type B gastritis. It is also an important risk factor for peptic ulcer and gastric carcinoma. Methods; In this study we ascertained: a) the prevalence of H. pylori infection in patients submitted to endoscopy with biopsy, and b) the clinical efficiency of the measurement of immunoglobulin G antibody to H. pylori (HELORI test) compared with the golden standard (histology) and the urease test. Results: Overall, at histology 300 out of 432 patients (10%) were positive for H. pylori; of these 300, 244 were also positive at serology. The prevalence of H. pylori infection was higher in subjects over 60 years of age. On the contrary, no specific antibodies were found in 81 out of 132 patients who at histology were negative for N. pylori. The sensitivity, specificity, and overall efficiency of serology were 84%, 64% and 75%, respectively. The clinical efficiency of serology was higher when agreement between the results of at least two of the three diagnostic tests for H. pylori was used as the reference value for comparison studies. Only 20% of H. pylori-positive subjects were found to have normal gastric mucosa at endoscopy and histology. On the other hand, in these patients a high prevalence of duodenal ulcer and chronic gastritis was found. Conclusions: We demonstrated a significant prevalence of infection from H. pylori in our population of patients with gastrointestinal disease. The clinical efficiency of serology is quite satisfactory, in particular using as reference value the concordance of at least two diagnostic tests for H. pylori
Autumn meeting of Interdisciplinary Group for Ulcer Study (G.I.S.U.) on the use of nizatidine in gastric ulcer. Firenze, 17 October 1992. Introduction
No full text
Helicobacter pylori and Serum Pepsinogen A, Pepsinogen C, and Gastrin: A Methodological Note
No full textSerum pepsinogen I levels and HLA-B22: A genetic association in a subgroup of duodenal ulcer patients
No full text
The risk of gastric dysplasia in medical long-term treatment of peptic ulcer disease.
No full textThere have been recent findings of gastric cancer in patients treated with cimetidine but too soon after treatment for that drug to have had a pathogenetic role. Ranitidine has been shown to induce slight changes in the gastric mucosa. In 117 patients with gastric ulcer followed-up in some cases for 24 months, five cases of cancer were detected, one after more than a year of follow-up. The numbers were too small to allow any conclusion to be drawn regarding relationships with medication. No significant differences in incidence of gastric epithelial dysplasia between control patients and patients treated with cimetidine or ranitidine were found. No dysplastic lesions were seen during a brief follow-up of 19 duodenal ulcer patients and a few gastric ulcer patients treated with pirenzepine but the data is too limited to allow conclusions to be drawn
STUDIO DELL'IMMUNITA UMORALE E DELLA FUNZIONE GASTRICA IN SOGGETTI CON VITILIGINE
No full textA clinical, biohumoral and immunological study of gastric function was carried out in 31 subjects with a view to evaluating the incidence of the association of pathological alterations, subjective disturbances and modifications in humoral disturbances and modifications in humoral immunity during the condition, which many workers consider to have immunitary pathogenesis. The results obtained suggest that in 50% of cases, vitiligo is associated with various pathological alterations and subjective disturbances. Disease associations and biohumoral and immunological alterations are more frequent in patients with hypergastrinaemia and/or circulating auto antibodies, but at the present time there are no certain factors supporting an immunological pathogenesis
- …
