283 research outputs found
LEİSHMANİAZİSLİ KÖPEKLERDE ÜRİNER 8- HİDROKSİDEOKSİGUANOZİN İLE OKSİDATİF DNA HASARININ İNCELENMESİ
No full textLEİSHMANİAZİSLİ KÖPEKLERDE ÜRİNER 8-HİDROKSİDEOKSİGUANOZİN İLE OKSİDATİF DNA HASARININ İNCELENMESİ
Derya D. Aydın Adnan Menderes Üniversitesi, Sağlık Bilimleri Enstitüsü, Veterinerlik İç Hastalıkları Programı, Yüksek Lisans Tezi, Aydın, 2025.
Amaç: Canine Visceral Leishmaniazis’li (CVL) köpeklerde üriner 8-hidroksideoksiguanozin (8-OHdG) düzeyleri ile oksidatif DNA hasarının belirlenmesi amaçlandı.
Gereç ve Yöntem: Çalışma kapsamında rutin klinik değerlendirmede tanı almış 40 leishmaniazisli ve 20 sağlıklı olmak üzere toplam 60 köpek ele alındı. Çalışmaya dahil edilen köpeklerde idrar 8-OHdG düzeyleri ile serum TAS, TOS ve MDA düzeyleri ELISA yöntemiyle ölçüldü.
Bulgular: Her iki grup arasında yaş, ırk (saf ve melez) ve cinsiyet açısından benzer dağılım gösterdi. Enfekte köpeklerde sistemik bulgulardan lenfadenopati, dermatolojik bulgulardan kepeklenme en sık görülen lezyonlar arasındaydı. Oksidatif parametrelerden TAS, TOS ve MDA enfekte köpeklerde daha yüksek seyrederken, bu artış MDA düzeylerinde sağlıklılara kıyasla anlamlı (p > 0,05) bulunmadı. Benzer şekilde DNA hasar belirteci olan üriner 8-OHdG düzeyleri de enfekte grupta ortalama 1043,79 ± 78,96 pg/ml ile sağlıklarda belirlenen 918,79 ± 105,76 pg/ml değere göre yüksek olmasına rağmen istatiksel fark (p > 0,05) kaydedilmedi.
Sonuç: CVL’li köpeklerde serum TAS ve TOS anlamlı şekilde artarken, üriner 8-OHdG ve serum MDA düzeylerinde anlamlı fark gözlemlenmedi. Bulgular, oksidatif stresin belirgin olduğunu ancak DNA hasarı göstergelerinin sınırlı tanısal değere sahip olabileceğini göstermektedir.
Anahtar kelimeler: Biyobelirteç, Canine visceral leishmaniazis, DNA hasarı, Oksidatif stres, Üriner 8-hidroksi-2'-deoksiguanozinin.KABUL VE ONAY …………...………………………..…………….…….…………... i
TEŞEKKÜR ……………………………………………………………...……………… ii
İÇİNDEKİLER ..…………………………………………….………...…..…….……… iii
SİMGELER VE KISALTMALAR DİZİNİ …..………………...….…………….…….. v
ŞEKİLLER DİZİNİ ….………….…………………………..………...………………….. vii
RESİMLER DİZİNİ……………………………………………………………………….. viii
TABLOLAR DİZİNİ …………….…………………………...……………………............
ix
ÖZET ………………………………………………………………………………............
x
ABSTRACT ………………………………………………………………….…….............
