1,721,072 research outputs found
Protective effects of quercetin/moss extract (homalothecium sericeum hedw.) combination on STZ-induced diabetic rats
No full textDiabetes Mellitus (DM) is the most common chronic endocrine disorder. Although new drugs and administration techniques for diabetes were developed,
the nature of complications that occur chronically and reduce patients’ quality of life have not been entirely determined. In our study, 35 male rats were
used. A single dose of 40 mg/kg streptozotocin was injected intraperitoneal into 28 rats, and a total of five groups were formed. The diabetes model was
performed by applying 40mg/kg STZ and was not established in the subjects in the control and citrate buffer groups with STZ solvent. The quercetin and
moss extract were given by gavage for three weeks. The liver and pancreas tissues were examined by histochemical and immunohistochemical methods.
Ki-67 (proliferation marker), antinuclear factor kappa (NF-κB), and interleukin 6 (IL-6) immunohistochemically staining revealed significant differences
in inflammation and regeneration in the liver and pancreas tissues. In addition, the TUNEL staining method was used to determine apoptosis. Positivity
was significant between the treatment and diabetes groups. It was determined that the agents used as treatment changed serum superoxide dismutase
(SOD), malondialdehyde (MDA), C-peptide, insulin, and glucose levels.BA
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Diagnostic value of IL-8 in the differantiation of infection and colonization in patients with acinetobacter baumannii in lower respiratory tract samples in the intensive care unit
Get PDFTıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Bakteriyoloji Ana Bilim DalıAmaç: Ventilatör ilişkili pnömoni (VİP), geniş spektrumlu antibiyotiklerin yaygın kullanıldığı, mortalitesi oldukça yüksek sağlık bakımı ilişkili enfeksiyonlardan biridir. Acinetobacter baumannii (A. baumannii) ise VİP'in en yaygın etkenlerindendir. VİP'de tanıya yönelik az sayıda ve nonspesifik test vardır. Kolonizasyon tanı esnasında sıklıkla kafa karışıklığına sebep olur. Bu çalışmada enfeksiyon-kolonizasyon ayrımı yaparken A.baumannii patogenezinde önemli olduğu düşünülen interleukin (IL-8)'in distal hava yollarındaki konsantrasyonunun tanı değerinin araştırılması amaçlanmıştır. Gereç ve yöntemler: Çalışmamız prospektif metodolojik tipte bir çalışmadır. Hastanemizin Anestezi ve Reanimasyon YBÜ'de 01.05.2019 ve 31.03.2020 aralığında yatan ve endotrakeal aspirat (ETA) kültüründe A. baumannii üremesi tespit edilen 36 hasta çalışmaya dahil edilmiştir. Hastalardan üremenin tespit edildiği gün ETA ve serum örneği alınarak santrifüj edilmiş ve üstte kalan kısım ayrılarak -80°C'de saklanmıştır. Hastaların demografik ve tıbbi verileri, klinisyen tarafından enfeksiyon mu yoksa kolonizasyon mu kabul edildikleri kaydedilmiştir. Çalışmanın sonunda enzyme linked immunosorbent assay (ELISA) yöntemiyle örneklerin IL-8 konsantrasyonları ölçülmüştür. Enfeksiyon ve kolonizasyon grubunda serum ve ETA IL-8 değerleri istatistiksel olarak kıyaslanmıştır. İstatistiksel anlamlılIk için p<0,05 kabul edilmiştir. Bulgular: Çalışmaya dahil edilen 36 hastanın %38,9 (n=14)'u kadın, %61,1 (n=22)'i erkekti, yaş ortalamaları 71,1±11,7 yıldı. Hastaların %38,9 (n=14)'u kolonizasyon, %61,1(n=22)'i enfeksiyon olarak kabul edilmişti. İki grup kıyaslandığında ETA IL-8 konsantrasyonu enfeksiyon grubunda istatistiksel olarak anlamlı derece yüksek bulundu (p=0,002). Bununla beraber, serum IL-8 konsantrasyonu enfeksiyon grubunda daha yüksek olmasına ragmen istatistiksel olarak anlamsızdı (p=0,305). Sonuç: Serumdakinin aksine ETA veya BAL gibi distal hava yollarından alınan örneklerde IL-8 konsantrasyonu, A. baumannii'nin etken olduğu VİP şüpheli hastalarda enfeksiyonu kolonizasyondan ayırmada yol gösterici olabilir. Kültürden çok daha hızlı sonuç alınabilmesi önemli bir avantajdır. Elde edilen sonuçlar hipotezimizi desteklemekle birlikte, IL-8'in bir eşik değeri olmaması nedeniyle daha fazla çok merkezli, prospektif, çok aşamalı, biyobelirteç temelli çalışmaya