1,721,051 research outputs found
Neonatal seizures: relation of Ictal Video-electroencephalography (EEG) findings with neurodevelopmental outcome.
No full textNeonatal electroencephalographic background activity has been
found to be a predictive factor of the neurodevelopmental outcome.
The aim of our study was to identify if the electrical ictal
findings present on the first electroencephalography (EEG)
recording are related to the outcome of newborns with neonatal
seizures. The study is based on the prospective evaluation of
newborns consecutively admitted to the Neonatal Intensive
Care Unit at the University of Parma between September 2001
and September 2004. Thirty-eight subjects were enrolled in the
study on the basis of the following inclusion criteria: presence
on the first EEG of at least 1 seizure, neurodevelopmental
follow-up until 18 months of corrected age, and performance
of several ultrasound brain scans during the neonatal period and
of at least 1 cerebral MRI within the first year of life. For
each seizure, the following were considered: onset topography,
morphology of the epileptiform discharges, spread of the discharge,
number of electrographic regions of seizure onset,
number of seizures per hour, duration of the seizures, and the
Ictal Fraction (= total duration of the seizures/duration of the
EEG recording × hour). At the last follow-up, the unfavorable
neurodevelopmental outcome seems significantly related
to the moderate/severe background activity abnormalities (p =
.006), to the spread of ictal discharge to the contralateral hemisphere
(p = .02), and to the Ictal Fraction, when it exceeds 10
minutes (p = .036). In conclusion, the analysis of the propagation
of the ictal discharge and of the Ictal Fraction might suggest
significant prognostic information since the first hours of life
First comes the A, then the B: what we learned from the COVID-19 outbreak
No full textThe SARS-CoV-2 epidemic, which has spread to many countries around the world, has hit Europe particularly hard. From our point of view, in a rural emergency department (with an annual patient census of around 25,000) in northeastern Italy, it is necessary to preserve the hospital and prevent it from becoming an outbreak of infection. In our experience, we reevaluated the negative predictive value of lung ultrasound to rule out lung involvement. Since severe acute respiratory failure appears to be the leading cause of death for COVID-19 patients, it is essential to focus on this clinical feature. We currently believe that a patient suspected of COVID-19, if he has a normal ultrasound examination (a so-called "A-profile"), can be discharged home to continue isolation and be treated without being hospitalized
Integrating intraoral, perioral, and facial scans into the design of digital dentures
No full textDigital technologies offer the opportunity to integrate facial scans into the design of digital dentures and provide a beneficial 3D preview and simulation of the tooth arrangement for both treatment planning and communication. The presented technique describes a procedure of merging and aligning the intraoral scans of edentulous arches, the scans of the perioral area, and the scan of the nose made by using an intraoral scanner, as well as facial scans made by using a mobile phone. Thus, a digital patient can be obtained and used to optimize individual tooth arrangement during the design of the digital denture
The Impact of Point-of-Care Ultrasound on the Diagnosis and Management of Small Bowel Obstruction in the Emergency Department: A Retrospective Observational Single-Center Study
Full text linkBackground and Objectives: Small bowel obstruction (SBO) requires prompt diagnosis and management. Due to its advantages, POCUS can be beneficial when assessing SBO. However, it is still doubtful whether POCUS performed by an emergency doctor can prolong the time of patients with SBO in the emergency department (ED). The primary outcome was time to diagnosis when using POCUS compared to not using it. Secondary outcomes included the processing time in the ED, ED length of stay (LOS), rates of abdominal radiography, hospital LOS, and mortality. Materials and Methods: We conducted a retrospective, observational study in our ED from 1 November 2021 to 31 December 2023, including patients aged 18 and older diagnosed with SBO. Both groups received confirmation of their diagnosis through contrast-enhanced computed tomography. The two groups of patients (POCUS group vs. non-POCUS group) were compared regarding the time needed to reach the final diagnosis (i.e., time to diagnosis), the ED LOS, the hospital LOS, and in-hospital mortality. Results: A total of 106 patients were included. The median time to diagnosis was 121 min for the POCUS group vs. 217 min for the non-POCUS group (p < 0.001). Median ED processing time was 276 min in the POCUS group compared to 376 min in the non-POCUS group (p = 0.006). ED LOS was also shorter in the POCUS group (333 vs. 436 min, p = 0.010). Abdominal X-ray rates were lower in the POCUS group (49% vs. 78%, p = 0.004). Hospital LOS was similar between the two groups (p = 1.000). Five non-POCUS patients died during hospitalization; none died in the POCUS group, but the difference was not statistically significant (p = 0.063). Conclusions: POCUS significantly reduced time to diagnosis and ED LOS. Further exploration is needed to assess long-term outcomes and the cost-effectiveness of integrating POCUS into ED practice