xi
1. GİRİŞ …………………….…………………...……………………….….…..…............
1
2. GENEL BİLGİLER ……………………..…………………………………....…............
2
2.1. Etiyoloji………………………………………………………………………………
2
2.2. Prevalans ………….……...……….………………………………….…......................
4
2.3. Patogenez……………………….……………………………………………...............
6
2.4 Klinik Bulgular………………………………………………………………………… 8
2.5 Tanı…………………………………………………………………………………….. 10
2.6 Canin Visseral Leishmaniazis’te Oksidatif Stres…………………………..………….. 11
2.7 Canin Visseral Leishmaniazis’te Mitokondriyal DNA Hasarı……….…..……............. 15
2.7.1 8-Hidroksideoksiguanozin (8-OHdG)…………………………………..…………… 15
3. GEREÇ VE YÖNTEM……...…………………………………….…..………………… 18
3.1. Gereç………………………………………………………….....…...………................ 18
3.1.1. Kullanılan Cihaz ve Materyaller……….………………..….........….…….................. 18
3.1.2. Hayvan Materyali ………………………..………………..…..….…………………. 18
3.1.3 Etik Değerlendirme………………………………………………………………….. 19
3.2 Yöntem………………………………………………………………………………... 20
3.2.1 Tanı Ve Ayırıcı Tanı………………………………………………………………… 20
3.2.2 Örnekleme İşlemleri………………………………………………………………… 20
3.2.2.1 Kan Örneklerinin Toplanması…………………………………………………….. 20
3.2.2.2 İdrar Örneklerinin Toplanması……………………………………………………. 20
3.2.3 Laboratuvar Analizleri………………………………………………………………. 21
3.2.3.1 İdrarda 8-OHdG Tayini…………………………………………………………… 21
3.2.3.2 MDA, TAS ve TOS Ölçümü……………………………………………………… 21
3.2.4 İstatistiksel Değerlendirme………………………………………………………….. 22
4. BULGULAR…………………………………………………………………………… 23
4.1 Klinik Bulgular………………………………………………………………………... 23
4.2. Üriner 8-OHdG ve Reaktif Oksijen Türleri (TAS, TOS, MDA)…………………….. 25
5. TARTIŞMA…………………………………………………………………………….. 26
6. SONUÇ VE ÖNERİLER……………………………………………………………….. 34
KAYNAKLAR……………………………………………………………………………. 35
EKLER……………………………………………………………………………………. 42
EK 1 (ADÜ - HADYEK)…………………………………………………………………. 42
BİLİMSEL ETİK BEYANI……………………………………………………………….. 43
ÖZ GEÇMİŞ………………………………………………………………………………. 4
Essays on monetary economics
No full textIn my dissertation, I attempt to shed new light on the impact of central bank behavior. The first chapter proposes indexes of monetary policy design characteristics in line with inflation targeting (IT). Indexes aim to provide a useful classification of central banks and to examine whether IT intensity matters for sacrifice ratio and inflation persistence. Results show that U.S. and Japan are ranked close to early targeters. Armenian central bank is detected to perform remarkably well as opposed to the literature's descriptions. Noteworthy structural changes are noticed in Mexico and Peru. Higher index level significantly reduces OECD countries' inflation persistence through increased transparency. Higher intensity among targeters does not deliver significantly lower sacrifice ratio or inflation persistence. Announcing official targets does not provide additional benefits. Low degree of central bank discretion and limited financing of the government significantly decrease the sacrifice ratio among OECD countries and in the full cross-sectional sample respectively. Institutional design features need to be mature enough in order to benefit from inflation targeting. The second chapter examines the usefulness of monetary aggregates. A number of dynamic stochastic general equilibrium models (DSGE) and econometric time series models are jointly specified; including vector autoregressive (VAR), random walk (RW), and various autoregressive (AR) and AR with exogenous variable type models (ARX). Model performance is evaluated via novel testing methods developed for assessing predictive and simulation accuracy. Money is found to matter for inflation simulation purposes in simple econometric models, such as ARX models. With regard to predictive point and density analysis, when complex models are examined, M2 enters into the forecast-best VAR-type inflation models. Model selection is found to be sensitive to researcher’s objective function, to target variable and forecast horizon. Particularly, when the objective is policy analysis, the examination of multivariate models show that DSGE-type models often outperform at longer horizons and mainly for output forecasts. In contrast, VAR-type models win for simulation purposes and short-horizon inflation forecasts. However, univariate models without money generally dominate theoretical and atheoretical multivariate models both with and without money from both forecasting and simulation standpoint.Ph. D.Includes bibliographical referencesIncludes vitaby Demet Tunal