ihtiyaç vardır.Objective: Ventilator associated pneumonia (VAP) is one of the healtcare associated infections where broad spectrum antibiotics are widely used and has a high mortality. Acinetobacter baumannii (A. baumannii) is one of the most common causes of VAP. There are few and nonspesific tests for diagnosis in VAP. Colonization often causes head confusing during the diagnosis. In this study, it was aimed to investigate the diagnostic value of interleukin-8 (IL-8) concentration in the distal airways, which is thought to be important in the pathogenesis of A. baumannii while differentiating infection or colonization. Matherial ve methods: Our study is a prospective methodogical study. 36 patients who were hospitalized in the Anesthesia and Reanimation ICU of our hospital between 01.05.2019-31.03.2020 and A. baumannii growht was detected in the endotracheal aspirate culture were included in the study. ETA and serum samples were taken from the patients on the day when the growht was detected, centrifuged and supernatant was seperated and stored at -80ºC. The demographic and medical data of the patients were recorded whether they were considered infection or colonization by the clinician. At the end of the study, IL-8 concentrations of the samples were measured by enzyme linked immunosorbent assay (ELISA) method. Serum and ETA IL-8 values were compared statistically in the infection and colonization groups. For statistical significance p<0,05 was accepted. Results: Of the 36 patients included in the study, 38.9% (n=14) were women, 61.1% (n=22) were men, and their mean age was 71.1±11.7 years. 38.9% (n=14) of the patients were accepted as colonization and 61.1% (n=22) as infection. When the two group compared, ETA IL-8 concentration was found to be statistically significantly higher in the infection group (p=0,002). However, although serum IL-8 concentration was quantitatively higher in the infection group, it was statistically insignificant (p=0,305). Conclusions: Contrary to serum, IL-8 concentration in samples taken from distal airways such as ETA or BAL can be a guide in distinguishing infection from colonization in patient with suspected VAP caused by A. baumannii. It is an important advantage to get results from culture much faster. Although the results obtained support our hypothesis, since IL-8 doesn't have a cut-off value, more multicenter, prospective, multistage, biomarker based studies are needed
Representation of homoseksual individuals in Turkish cinema after 2000
Get PDFCinsellik tarihi kadar eski olan eşcinsellik, toplumdan topluma derecesi farklılık gösterse de sürekli toplumsal yaptırımlarla ve cezalarla baskı altında tutulmuş, ötekileştirilmiştir. Kadın cinselliğinde var olan kontrol altında tutma durumu eşcinsellikte reddedilme biçiminde gelişmiştir. Toplumdan dışlanma ve marjinal sayılarak sistem dışı bırakılma korkusu yaratılarak toplumsal cinsiyet unsuru aracılığıyla "öteki" cinsel kimlikler baskılanmış ve yok sayılmıştır. Bu yapılırken kültür, din ve sınıfsallık kullanılmış ve cinsiyetler tipleştirilmiştir. Sanat üretimi ataerkil iktidar ve egemen sistem etkisi altında kalmaktan kurtulamamış, topluma uyumlu birey olma anlatıları sanat üretimi içerisinde her zaman var olmuştur. 20. y.y. itibariyle yükselen ve iktidarın en önemli kitleye seslenme aracı olarak kullanılan sinema, söz konusu politik ve toplumsal cinsiyetin yeniden üretim sisteminde yer almıştır. Sinemada eşcinselliğin görünür olması ve güldürü unsuru ya da aşağılanan karakter dışında canlandırılması Dünya Eşcinsel Hareketinin ortaya çıkmasıyla paralellik gösterir. Aynı paralellik Türk Sineması ve Türkiye Eşcinsel Hareketi için de geçerlidir. 