Effects of cyclosporin on intimal hyperplasia in an experimental model histomorphometric study
No full textRegression of thymoma-induced lichenoid hypersensitivity reactions of the oral mucosa following thymoma treatment: a case report
No full textThymomas are neoplasms associated with paraneoplastic disorders. Severe hypersensitivity reactions involving the oral cavity may be the first sign of an undiagnosed thymoma. Oral manifestations of an underlying thymoma may present as recurrent severe painful lesions with associated significant morbidity, often not responding to standard therapeutic measures. This case report describes the treatment of a 75-year-old woman who presented with severe oral lichenoid hypersensitivity reactions secondary to an undiagnosed underlying thymoma. No substantial improvement of the oral conditions was achieved with conventional therapies (topical and systemic steroids); however, almost complete resolution of the lesions was achieved following completion of radiation therapy for the thymic neoplasm. This article is intended to serve as a resource for clinicians to understand early, rare manifestations of an undiagnosed thymoma
Three Dimensional Printed Surgical Guides: Effect of Time on Dimensional Stability
No full textPurpose: To analyze, in vitro, the dimensional stability over time of 3D-printed surgical guides.Materials and methods: Ten surgical guides, manufactured by digital light processing 3D-printing technology, were scanned immediately after post-processing and then after 5, 10, 15, and 20 days. The corresponding standard tessellation language (STL) files were used for comparison with the reference CAD project. Mean absolute deviation (MAD) of the intaglio surface, axial, and linear deviations of the sleeves' housings were measured. Generalized estimated equations models (alpha = 0.05) were used to investigate the effect of time.Results: MAD of the teeth intaglio surface showed less variation (minimum: 0.002, maximum: 0.014 mm) than that of the mucosa (minimum: 0.026, maximum: 0.074 mm). Axial variations of the sleeves' housings on the sagittal (minimum: - 0.008 degrees, maximum: -0.577 degrees) and frontal plane (minimum: -0.193 degrees, maximum: 0.525 degrees) changed with similar patterns, but opposite trends (decreasing for the former). Linear deviations of center points of the sleeves' housings had a shifting (minimum: -0.074, maximum: 0.02 mm) pattern with a decreasing tendency. Time after processing had a significant effect, either alone or nested with guides volume, on all outcomes of interest, except for MAD of the mucosa intaglio surface (p < 0.001), which was significantly affected only by the time-volume nested effect (p = 0.012).Conclusions: Within the limitations of the experimental design, postmanufacturing dimensional variations of surgical guides were statistically significant. Although limited, they are an additional source of variability affecting the overall accuracy of computer-guided surgery. As such, they should be addressed by further research
Effects of cyclosporin on intimal hyperplasia in an experimental model: Preliminary results
No full textManagement of oral leukoplakia in patients with Fanconi anemia
Full text linkFanconi anemia (FA) is a rare genetic disease involving an increased risk of developing acute myeloid leukemia and solid tumors, especially head-and-neck squamous cell carcinomas, for which the oral cavity is the most frequent site of occurrence. The patient presented in this study underwent allogeneic hematopoietic stem cell transplantation (HSCT) and developed nonhomogeneous oral leukoplakia after 7 years, which was promptly removed and diagnosed with high-grade epithelial dysplasia. Many risk conditions for oral squamous cell carcinoma were featured in the present case including FA, allogeneic HSCT, graft-versus-host disease, immunosuppressive therapy, female gender, nonsmoker, tongue location and nonhomogeneous type of leukoplakia. Close follow-up of the entire upper aerodigestive tract mucosa and early removal of all suspected lesions are highly recommended in the management of such patients
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