1,721,184 research outputs found
A Highly Vascularized Supraglottic Neoplasm
No full textA man in his 50s presented with intermittent dysphagia to solid foods, dry cough, foreign-body sensation in the throat, and dyspnea on effort for 4 months. His medical history included hypertension and chronic rhinosinusitis
Caution regarding assessment of toxic effects and survival in treatment de-escalation with radiotherapy vs transoral surgery for human papillomavirus-associated oropharyngeal cancer
No full textThe declared aim of the ORATOR2 randomized clinical trial1 recently reported by Palma et al in JAMA Oncology was to compare outcomes in patients with human papillomavirus–associated oropharyngeal cancer treated with primary radiotherapy (RT) vs primary transoral surgical (TOS) approach and to provide a high level of evidence to guide the selection of treatment options for a subsequent phase 3 trial. To have a direct comparison, a trial (eg, EORTC 1420) should aim to compare 2 samples receiving a single-treatment modality with a limited proportion of patients requiring adjuvant treatment for the lymph node status (multiple lymph nodes or greater than 3 cm) and/or adverse features, such as positive margins and extranodal extension discovered on the surgical specimen
How to increase the SARS-CoV-2 detection rate through the nasopharyngeal swab?
Full text linkThe 2019 novel coronavirus disease (SARS-CoV-2) is an evolving
pandemic. Since its first appearance in Wuhan, China, in December
2019, an increasing number of cases are being diagnosed worldwide.
The laboratory tests currently employed for the identification of SARSCoV-2 usually detect the viral RNA through nucleic acid amplification,
generally using the polymerase chain reaction (PCR), and the nasopharyngeal swab is the most commonly used method to obtain respiratory samples.
In conclusion, further studies are recommended in order to improve the SARS-CoV-2 detection rate through the nasopharyngeal swab.
Important implications are particularly evident in the expectation of activities re-opening, particularly for the health-care setting where the suspension of the elective activity could not be further delayed
Reply to comment on "polyarteritis nodosa: a contemporary overview"
No full textThe polyarteritis nodosa (PAN) is a systemic vasculitis involving potentially every organ and the disease spectrumranges fromsingle organ
to polyvisceral failure; we wanted to focus attention on the disease as a whole without focusing extensively on aspects of single organs.
Regarding the familial Mediterranean fever (FMF): patients with FMF are known to have a higher prevalence of vasculitis compared to
the overall population, but only 1% of the patients with FMF may have PAN. Hearing loss (HL) is a rare clinical manifestation, but it has emerged in the recent scientific literature and mentioned in many papers describing histo-pathological aspects of the internal ear, so that they have contributed to the understanding of the pathogenesis of PAN
[Paucisymptomatic pneumonia due to Rothia mucilaginosa: case report and literature review].
Full text linkRothia mucilaginosa is a Gram-positive, coagulase-negative, encapsulated, non-spore-forming coccus considered part of the commensal flora of the oral cavity and the upper respiratory tract in humans. Its involvement has been reported in an increasing spectrum of infections, above all among immunocompromised patients. To date, only 11 cases of pneumonia due to Rothia mucilaginosa have been described in the literature. The authors report a case of pneumonia due to Rothia mucilaginosa in a 72-year-old man with laryngeal cancer and review the published cases of pneumonia due to this pathogen
The role of cricohyoidoepiglottopexy in the era of transoral laser surgery and radio/chemotherapy.
No full textN/
A submucosal retropharyngeal pulsatile mass
No full textA woman in her 70s was referred to our hospital for evaluation of a dry cough, foreign body sensation in the throat, and mild dysphagia of 2 months’ duration. She had no dyspnea or hoarseness
Long-lasting clinical, radiological and immunological remission of severe nasal polyposis by means of 'reboot' surgery
Full text linkA 68-year-old woman with a long history of relapsing chronic rhinosinusitis with nasal polyps (CRSwNP) underwent a complete reboot surgery and nasal biopsy prior to and after surgery. Remarkable improvement of symptoms and no signs of mucosal oedema and no complaints of initially worsening nasal functions were still present 12 months after reboot surgery. Biopsy demonstrated an outstanding reduction in eosinophilic infiltration and re-epithelisation of nasal mucosa with normal features after reboot approach compared with previous surgeries. Therefore, reboot approach may become an effective instrument in plurioperated patients with CRSwNP who suffer from a nasal condition that is recalcitrant to pharmacological therapies and is unsatisfactorily treated by standard surgical techniques
Evidence-based review of treatment options for patients with glottic cancer
No full textEvidence-based review of treatment options for patients with glottic cance
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