65 yaş ve üstü kullanıcıların fizyolojik, psikolojik ve sosyo-ekonomik gereksinimlerine göre yaşlı yurtları tasarlama kriterlerinin belirlenmesi ve Diyarbakır merkez Huzurevi'nde irdelenmesi
No full textYaşlanma, yaşam sürecinin doğal bir dönemidir. Yaşamın bu evresinde fizyolojik, psikolojik ve sosyo-ekonomik gereksinimlerde değişimler meydana gelmektedir. Yaşlılar için yapılacak yaşlı yurtlarının, bu değişimler göz önüne alınarak tasarlanması gerekmektedir. 65 yaş ve üstü kullanıcıların fizyolojik, psikolojik ve sosyo-ekonomik gereksinimlerine göre yaşlı yurtları tasarlama kriterlerinin belirlenmesi ile, edinilen bilgiler doğrultusunda çalışma alanındaki problemler saptanmıştır. Bu problemin giderilmesini amaçlayan çalışma sekiz bölümden oluşmaktadır. Birinci bölümde; çalışmanın nedeni açıklanarak, sorunun ne olduğu belirtilmiş ve önemi açıklanmıştır. İkinci bölümde; yaşlılık ve yaşlı yurtları ile ilgili, daha önce yapılan yerli ve yabancı çalışmalar incelenmiştir. Üçüncü bölümde; yaşlılık ile ilgili literatürden edinilen bilgiler sunulmuş, yaşlılarla ilgili demografik gelişim incelenmiştir. Yaşlı kullanıcıların fizyolojik, psikolojik ve sosyo ekonomik gereksinimleri ile bunlara bağlı sorunlar araştırılmıştır. Dördüncü bölümde; yaşlı yurtlan ile ilgili kavramlar açıklanmış, yaşlı yurtlan tasarım kriterleri araştırılmıştır. Beşinci bölümde; çalışmada uygulanan yöntem açıklanmıştır. Altıncı bölümde; çalışma alanlan tanıtılmış, yaşlılara düzenlenen anketler değerlendirilmiştir. Yedinci bölümde; yapılan değerlendirmeler sonucu elde edinilen bulgular açıklanmıştır. Bu bulgular yapımı devam eden Diyarbakır Merkez Huzurevi üzerinde irdelenmiştir. Ill Sekizinci bölümde ise çalışmanın sonucu belirtilmiştir. Bu çalışmanın devamında yapılabilecek araştırmalarla ilgili öneriler sunulmuştur. Anahtar Kelimeler: Yaşlılık, Yaşlı Yurdu, Kullanıcı Gereksinimi, Tasarım KriteriAging is a natural period of life process. In this period of life, some changes occur in physiological, psychological and socio-economic requirements. The elderly houses for old people should be designed by taking these changes into consideration. The problems of case study, are determined by examining the design criterions of elderly houses belong to physiological, psychological and socio-economic requirements of 65 years old and over users'. The study, aimed to remove these problems consists of eighth chapters. In the first chapter, the problems of the study were determined by explaining the aim and the importance of the study. In the second chapter, the foreign and native studies about aging and elderly houses that were done before were researched. In the third chapter, the knowledge about aging that was taken from literature was explained and demographic development of elderlys' was examined. Elderly users' physiological, psychological, socio-economic requirements and the problems that depend on these requirements were researched. In the fourth chapter, elderly house concepts were explained and their design criterions were researched. hi the fifth chapter, the method of the study was explained. In the sixth chapter, working areas were introduced and questionnaires were evaluated. In the seventh chapter, the findings that were obtained from the evaluations were explained. These findings were examined in the Central Rest Home of Diyarbakır where its construction is continued. V In the eighth chapter, the results of the study were determined. Some suggestions for future researches were also offered. Key Words: Aging, Elderly Houses, User Requirement, Design Criterio
Evaluation of the ımpact of glycemic control on mean platelet volume and platelet activation in children with type 1 diabetes