2000'lı yıllara kadar sadece yan unsur olarak işlenen eşcinsellik son dönem Türk Sinemasında konu eksenli işlenebilmektedir. Sayısal olarak hala Dünya Sinemasına göre oldukça geride olan Türk Sineması'nda az da olsa dikkate değer örnekler verilmeye çalışılmaktadır. Bu çalışmada, 2000 sonrası Türk Sineması'nda içinde eşcinsel karakterlerin yer aldığı 10 film amaca yönelik örneklem yöntemiyle seçilerek çözümlenmiştir. Söz konusu 10 filmde yer alan 12 karakter içerik analizi yönergesi oluşturularak incelenmiştir. Sonuçta, incelenen filmlerde genel olarak eşcinsel karakterlerin iç dünyalarının anlatımının yüzeysel kaldığı ve yeterince temsil edilmedikleri görülmüştür.Even if it ranges from society to society, the homosexuality, as old as sexuality history, has always been suppressed, alienated by social enforcement and by punishments. Domination which already exists in woman sexuality has developed in the way of being refused in homosexuality. "Other" sexual identities have been suppressed and overlooked throughout social gender factor by creating the fear of being outcast and by regarding them as marginal. While doing this, culture, religion and denomination have been used and genders have been typified. Creation of art hasn?t been able to escape from the effect of patriarchal power and dominant system, and the narrative of being an individual fitting into society has always existed in the creation of art. Cinema, which has ascended since 20th century and has been the most important tool of power to address towards society, has taken part in the system of re-creating this political and social gender. Appearance of homosexuality in the cinema and portraying homosexuality except for the comic factor and humiliated character show parallelism with the emergence of World Homosexual Movement. Same parallelism is valid for Turkish Cinema and Turkish Homosexual Movement. Homosexuality, which was used only as a theme until 2000s, has been able to use as a topic in recent Turkish Cinema. Still falling behind World Cinema in terms of the number of examples, Turkish Cinema can provide the audience with the staggering examples in the World Queer Cinema, though. Homosexuality has become an important issue which has been dealt with all over the world. In this study, after 2000, ten films in Turkish Cinema, in which homosexual characters are included, were selected and analyzed by purposeful sampling method. In particular, 12 characters in these 10 films were examined by creating the content analysis instruction. As a result, it has been seen that in the films examined, the expression of inner worlds of homosexual characters is in general superficial and not adequately represented
A dystopic science fiction: Society of spectacle within black mirror tv series
No full textKitle iletişim araçları içinde, çeşitli kodları ve mesajları büyük kitlelere iletme konusunda en etkin araçlardan biri olan televizyon ve televizyon içerikleri, gelişen teknolojinin de etkisiyle internet üzerinden yayıncılığa evrilmektedir. Çeşitli platformların kurulmasıyla birlikte verilmek istenen mesajlar televizyon dizileri yerine internet dizileri ile iletilmeye başlanmaktadır. Bu mesaj ve kodların birçoğu tüketim toplumu, gösteri toplumu ve gösterişçi tüketim gibi kavramların kod ve mesajlarını iletmektedir.
Black Mirror dizisinin içerdiği kod ve mesajlar, araştırmanın temel konusunu oluşturmaktadır. Bu çalışmada Black Mirror dizisinin beş sezonundan birer bölüm göstergebilimsel analiz yöntemiyle incelenmiş olup, bu incelemeler sonucunda Black Mirror dizisinin gösteri, tüketim ve gösterişçiTelevision and television contents, which are one of the most effective means of conveying various codes and messages to large masses, are among the mass media, with the effect of developing technology, it evolves into broadcasting over the internet. With the establishment of various platforms, the messages to be conveyed are started to be transmitted via internet series instead of television series. Many of these messages and codes convey the codes and messages of concepts such as consumer society, spectacle society, and conspicuous consumption.
These codes and messages contained in the Black Mirror series constitute the main subject of this research. In this study, five parts of the Black Mirror series were analyzed by the semiotic analysis method and as a result of these examinations, it has been determined that the Black Mirror series deals with the concepts of spectacl
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