1,721,106 research outputs found
Therapeutic use of hyaluronic acid fillers in the treatment of corticosteroid-induced skin and subcutaneous atrophy
No full textCorticosteroid injection–related tissue atrophy might
cause permanent skin and soft tissue deformities1
due to several factors, most importantly fibroblast
inhibition and decreased Type I collagen synthesis.
Correction of these deformities is challenging and is
mostly based on volume replacement with lipofilling
or other methods.
Clinical observations and research have shown that
injection of stabilized hyaluronic acid (HA) induces collagen
synthesis, partially restoring dermal matrix components,
and eventually producing a permanent effect.2–5
Based on these data, we hypothesize that HA injections
might successfully treat atrophic tissue changes
caused by corticosteroid injection.
We describe a case of persistent buttock corticosteroid
injection–related skin and soft tissue atrophy treated
successfully with repeated HA injections
Nonsurgical treatment of earlobe aging in Mowlavi stages I and II earlobe ptosis with Hyaluronic acid fillers
No full textBackground: Earlobe deflation caused by fat atrophy is normally treated with lipofilling, mostly in the context of facelift surgery. In this report, we aim at reporting on Hyaluronic Acid injections to treat earlobe deflation. Materials and Methods: 16 Mowlavi Grade I and II patients were treated with HA injections, followed by molding to shape the lobule. Results: Effective correction, lasting 14 months on average, is achieved. Five patients needed a touch-up procedure after 4-6 months to improve the result. Conclusions: Earlobe augmentation with HA is an ideal option for correction of earlobe atrophy in cases of Mowlavi Grades I and II ptosis. Long-lasting (about 14 months) correction is achieved with no downtime
Hyaluronic acid-based two-stage medical therapy to unfold the aged face: The centrifugal approach
No full textBackground: Facial aging is a multifactorial process characterized by structural changes to the dermis and ligaments, lipoatrophy in the fat pads and hypodermis, remodeling of the bony skeleton, change in muscle tonicity and tissue descent. Aims: The purpose of this study is to evaluate the efficacy of a hyaluronic acid-based treatment for the aging face that addresses all its causes in a caudal to cranial and medial to lateral direction: the centrifugal technique. Methods: Between March 2015 and January 2018, 187 patients were treated with a high G’ hyaluronic acid in two sessions, one/two weeks apart, to improve signs of facial aging, starting from the lower centrofacial area and progressing laterally and cranially. Results were assessed using a Global Aesthetic Improvement Scale (GAIS) judging pre- and post-treatment (32 weeks) pictures. Results: The technique effectively treated the aging face. The investigator and all patients evaluated the results improved or very much improved and agreed that the results were very natural looking. Conclusion: Use of a systematic centrifugal technique to address the signs of facial aging resulted in significant and long-lasting improvement, as judged by the investigator and high patient acceptance and satisfaction
Rare prostatic carcinomas: histogenesis and morphologic pattern.
No full textMost prostate cancers (90%) are acinar adenocarcinomas originating in the peripheral or other prostatic regions. The pathological finding, clinical course and immunohistochemical studies, indicate that the small cell carcinoma of the prostate is most likely to be a neuroendocrine neoplasm
Cheek volumization and the nasolabial fold
No full textSir: We have read the article by Mowlds and Lambros1
with great interest and enthusiasm. The findings
of their study show that the nasolabial fold does not
improve after cheek injection.
By analyzing three-dimensional images of the face
before and immediately after cheek injection of high-
G′ hyaluronic acid, they demonstrate that the perceived
nasolabial fold improvement, reported after cheek
injections,2,3 is attributable to overall improvement in
facial appearance rather than to actual nasolabial fold
improvement. As a consequence, it might be ruled out
that the nasolabial fold is a consequence of cheek deflating
and it is likely attributable predominantly to change
in the corner of the mouth and to muscular traction.4
This finding is of paramount importance because
cheek overvolumization is frequently performed in an
attempt to achieve something that will not occur: correction
of the nasolabial folds. This practice is responsible
for the bloated, overfilled appearance of the
cheeks. Cheek overfilling gives a bulging, unnatural
result, especially on animation.
Increasing cheek volume and enhancing malar
projection, by injecting the deep medial cheek fat
compartment, is part of the treatment because lost
volumes should be replaced.5 It is overfilling in an
attempt to improve nasolabial and nasojugal folds that
causes unnatural results. In fact, we see more and more
patients asking to avoid that overfilled appearance. We
also strongly agree with the authors’ statement that
“young faces benefit from filling prominences and
older faces benefit from filling hollows.”
We would like to emphasize how important it is to
fill the nasolabial fold and nasojugal crease directly in
the subdermal plane as they become hollow with age.
The benefit of treating these areas is clearly shown
by the case presented (Figs. 1 and 2). The result is
obtained progressively (in two sessions separated by 10
days) using LP–nonanimal stabilized hyaluronic acid
gel (Restylane Perlane, now Lyft, Restylane; Q-Med,
Uppsala, Sweden). The result is long lasting and can
be maintained by yearly repeated injections (Fig. 2).
Treating the nasolabial and nasojugal creases
directly allows not only elimination of the crease but also
maintenance of a natural result by avoiding overfilling
of the cheek. We aim at supporting the breakthrough
findings of Mowlds and Lambros that volumizing the
cheek does not improve the nasolabial fold. Filling of
the cheek must be performed judiciously to reshape
the cheek, and any attempt at treating the nasolabial
fold by volumizing the cheek will fail. To flatten the
nasolabial fold, it should be directly injected
Revealing the role of past and current climate in shaping the distribution of two parapatric European bats, Myotis daubentonii and M. capaccinii
Full text linkNucleolar organizer regions in malignant melanoma and melanocytic nevi. Comparison of two counting methods.
No full textUsing a silver staining technique, we studied nucleolar organizer regions (AgNOR) in paraffin sections of junctional nevi, compound nevi, intradermal nevi, blue nevi, dysplastic nevi, Spitz nevi, lentigo maligna, malignant melanomas in nevus, superficial spreading melanomas, and nodular melanomas. Two methods of counting black dots within nuclei were employed. One method was to count the discrete black dots within the nuclei, including the tiny black dots seen within the nucleolus; the second method did not take into account the subsidary cluster of tiny black dots seen within the nucleolus, instead treating these dots as a single structure. Whichever method we used, a significant difference was found between the pooled mean AgNOR numbers for benign and malignant lesions. We found an overlap, however, between benign, in particular Spitz and dysplastic nevi, and malignant lesions when considering individual counts of AgNOR using both methods. We conclude that studying AgNOR does not seem to be a useful technique to differentiate Spitz and dysplastic nevi from malignant melanomas
Influence of interface properties on mechanical behaviour of a particle reinforced metal matrix composite
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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