No full textObjective: The studies evaluating cases with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) in the adult population reported hyperreactive platelets and increased activation of prothrombotic factors, resulting in an increased risk of thrombosis. The aim of this study was to evaluate the effects of poor glycemic control and the duration of diabetes on platelet parameters in pediatric population. Methods: The study included 366 children, out of which 144 (39.3%) were included in the T1DM group and 222 (60.6%) in the healthy control group. The platelet count, mean platelet volume (MPV), platelet distribution width and plateletcrit values were recorded. The children with T1DM were divided into three groups as per their glycated hemoglobin (HbA1c) levels, good ([removed]9%). Results: No significant difference in the MPV level between the T1DM (7.41 ± 1.49 fl) and control (7.15 ± 1.23 fl) groups was observed. However, the MPV levels were significantly higher in the poor glycemic control group than in the healthy control group (p = 0.026). Furthermore, as the duration of diabetes and HbA1c levels increased, the MPV levels also increased (p < 0.001, p = 0.441). Conclusion: This study suggested as the duration of diabetes and HbA1c levels increased, the MPV levels also increases. Evaluation of hematological parameters can be a cheap and useful method in the evaluation of diabetes regulation in patients with diabetes. © 2022 The Author(s) [2022]. Published by Oxford University Press. All rights reserved
Relationship between arm span and height in postmenopausal osteoporotic women
No full textOsteoporosis is a progressive systemic skeletal disease characterized by low bone density and microarchitectural deterioration of the bone. A minimum 3-cm difference between arm span and height makes up one of the criteria for suspecting osteoporosis. Therefore, it is easy to determine osteoporotic women by measuring the proportion of height to the arm span. The purposes of this study are to assess the relationship between arm span and height and to compare them in postmenopausal and young healthy women. This was a randomized-controlled, prospective study. There were two groups in this study. Group I included 70 postmenopausal osteoporotic women and group II had 70 healthy young women. Height, weight and arm span of the individuals were measured in all subjects. Bone mineral density and radiological examination of spine were also evaluated. Mean age of postmenopausal women was 64.4 +/- 8.6 years and it was 27.3 +/- 3.5 years in young healthy women. Mean height was 152 +/- 5.1 and 161.5 +/- 5.9 cm in group I and II, respectively. Mean arm span length was 159.6 +/- 6.3 cm in postmenopausal women and 163.5 +/- 6 cm in young healthy women. Mean arm span-height difference was significantly higher in postmenopausal women when compared to healthy young women (7.7 +/- 3.6 and 2 +/- 2.9 cm, respectively, P < 0.001). We suggest that arm span measurements can be used in the estimation of youth height and age-related loss in stature in postmenopausal women
Bilateral Brachial Neuritis Following Diphtheria, Tetanus and Pertussis Vaccination: Case Report
No full textBrachial plexopathy in children is commonly caused by obstetrical complications. Only few cases were reported as brachial neuritis which is also known as Personage Turner disease. Antecedent infection, viral diseases, trauma, surgery, and immunization may be the possible etiologic factors causing brachial neuritis. In this case report, a 6 months old child who was referred to our outpatient clinic with bilateral hand, arm and shoulder weakness which occurred after immunization with diphtheria, tetanus and pertussis (DTP) vaccine at 5 months of age is presented. The case was diagnosed as bilateral brachial neuritis according to clinical and electrophysiological data and no possible etiologic factors could be associated with the clinical condition except DTP vaccination
Synthesis and Characterization of Hydroxyapatite Powders From Eggshell For Functional Biomedical Application
No full textBulus, Erdi (Arel Author), İsmik, Deniz (Arel Author), Mansuroğlu, Demet Sezgin (Arel Author), Şahin, Yeşim Müge (Arel Author)Apatitic phosphates are considered within the category of bioceramics. HA and its derives are used of in the fields of medicine, orthopedics and dentistry in order to support a grow up of new bone cells. HA structures have a high biocompability and are widely in biomedical applications. On the other hand, synthesis of HA structures necessitates complex technologies (microwave sintering, hydrothermal synthesis etc.) and their production costs high. This study aims the production of nano apatitic structures with great biocompability from a natural material. Simple hotplate method was used to obtain natural, nano scale HA from eggshells. After calcination and sintering processes at different temperatures, the obtained apatitic phosphate powders have been structurally characterized by infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). Morphological investigation has been conducted by FEG-SEM images. Biological investigations have been carried out for the produced nanosized bioceramics and the results reveal that these nanomaterials are promising for tissue engineering purposes
