1,720,979 research outputs found
Validation and characterization of novel autoantibody biomarkers for rheumatoid arthritis
No full textnot availabl
Validation and characterization of novel autoantibody biomarkers for rheumatoid arthritis
No full textnot availabl
SCREENING FOR ANTIBODY TARGETS AS NOVEL CANDIDATE BIOMARKERS FOR THE DIAGNOSIS OF ANKYLOSING SPONDYLITIS USING CDNA PHAGE DISPLAY
No full textThe Prevalence of Vertebral Fractures in Spondyloarthropathies: Relation to Disease Characteristics, Bone Mineral Density, Syndesmophytes and History of Back Pain and Trauma
No full textBackground An increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathies (SpA). The prevalence of moderate/severe radiographic vertebral fractures in SpA in daily practice is unknown until imaging of the full spine is available, as most VFs do not present with the clinical signs and symptoms of an acute fracture.
Objectives The primary aim is to investigate the prevalence of VFs in SpA and the relation to clinical disease parameters.
Methods We evaluated the prevalence of VFs (>25% loss in height) on available radiographs of the thoracic and lumbar spine in 390 consecutive SpA patients in daily practice and their association with disease characteristics, bone mineral density (BMD), the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) and history of trauma.
Results Forty-eight patients (12.3%) had a VF, of whom 56.3% were men, 44.7% had multiple VFs, and 93.8% of VFs were located in the thoracic spine. Compared to patients without VF, patients with a VF were older (52.4 vs. 47.3 years, p<0.01, range 25-84 years), had a marginally lower femoral neck T-score (-1.0 vs. -0.7, p=0.06), more peripheral joint disease (4.4 vs. 3.5, p<0.05) and a higher mSASSS (11.8 vs. 7.0, p<0.05). Of patients with a VF, 14.6% had a history of trauma with acute back pain (p<0.01 vs. no VF).
Conclusions Moderate to severe vertebral fractures are found in more than 10% of SpA patients, already from the age of 25 years on. Most VFs are located in the thoracic region, are related to low femoral neck BMD and to stiffening of the spine, and are only in one out of six patients related to trauma history
SCREENING FOR ANTIBODY TARGETS AS NOVEL CANDIDATE BIOMARKERS FOR THE DIAGNOSIS OF ANKYLOSING SPONDYLITIS USING CDNA PHAGE DISPLAY
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The isotype repertoire of antibodies against novel UH-RA peptides in rheumatoid arthritis
No full textBackground: Recently, autoantibodies against novel UH-RA peptides (UH-RA. 1 and UH-RA. 21) were identified as candidate biomarkers for patients with rheumatoid arthritis (RA) who are seronegative for the current diagnostic markers rheumatoid factor and anticitrullinated protein antibodies. Previously, screening for anti-UH-RA autoantibodies was based on measuring the immunoglobulin (Ig) G response. We aimed to investigate whether measurement of other isotypes could improve the performance of diagnostic testing. In addition, assigning the isotype profile might provide valuable information on effector functions of the antibodies. Methods: The isotype profile of antibodies against UH-RA. 1 and UH-RA. 21 was studied. The IgG, IgM, and IgA classes, together with the 4 different IgG subclasses, were determined in 285 patients with RA, 88 rheumatic control subjects, and 90 healthy control subjects. Results: Anti-UH-RA. 1 antibodies were primarily of the IgM isotype and twice as prevalent as IgG (IgG3-dominated) and IgA. RA sensitivity when testing for anti-UH-RA. 1 IgM was shown to be higher than when testing for the IgG isotype: 18 % versus 9 % sensitivity when RA specificity was set to 90 %. Within antibodies against UH-RA. 21, IgG and IgA were more common than IgM. Different anti-UH-RA. 21 IgG subclasses were found, with the highest prevalence found for IgG2. Combined testing for IgG and IgA slightly increased RA sensitivity of UH-RA. 21-specific antibody testing to 27 % compared with solely testing for IgG (23 %). Notably, a higher number of anti-UH-RA. 21 antibody isotypes was related to increased levels of erythrocyte sedimentation rate. Finally, for both antibody responses, the full antibody isotype use was demonstrated in early and seronegative disease. Conclusions: The isotype distribution of anti-UH-RA. 1 and anti-UH-RA. 21 antibodies was successfully outlined, and, for antibodies against UH-RA. 1, we found that isotype-specific testing might have implications for diagnostic testing. The exact mechanisms by which the different antibody isotypes act still have to be unraveled
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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