6,277 research outputs found
Le jubilé de M. Gaston Darboux
No full textLippmann Gabriel, Poincaré Henri, Appell Paul, Lavisse Ernest, Volterra Vito, Belugou Lucie, Picard Émile, Lévy Lucien, Guichard Claude, Darboux Gaston. Le jubilé de M. Gaston Darboux. In: Revue internationale de l'enseignement, tome 63, Janvier-Juin 1912. pp. 97-125
The Emerging Interests of Consumers: Answers from the Agri-Food Regulation
No full textThis chapter introduces the part dedicated to answers from agri-food regulation to emerging interests of consumers.
The essays contained in this part are focused on the relationship between tradition and innovation in food production and highlight the controversial coexistence of these two (apparently) opposed faces of the food chain.
The author of this introduction underlines that the “image” of the consumer is a guiding thread (or a common element) to different aspects of this issue, considering that the consumer is the final target of information and safety rules.
In fact, the lack of a clear definition of the characteristics of consumer as contracting party in transnational commercial relationships and the high level of abstraction on this subject in EU law determines juridical uncertainty, taking into account the increase in business of consumer international trade.
The author concludes his essay by recommending a solution at the international level, which needs to be more consistent with the effective dynamics of consumption
Optimally bounding a generalized gross error sensitivity of unbounded influence M-estimates of regression
No full textVito Evola et les métaphores conceptuelles dans les textes religieux
No full textCette étude analyse l’article scientifique «Semiótica Multimodal de las Experiencias Espirituales: La Representación de Creencias, Metáforas y Acciones» paru en 2009 dans l’anthologie «La Lingüística de hoy: Un paso hacia el entendimiento de la Mente» de Carmen M. Bretones et alii. L’article, écrit par le linguiste et sémiologue Vito Evola, souligne l’importance d’une approche de linguistique cognitive pour l’étude des textes religieux. Ces pages sont remarquables pour deux raisons: elles montrent quelles sont les principales métaphores conceptuelles qu’on utilise pour se rapprocher à la foi et comparent l’analyse des éléments différents, comme mots, dessins et gestes, pour comprendre la conceptualisation religieuse de l’être humain à l’égard de l’être transcendantal. Dans cette recherche, Evola se propose de souligner l’importance de la métaphore conceptuelle «Abstrait est Concret» qui peut être assimilée aux métaphores ontologiques (Lakoff et Johnson 1998: 45), lesquelles considèrent les activités, les événements, les états, les idées et les émotions comme objets et substances
Chapitre VIII. Le règne de Vito Lavelua (1895-1904)
No full textLe règne de Vito Lavelua semble avoir été assez paisible. Durant ces neuf ans, cinq résidents se succédèrent à Wallis : M. de Kéroman jusque vers la fin de 1895 ; M. Lefebvre de Sainte-Marie, nommé le 16 février 1896 ; M. Proche, arrivé à Wallis vers la fin de 1897, M. Ponge, nommé le 27 mai 1898 ; enfin M. Chaffaud, arrivé le 20 novembre 1902 et parti en avril 1904. Le Journal de la Société des Océanistes signale le passage à Wallis de l’Amiral Par- seval en octobre 1896. Ce navire amena à W..
Assessment of post-competition peak blood lactate in male and female master swimmers aged 40–79 years and its relationship with swimming performance
No full textThe main purpose of this study was to measure the postcompetition blood lactate concentration ([La]b) in master swimmers of both sexes aged between 40 and 79 years in order to relate it to age and swimming performance. One hundred and eight swimmers participating in the World Master Championships were assessed for [La]b and the average rate of lactate accumulation (La’;mmol l-1 s-1) was calculated. In addition, 77 of them were also tested for anthropometric measures. When the subjects were divided into 10-year age groups, males exhibited higher [La]b than women (factorial ANOVA, P < 0.01) and a steeper decline with ageing than female subjects. Overall, mean values (SD) of [La]b were 10.8 (2.8), 10.3 (2.0), 10.3 (1.9), 8.9 (3.2) mmol l-1 in women, and 14.2 (2.5), 12.4 (2.5), 11.0 (1.6), 8.2 (2.0) mmol l-1 in men for, respectively, 40–49, 50–59, 60–69, 70–79 years’ age groups. When, however, [La]b values were normalised for a ‘‘speed index’’, which takes into account swimming speed as a percentage of world record, these sex-related differences, although still present, were considerably attenuated. Furthermore, the differences in La’ between males and females were larger in the 40–49 age group (0.34 vs 0.20 mmol l-1 s-1 for 50-m distance) than in the 70–79 age group (0.12 vs 0.14 mmol l-1 s-1 for 50-m distance). Different physiological factors, supported by the considered anthropometric measurements, are suggested to explain the results
Chapitre VIII. Le règne de Vito Lavelua (1895-1904)
No full textLe règne de Vito Lavelua semble avoir été assez paisible. Durant ces neuf ans, cinq résidents se succédèrent à Wallis : M. de Kéroman jusque vers la fin de 1895 ; M. Lefebvre de Sainte-Marie, nommé le 16 février 1896 ; M. Proche, arrivé à Wallis vers la fin de 1897, M. Ponge, nommé le 27 mai 1898 ; enfin M. Chaffaud, arrivé le 20 novembre 1902 et parti en avril 1904. Le Journal de la Société des Océanistes signale le passage à Wallis de l’Amiral Par- seval en octobre 1896. Ce navire amena à W..