Short-Term Effects of Interferential Currents on Chronic Myofascial Pain Syndrome
No full textObjective: Myofascial pain syndrome (MPS) is a local or regional pain syndrome that causes chronic muscle pain characterized by the presence of trigger points. Standard treatment includes oral medicines, injections, physical therapy modalities and exercises. The aim of this study was to investigate the short-term effects of interferential current, which is a physical treatment modality, on chronic myofascial pain syndrome. Materials and Methods: In this prospective, randomized-controlled study, we included 40 patients with back pain due to chronic myofascial pain syndrome. The patients were divided into two groups. The first group was treated with vacuum and interferential current (VIC) while the second group was given only vacuum treatment (VT). At the same time, range of motion and stretching exercises were suggested as home training. Pain assessment was done at the beginning and on the 15th day of treatment by using a visual analogue scale (VAS) and the disease activity was measured by patients' and physicians' global assessment scale. Mood assessment was performed using the Beck Depression Inventory. Results: The mean age in the VIC and VT groups was 38.2 +/- 13.2 and 48.2 +/- 14.4 years, respectively. There was a statistical difference between before and after treatment VAS scores, and patients' and physicians' global assessment in both groups (p<0.05). Although algometric measurements were statistically significantly improved at the end of the study in group I (p<0.05), those improvements were not observed in group II (p>0.05). The Beck Depression Inventory scores were within normal range in both groups before treatment, however, a significant decrease was found after treatment (p<0.05). Conclusion: Interferential current therapy is an effective treatment method in chronic MPS. When combined with other treatment methods such as exercise, additional benefits may be obtained
EFFECTS OF FOREIGN LANGUAGE KNOWLEDGE TRANSFER AND GENDER ON TEST RESULTS OF UNDERLINING
No full textAraştırmalar üniversiteye yeni katılan öğrencilerin neyi okumaları gerektiğini bilmediklerinden dolayı okuma ödevlerinde zorlandıklarını göstermiştir. Bu çalışma, yabancı dil bilmenin ve cinsiyetin, üniversite öğrencilerinin metin alt çizme üzerine etkisini araştırmayı amaçlamaktadır. Aynı zamanda, bu konuda yüksek ve düşük notlar alan bazı öğrencilerin okuma ve alt çizme konusundaki görüşleri ile kendilerini birer okur olarak nasıl algıladıkları da araştırılmıştır. Bu amaçla, sınav sonuçlarına göre, her iki bölümden toplam 20 öğrenciden görüşme yoluyla nitel veri toplanmıştır. Nicel araştırma yabancı dil bilgisinin açıklamacı metin alt çizme üzerinde anlamlı bir fark yarattığını göstermiştir. Cinsiyet aynı konuda anlamlı bir belirleyici değildir. Nitel bulgular tema kodlaması ile tablolara aktarılmıştır
TÜRKÇENİN İKİNCİ DİL OLARAK ÖĞRETİLDİĞİ BİR ORTAMDA KÜLTÜRÜN YERİ
No full textBu çalışma, İkinci Dil Olarak Türkçe öğrencilerinin kültür kavramını dört farklı boyut bakımından nasıl tanımladıklarını ortaya koymayı amaçlamaktadır. Aynı zamanda bu çalışma, öğrencilerin ders kitapları ve materyallerindeki kültür unsurlarını nasıl değerlendirdiklerini de betimleme amacındadır. Dil ile kültür arasındaki diyalektik bağlantı düşünüldüğünde, ders kitaplarının ve öğretmenler tarafından kullanılan materyallerin bu kültürel ilişkiyi yansıtması gerekir. Bu gereklilik ışığında, 14 farklı ülkeden 17 öğrencinin katıldığı bir nitel çalışma deseni oluşturulmuştur. Bir sormaca ve yarı yapılandırılmış görüşme yoluyla nitel veri toplanmıştır. Çalışmadan elde edilen bulgular öğrencilerin kültürü tanımlarken çoğunlukla kültürün sosyolojik boyutuna gönderme yaptıklarını ortaya koymaktadır. Ayrıca öğrencilerin ders kitaplarına ve materyallere kültür açısından bakışlarında karşıt görüşlerin olduğu ortaya çıkmıştır
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