1,721,205 research outputs found
Rice bran and its main components: potential role in the management of cardiovascular disease risk.
No full textThe prevention of cardiovascular disease
events is related to a complex management of conventional
and non-conventional risk factors. The first approach to
reduce the cardiovascular disease risk is a correct dietary
approach. Rice bran and its main components (Fibres,
unsaturated fatty acids, triterpene alcohols, phytosterols,
tocotrienols, alpha-tocopherol) have demonstrated their
property to improve the plasma lipid pattern of rodents,
rabbits, non-human primates and humans, reducing total
plasma cholesterol and triglyceride concentration and
increasing the high density lipoprotein cholesterol level.
Other potential properties of rice bran components have
been studied both in vitro and in animal models such as
modulation of the pituitary secretion, inhibition of the
gastric acid secretion, antioxidant action and inhibition of
the platelet aggregation. The main aim of this paper is to
review the available data on pharmacology and toxicology
of rice bran and its main components with a particular
attention to those data suggesting a potential efficacy in
reducing the cardiovascular disease risk
Are there mild and serious metabolic syndromes? The need for a graded diagnosis
No full textMetabolic syndrome is an increasingly incident complex metabolic disorder, affecting around 30% of adults in the USA as well as in Europe. In a meta-analysis that evaluated cardiovascular risk associated with the third National Cholesterol Education Program definition of metabolic syndrome in 951 083 patients, metabolic syndrome was associated with a two-fold increase in the risk of coronary heart disease, cerebrovascular disease, all cardiovascular lethal and nonlethal cardiovascular diseases, and a 1.5-fold increase in the risk of all-cause mortality.In this context, the article in this issue of the Journal of Cardiovascular Medicine further stresses the concept that a 'full' metabolic syndrome, including all or almost all its potential components, is associated with an earlier and more serious organ damage, at both cardiac and vascular levels, than the standard definition of metabolic syndrome on the basis of the presence of three out of five components. Moreover, it confirms the central role of waist circumference as the main metabolic syndrome component associated with early organ damage in the enrolled patients, in whom increased waist circumference could be considered as the clinical phenotype of insulin resistance. These data are relevant because they stress the need for a further definition of metabolic syndrome on the basis of its main clinical characteristics (i.e. insulin-resistance/central obesity) and a fix constellation of associated factors (i.e. mild hypertension, atherogenic dyslipidemia) in order to clearly identify those individuals needing a more aggressive diagnostic and therapeutic approach
Change of some oxidative stress parameters after supplementation with whey protein isolate in patients with type 2 diabetes
No full textObjectives: The aim of this study was to evaluate the effects of undenatured whey protein isolate (WPI; ≥92.5%) with a high content of native cysteine (2.7%) and a standardized content of lactoferrin (≥0.7%) on parameters related to oxidative stress and inflammation in individuals with type 2 diabetes mellitus. Methods: We assigned 120 white patients with type 2 diabetes and glycated hemoglobin ≥6.5% to two groups. The patients were supplemented daily with WPI or placebo for 3 mo. After 3 mo, the markers of oxidation (superoxide dismutase, glutathione peroxidase, glutathione, and reduced glutathione-to-oxidized glutathione ratio) and inflammation (high sensitivity C-reactive protein, interleukin-6, tumor necrosis factor -α, malondialdehyde) were significantly lower in the WPI group than in the placebo group (P < 0.05). The WPI group obtained a significant improvement in the lipid profile and a reduction in fasting plasma glucose compared with baseline and placebo (P < 0.05). No variations of body weight, body mass index or circumferences and metalloproteinase-2 and -9, or soluble receptor for advanced glycation end product were recorded in either groups. Conclusion: Supplementation with WPI may be useful in patients with diabetes to control fasting glycemia. Moreover, it can help to improve inflammatory and oxidative stress, which play a crucial role in the development of diabetes complications and also in the progression of other chronic diseases
What herbalists suggest to our diabetic patients in order to improve their glycaemic control? Evaluation of scientific evidences and potential risks.
No full textTwo-year statin therapy does not alter the progression of intima-media thickness in patients with type 2 diabetes without manifest cardio-vascular disease: response to Beishuizen et al.
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Perindopril and candesartan comparative efficacy and safety in type II diabetic hypertensive patients.
No full textPerindopril and Candesartan comparative efficacy and safety in type 2 diabetic hypertensive patients
No full textCardiovascular and cerebrovascular disease risks are almost doubled when the hypertensive patient is
also affected by diabetes mellitus. Lowering of blood pressure markedly decreases the rate of cardiovascular events and renal deterioration in these
patients.1 Recent comparative studies in diabetes
suggest that, for the prevention of cardiovascular events, angiotensin converting (ACE) inhibitors may
be superior to alternative antihypertensive agents, independently of their antihypertensive effec
Female Sexual Dysfunction in Subjects with Type 2 Diabetes Mellitus
No full textThe correlation of female sexual dysfunction (FSD) with the degree of glycemic control, the duration and complications of diabetic disease and cardiovascular risk factors are not so clear. The aim of this study was to assess the prevalence of FSD in a sample of females with type 2 diabetes mellitus (T2DM), and to identify factors involved in its pathogenesis. We enrolled 81 females who have T2DM. We administered the female sexual function index (FSFI), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) questionnaires. We also estimated anthropometric parameters, glyco-metabolic control, comorbidities, autonomic nervous system assessment, some adipocytokines and ongoing therapy. 87% of participants were affected by FSD. There was evidence of an inverse correlation between the total score of the FSFI questionnaire and the mean of the values of HbA1c in the previous years. There was an inverse correlation with the duration of diabetes and homeostasis model assessment of insulin resistance index in participants not affected by FSD. Participants with FSD have a higher prevalence of anxiety (p = 0.043) and participants with depression and ischemic heart disease scored less on the FSFI questionnaire (p = 0.005 and p = 0.010, respectively). Homocysteine and E-selectin values were higher in participants with FSFI (p = 0.002, and p = 0.017, respectively). Most of the enrolled females with T2DM had FSD. Glycemic control, ischemic heart disease, endothelial dysfunction, autonomic neuropathy, and psychological conditions, such as anxiety and depression, seem to have a close correlation with FSD. An early diagnosis of FSD can help to improve not only participants’ quality of life, but also to early identify and treat risk factors related not only to FSD, but also to cardiovascular risk. Therefore, we highly recommend that clinicians have a high index of suspicion for FSD in females with T2DM
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