Flupirtine: intravenous and oral pharmacokinetics in the donkey
No full textINTRODUCTION
Flupirtine (FLU) is a non-opioid analgesic drug with no antipyretic
or antiphlogistic effects labelled for humans. It does not
induce the side effects associated with the classical drugs used
as pain relievers (NSAIDs and opioids). The aim of this study
was to evaluate the pharmacokinetic profiles of FLU after IV
and PO administration in healthy donkeys.
MATERIALS AND METHODS
Six Amiata breed adult jennies were randomly assigned to two
treatment groups using an open, 2 9 2 Latin-square crossover
study design. Group 1 (n = 3) received a single dose of
1 mg kg
1 of FLU injected IV (Katadolon 100 mg 3 ml
1
vial, FLU D-gluconate) into the jugular vein. Group 2 (n = 3)
received FLU (5 mg kg
1) via nasogastric tube (Efiret 100 mg
hard capsules, FLU maleate). The wash out period was 1-week.
Blood samples (5 ml) were collected at 0.083, 0.25, 0.5, 0.75,
1, 1.5, 2, 4, 6, 8, 10, 24, 36 and 48 h and plasma was then
analysed by a validated HPLC method. Drug plasma concentration
versus time curves were modeled for each subject using a
two-compartment open modeL RESULTS AND CONCLUSIONS
No behavioral changes or alterations in health parameters were
observed in the IV and PO groups of animals during or after (up
to 7 days) the drug administration. Physiological signs and
parameters were normal. After IV and PO administrations, FLU
was detectable in plasma for up to 24 h. The mean elimination
half-life was longer after PO (10.81 h) than after IV (0.90 h)
administration. The Tmax found in this study (0.33 h) was
shorter than the Tmax reported for dogs (1.42 h) (1), humans
(range 1.6–1.8 h) (2), and cats (2.78 h) (3) showing a faster
rate of absorption of the drug in donkeys. A number of factors
may be responsible for this difference: the large variation in this
parameter in the donkey, different absorption, gastric emptying,
transit time or other species-specific factors. The clearance was
4812.8 ml h kg
1 and the AUC was small, findings consistent
with a low oral bioavailability of about 20%. The pharmacokinetic
trend of FLU in donkeys was different from those earlier
reported in cats and dogs where the oral bioavailability was
40%. Surprisingly, the oral bioavailability of FLU in donkeys was
much smaller than that reported in horses (70%) (M. Giorgi personal
communication). This might be triggered by the faster
clearance value in donkeys compared to horses (411 ml h kg
1)
rather than a poor drug absorption (Cmax 937 versus
1639 ng ml
1). Further studies are needed to understand if this
active ingredient may be used in donkeys.
REFERENCES
1. Kumar R, Keshri UP, Sharma J. Flupirtine: A mini review
(2013) J Drug Deliv Therap;3:113–6.
2. De Vito V, Łebkowska-Wieruszewska B, Shaban A, Lisowski
A, Kowaski CJ, Giorgi M (2014) Pharmacokinetic profiles of
the analgesic flupirtine in dogs after the administration of
four pharmaceutical formulations. Vet Anaest Analg.
doi:10.1111/vaa.12235, in press
3. De Vito V, Łebkowska-Wieruszewska B, Owen H. Kowaski,
CJ, Giorgi M (2014) Pharmacokinetic profiles of the analgesic
drug flupirtine in cats. Vet J; 202:309–13
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